Rimantadine Hydrochloride and Amantadine Hydrochloride Use in Influenza A Virus Infections

Antiviral Activity of 1-Adamantanamine (Amantadine)

1964 • 805 citations

The molecular basis of the specific anti-influenza action of amantadine.

1985 • 800 citations

Amantadine in the Treatment of Parkinson's Disease

1969 • 599 citations

A Controlled Trial of Amantadine and Rimantadine in the Prophylaxis of Influenza a Infection

1982 • 501 citations

Plaque inhibition assay for drug susceptibility testing of influenza viruses

1980 • 280 citations

Therapeutic Efficacy of Amantadine HCl and Rimantadine HCl in Naturally Occurring Influenza A2 Respiratory Illness in Man

1969 • 230 citations

Airway hyperreactivity and peripheral airway dysfunction in influenza A infection.

1978 • 184 citations

The toxicologic and pharmacologic properties of amantadine hydrochloride

1969 • 181 citations

Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride

1969 • 177 citations

Influenza: Its Control in Persons and Populations

1986 • 177 citations

Successful treatment of naturally occurring influenza A/USSR/77 H1N1

1981 • 169 citations

Amantadine-Dopamine Interaction: Possible Mode of Action in Parkinsonism

1970 • 168 citations

Absorption, distribution and excretion of amantadine hydrochloride.

1965 • 164 citations

On the Mechanism of Inhibition of Influenza Virus Replication by Amantadine Hydrochloride

1978 • 145 citations

Dopamine: Release from the Brain in vivo by Amantadine

1971 • 140 citations

Amantadine in Parkinson's Disease

1972 • 133 citations

Prevention of Russian Influenza by Amantadine

1979 • 122 citations

Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults

1981 • 118 citations

Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics

1983 • 113 citations

PROTECTIVE EFFECT OF 1-ADAMANTANAMINE HYDROCHLORIDE ON INFLUENZA A2 INFECTIONS IN THE FAMILY ENVIRONMENT

1969 • 109 citations

Pharmacokinetics of Amantadine Hydrochloride in Subjects with Normal and Impaired Renal Function

1981 • 109 citations

Influenza Virus Uncoating in Infected Cells and Effect of Rimantadine

1982 • 106 citations

Successful Treatment of Naturally Occurring Influenza A/USSR/77 H1N1

1981 • 105 citations

Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein

1978 • 105 citations

Reduction in fever and symptoms in young adults with influenza A/Brazil/78 H1N1 infection after treatment with aspirin or amantadine

1983 • 103 citations

Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults

1985 • 103 citations

Impact of Influenza A in a Nursing Home

1982 • 102 citations

Antiviral activity of amantadine: a review of laboratory and clinical data

1980 • 99 citations

PREVENTION OF NOSOCOMIAL INFLUENZA INFECTION WITH AMANTADINE1

1973 • 96 citations

Visual Hallucinations and Delirium During Treatment with Amantadine (Symmetrel)

1975 • 95 citations

Torsade de pointe

1984 • 87 citations

Antiviral chemotherapy: New directions for clinical application and research

1989 • 83 citations

A Nosocomial Outbreak of Influenza A

1977 • 81 citations

Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults

1986 • 80 citations

Amantadine Prophylaxis During an Institutional Outbreak of Type A (H1N1) Influenza

1986 • 76 citations

A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis

1980 • 75 citations

Amantadine Effect on Peripheral Airways Abnormalities in Influenza

1976 • 75 citations

AMANTADINE DOSAGE IN TREATMENT OF PARKINSON'S DISEASE

1970 • 74 citations

Effectiveness of Rimantadine Prophylaxis of Children Within Families

1986 • 71 citations

Study of 1-adamantanamine hydrochloride used prophylactically during the Hong Kong influenza epidemic in the family environment.

1969 • 67 citations

Study of Rimantadine in the USSR: A Review of the Literature

1981 • 66 citations

Inhibition of influenza virus uncoating by rimantadine hydrochloride

1979 • 65 citations

Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus

1985 • 64 citations

Amantadine kinetics in healthy young subjects after long‐term dosing

1979 • 56 citations

INFLUENZA A PROPHYLAXIS WITH AMANTADINE IN A BOARDING SCHOOL

1984 • 56 citations

Amantadine-resistant and -sensitive Influenza A Strains and Recombinants

1979 • 55 citations

TOXIC EFFECTS OF AMANTADINE IN PATIENTS WITH RENAL FAILURE

1979 • 55 citations

Evaluation of Amantadine in the Prophylaxis of Influenza A (H1N1) Virus Infection: A Controlled Field Trial among Young Adults and High-Risk Patients

1980 • 52 citations

Therapeutic Effects of Aerosolized Amantadine in Naturally Acquired Infection Due to Influenza A Virus

1980 • 51 citations

Occurrence of amantadine- and rimantadine-resistant influenza A virus strains during the 1980 epidemic.

