Integration of HBV-DNA may not be a prerequisite for the maintenance of the state of malignant transformation

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

Enhanced autoradiographic detection of ³²P and ¹²⁵I using intensifying screens and hypersensitized film

1977 • 947 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

1981 • 351 citations

DETECTION OF HEPATITIS B VIRUS DNA IN LIVER AND SERUM: A DIRECT APPRAISAL OF THE CHRONIC CARRIER STATE

1981 • 333 citations

Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen

1979 • 298 citations

Viral Hepatitis. 1981 International Symposium.

1983 • 264 citations

Evidence That Hepatitis B Virus Has a Role in Liver-Cell Carcinoma in Alcoholic Liver Disease

1982 • 253 citations

Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322

1979 • 239 citations

Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas

1981 • 217 citations

Detection of Hepatitis B Virus DNA in Pancreas, Kidney and Skin of Two Human Carriers of the Virus

1984 • 186 citations

The detection of hbv‐dna in serum by molecular hybridisation: A more sensitive method for the detection of complete hbv particles

1982 • 178 citations

Hepatitis B viral DNA in liver and serum of asymptomatic carriers.

1982 • 148 citations

Viral nucleic acid synthesis and antigen accumulation in pancreas and kidney of Pekin ducks infected with duck hepatitis B virus.

1983 • 120 citations

Cloning and endonuclease mapping of the hepatitis B viral genome

1979 • 120 citations

Detection of serum HBV-DNA by molecular hybridisation

1985 • 110 citations

Detection of Hepatitis B Virus DNA in Hepatocellular Carcinomas in Japan

1984 • 102 citations

Isolation, characterization, and comparison of recombinant DNAs derived from genomes of human hepatitis B virus and woodchuck hepatitis virus.

1980 • 94 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from a chronically infected liver

1984 • 61 citations

The mechanism of replication of hepatitis B virus: Evidence of asymmetric replication of the two DNA strands

1984 • 47 citations

Patterns of Single- and Double-stranded Hepatitis B Virus DNA and Viral Antigen Accumulation in Infected Liver Cells

1983 • 45 citations

A rapid one-step radiometric assay for hepatitis B surface antigen utilising monoclonal antibodies

1982 • 45 citations

Analysis of hepatitis virus dna in the liver and serum of hbe antigen positive chimpanzee carriers

1982 • 39 citations

Analysis of the molecular state of HBV-DNA in the liver and serum of patients with chronic hepatitis or primary liver cell carcinoma and the effect of therapy with adenine arabinoside.

1984 • 32 citations

Hepatitis B Virus Infection: The Impact of Molecular Biology

1983 • 32 citations

The Molecular Biology of Hepatitis B Virus

1984 • 21 citations

Integration of HBV‐DNA into liver and hepatocellular carcinoma cells during persistent HBV infection

1982 • 19 citations

Defective Hepatitis B Virus DNA Molecules Detected in a Stable Integration Pattern in a Hepatoma Cell Line, and in Induced Tumours and Derived Cell Lines

1983 • 12 citations

Hepatitis B viral DNA in liver and serum of asymptomatic carriers

1983 • 9 citations