The efficacy of N-acetylcysteine in preventing doxorubicin-induced cardiomyopathy in dogs.

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Reduction of Doxorubicin Cardiotoxicity by Prolonged Continuous Intravenous Infusion

1982 • 768 citations

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

1980 • 711 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Cardiac disease induced by chronic adriamycin administration in dogs and an evaluation of vitamin E and selenium as cardioprotectants.

1980 • 169 citations

Adriamycin given as a weekly schedule without a loading course: clinically effective with reduced incidence of cardiotoxicity.

1980 • 119 citations

Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187).

1981 • 107 citations

Failure of the antioxidant vitamin E to protect against adriamycin-induced cardiotoxicity in the rabbit.

1980 • 97 citations

Prevention of the Cardiotoxic Effects of Adriamycin and Daunomycin in the Isolated Dog Heart

1972 • 61 citations

Cardiotoxicity and comparative pharmacokinetics of six anthracyclines in the rabbit.

1980 • 59 citations

Pathophysiology of acetaminophen overdosage toxicity: implications for management.

1978 • 56 citations

Rescue by coenzyme Q10 from electrocardiographic abnormalities caused by the toxicity of adriamycin in the rat.

1978 • 43 citations

Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.

1977 • 38 citations

Daunorubicin-stimulated reactive oxygen metabolism in cardiac sarcosomes

1981 • 38 citations

Effect of sulfhydryl-containing compounds on the antitumor effects of adriamycin

1980 • 36 citations

A totally noninvasive method for obtaining systolic time intervals in the dog.

1978 • 31 citations

Modification by adenosine of the effect of adriamycin on myocardial cells in culture.

1979 • 27 citations

Toxicity of acetaminophen overdose

1978 • 22 citations

CARNITINE PREVENTION OF ADRIAMYCIN TOXICITY IN MICE

1978 • 19 citations

Reduction by coenzyme Q10 of the acute toxicity of adriamycin in mice.

1977 • 18 citations

Synthesis and antitumor activity of 4-demethoxyadriamycin and 4-demethoxy-4' -epiadriamycin.

1978 • 14 citations

Blockade of tissue uptake of the antineoplastic agent, doxorubicin.

1978 • 13 citations

Pharmacokinetic, toxicologic, and chemotherapeutic properties of detorubicin in mice: a comparative study with daunorubicin and adriamycin.

1979 • 11 citations

Inhibition of adriamycin cardiotoxicity by acetyldaunomycin

1975 • 7 citations