Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

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The importance of dose intensity in chemotherapy of metastatic breast cancer.

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Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

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Construction and use of a safe and efficient amphotropic packaging cell line

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Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial.

1995 • 415 citations

Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL- 6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts

1996 • 326 citations

A Mus dunni cell line that lacks sequences closely related to endogenous murine leukemia viruses and can be infected by ectropic, amphotropic, xenotropic, and mink cell focus-forming viruses

1984 • 232 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

Bone marrow autotransplantation for solid tumors--prospects.

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Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy

1996 • 160 citations

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Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer

1992 • 144 citations

Transfer and expression of the human multiple drug resistance gene in human CD34+ cells

1994 • 137 citations

High-dose chemotherapy followed by autologous bone marrow transplantation versus dexamethasone, cisplatin, and cytarabine in aggressive non-Hodgkin's lymphoma with partial response to front-line chemotherapy: a prospective randomized italian multicenter study.

1996 • 137 citations

Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro

1996 • 110 citations

Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model.

1994 • 91 citations

RAPID ISOLATION OF HUMAN CD34 HEMATOPOIETIC STEM CELLS—PURGING OF HUMAN TUMOR CELLS

1992 • 90 citations

Preselection of transduced murine hematopoietic stem cell populations leads to increased long-term stability and expression of the human multiple drug resistance gene

1995 • 59 citations

Human MDR Gene Transfer in Patients with Advanced Cancer. Columbia University, New York, New York

1994 • 53 citations

A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy

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Peripheral blood stem cell mobilization after stem cell factor or G-CSF treatment: rapid enrichment for stem and progenitor cells using the CEPRATE immunoaffinity separation system.

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1992 • 20 citations