1981 • 51 citations

Amantadine kinetics in healthy elderly men: Implications for influenza prevention

1985 • 50 citations

The suppression of A2 influenza in children by the chemoprophylactic use of Amantadine

1966 • 47 citations

Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis

1976 • 46 citations

Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes

1984 • 45 citations

The intracellular distribution and antiviral activity of amantadine

1981 • 44 citations

Small-Particle Aerosols of Antiviral Compounds in Treatment of Type A Influenza Pneumonia in Mice

1976 • 44 citations

Antiviral Agents in Influenza--Summary of Influenza Workshop VIII

1976 • 43 citations

Amantadine Hydrochloride Pharmacokinetics in Hemodialysis Patients

1980 • 43 citations

Combinations of antiviral agents for treatment of influenza virus infections

1986 • 41 citations

Acute Toxic Psychosis From Suicidal Overdosage of Amantadine

1971 • 39 citations

Amantadine-dyazide interaction.

1983 • 39 citations

Synergistic Effect of Combinations of Sulfamethoxazole, Trimethoprim, and Colistin Against Pseudomonas maltophilia and Pseudomonas cepacia

1974 • 39 citations

Effect of 1-Amantanamine Hydrochloride (Amantadine HCl) and Methyl-1-Adamatanethylamine Hydrochloride (Rimantadine HCl) on Transmission of Influenza Virus Infection in Mice

1968 • 37 citations

A revision of the metabolic disposition of amantadine

1985 • 36 citations

Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine

1982 • 36 citations

Amantadine in the treatment of refractory epilepsy in childhood

1985 • 36 citations

Coloured Lilliputian Hallucinations with Amantadine

1973 • 34 citations

Pharmacokinetics and Clinical Effects of Amantadine in Drug‐Induced Extrapyramidal Symptoms

1977 • 34 citations

Amantadine: Does It Have a Role in the Prevention and Treatment of Influenza? A National Institutes of Health Consensus Development Conference

1980 • 33 citations

Administration of amantadine for the prevention of Hong Kong influenza.

1970 • 27 citations

Amantadine aerosol in humans

1979 • 27 citations

Fate of influenza a virion proteins after entry into subcellular fractions of LLC cells and the effect of amantadine

1986 • 27 citations

Use and withdrawal of amantadine chemoprophylaxis during epidemic influenza A.

1976 • 26 citations

FIELD STUDIES WITH AMANTADINE: ACCEPTABILITY AND PROTECTION

1970 • 23 citations

Vision loss associated with amantadine hydrochloride use

1977 • 22 citations

Anti-influenza A virus activity of amantadine hydrochloride and rimantadine hydrochloride in ferret tracheal ciliated epithelium

1982 • 21 citations

Rimantadine pharmacokinetics after single and multiple doses

1987 • 21 citations

Effect of Amantadine Hydrochloride on the Response of Human Lymphocytes to Phytohemagglutinin

1967 • 20 citations

The effects of peroral or local aerosol administration of 1-aminoadamantane hydrochloride (amantadine hydrochloride) on influenza infections of the ferret

1977 • 20 citations

Aminoadamantane-resistant strains of influenza A2 virus

1973 • 19 citations

Comparative activity of amantadine and ribavirin against influenza virus in vitro: possible clinical relevance

1983 • 17 citations

Influenza 1959

1959 • 16 citations

Treatment of acute amantadine toxicity with physostigmine

1979 • 15 citations

In Vitro Binding of Amantadine to Plasma Proteins

1984 • 15 citations

THE IMMUNOSUPPRESSIVE EFFECT OF AMANTADINE UPON THE RESPONSE OF LYMPHOCYTES TO SPECIFIC ANTIGENS IN VITRO

1971 • 15 citations

Effect of amantadine hydrochloride on parainfluenza type 1 virus infections in adult volunteers.

1967 • 12 citations

Influenza virus strains with a fusion threshold of pH5.5 or lower are inhibited by amantadine

1986 • 11 citations

Amantadine for Severe Influenza A Pneumonia in Infancy

1980 • 11 citations

Influenza in a geriatric unit

1979 • 10 citations

Use of amantadine in influenza: a second report.

1983 • 10 citations

Binding of Amantadine to Red Blood Cells

1984 • 3 citations