Complement anaphylatoxin C5a neuroprotects through mitogen‐activated protein kinase‐dependent inhibition of caspase 3

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

1993 • 726 citations

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

1999 • 581 citations

BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway.

2000 • 517 citations

BDNF Protects the Neonatal Brain from Hypoxic-Ischemic InjuryIn Vivovia the ERK Pathway

2000 • 432 citations

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

1994 • 418 citations

The C5a chemoattractant receptor mediates mucosal defence to infection

1996 • 345 citations

Complement components of the innate immune system in health and disease in the CNS

2000 • 343 citations

Progesterone protects against lipid peroxidation following traumatic brain injury in rats

1997 • 315 citations

Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis.

1992 • 244 citations

Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain

1997 • 187 citations

Excitotoxic Neurodegeneration in Alzheimer Disease

1997 • 187 citations

Midkine Inhibits Caspase‐Dependent Apoptosis via the Activation of Mitogen‐Activated Protein Kinase and Phosphatidylinositol 3‐Kinase in Cultured Neurons

1999 • 184 citations

Development of C5a receptor antagonists. Differential loss of functional responses.

1994 • 152 citations

Induction of interleukin-8 synthesis from monocytes by human C5a anaphylatoxin.

1994 • 144 citations

Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis

1997 • 143 citations

Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity

1999 • 134 citations

Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Strategies

1997 • 130 citations

Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system

1996 • 111 citations

Reactions of the Immune System in Chronic Degenerative Neurological Diseases

1991 • 87 citations

Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines

1999 • 85 citations

The Complement System

1975 • 82 citations

Complement activation and β-amyloid-mediated neurotoxicity in Alzheimer's disease

1992 • 81 citations

TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis.

1997 • 79 citations

The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer’s disease

2000 • 77 citations

Agonist Stimulation of the Serotonin_1A Receptor Causes Suppression of Anoxia‐Induced Apoptosis via Mitogen‐Activated Protein Kinase in Neuronal HN2‐5 Cells

1999 • 76 citations

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration

1999 • 74 citations

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

1995 • 63 citations

Association of amyloid P component with complement proteins in neurologically diseased brain tissue

1991 • 59 citations

Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas

1998 • 45 citations

Focal Inflammation in the Brain: Role in Alzheimer's Disease

2000 • 41 citations

PACAP‐38 Protects Cerebellar Granule Cells from Apoptosis

1998 • 37 citations

The Complement System

1988 • 33 citations

Complement and glutamate neurotoxicity

1997 • 27 citations

Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines

1999 • 21 citations