Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi

Isolation and cultivation of Lyme disease spirochetes.

1984 • 1,554 citations

Induction of an outer surface protein on Borrelia burgdorferi during tick feeding.

1995 • 825 citations

Western Blotting in the Serodiagnosis of Lyme Disease

1993 • 693 citations

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

1990 • 480 citations

Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody

1983 • 443 citations

Chronic Lyme borreliosis in the laboratory mouse.

1993 • 319 citations

Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi

1993 • 294 citations

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

1990 • 269 citations

Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

1992 • 243 citations

Experimental Lyme Disease in Dogs Produces Arthritis and Persistent Infection

1993 • 224 citations

Isolation of Antigenic Components from the Lyme Disease Spirochete: Their Role in Early Diagnosis

1987 • 203 citations

Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties

1993 • 191 citations

Recombinant Outer Surface Protein A from Borrelia burgdorferi Induces Antibodies Protective against Spirochetal Infection in Mice

1991 • 185 citations

Borrelia burgdorferi genes selectively expressed in the infected host.

1995 • 175 citations

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice

1992 • 173 citations

Lyme Borreliosis in Genetically Resistant and Susceptible Mice with Severe Combined Immunodeficiency

1992 • 170 citations

Western blot analysis of sera from Lyme borreliosis patients according to the genomic species of theBorrelia strains used as antigens

1993 • 164 citations

Serodiagnosis of Lyme borreliosis by western immunoblot: reactivity of various significant antibodies against Borrelia burgdorferi

1992 • 157 citations

Carditis in Lyme Disease Susceptible and Resistant Strains of Laboratory Mice Infected with Borrelia Burgdorferi

1992 • 153 citations

Serodiagnosis in early Lyme disease

1993 • 144 citations

Linear- and circular-plasmid copy numbers in Borrelia burgdorferi

1992 • 135 citations

Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans

1993 • 132 citations

Immune capture and detection of Borrelia burgdorferi antigens in urine, blood, or tissues from infected ticks, mice, dogs, and humans

1991 • 130 citations

Passive immunizing activity of sera from mice infected with Borrelia burgdorferi

1993 • 120 citations

Target Imbalance: Disparity of Borrelia burgdorferi Genetic Material in Synovial Fluid from Lyme Arthritis Patients

1994 • 119 citations

A 9.0-kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection

1994 • 114 citations

Mode of Inoculation of the Lyme Disease Agent Borrelia burgdorferi Influences Infection and Immune Responses in Inbred Strains of Mice

1993 • 106 citations

Validity of western immunoblot band patterns in the serodiagnosis of Lyme borreliosis

1991 • 104 citations

Outer surface protein a (OspA) from the lyme disease spirochete, borrelia burgdorferi: High level expression and purification of a soluble recombinant form of OspA

1990 • 103 citations

Fate Of Borrelia burgdorferi DNA In Tissues Of Infected Mice After Antibiotic Treatment

1994 • 91 citations

Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine.

1994 • 90 citations

The hamster immune response to tick-transmitted Borrelia burgdorferi differs from the response to needle-inoculated, cultured organisms.

1992 • 82 citations

Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi

1993 • 81 citations

Structural features of Borrelia burgdorferi--the Lyme disease spirochete: silver staining for nucleic acids.

1989 • 69 citations

Demonstration of a B-lymphocyte mitogen produced by the Lyme disease pathogen, Borrelia burgdorferi

1992 • 67 citations

Early and specific antibody response to OspA in Lyme Disease.

1994 • 64 citations

Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen

1993 • 58 citations

Immune sera to individual Borrelia burgdorferi isolates or recombinant OspA thereof protect SCID mice against infection with homologous strains but only partially or not at all against those of different OspA/OspB genotype

1993 • 57 citations

Nucleotide sequence and analysis of the gene inBorrelia burgdorferiencoding the immunogenic P39 antigen

1994 • 53 citations

Antigenic stability of Borrelia burgdorferi during chronic infections of immunocompetent mice

1993 • 52 citations

Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens

1992 • 49 citations

Expression and gene sequence of outer surface protein C of Borrelia burgdorferi reisolated from chronically infected mice

1994 • 48 citations

Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines.

1993 • 43 citations

Immunization of mice by recombinant OspA preparations and protection against Borrelia burgdorferi infection induced by Ixodes ricinus tick bites

1994 • 41 citations

OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection

1993 • 39 citations

Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection

1995 • 35 citations

Tick transmission of Borrelia burgdorferi to inbred strains of mice induces an antibody response to P39 but not to outer surface protein A

1994 • 34 citations

The major histocompatibility complex-restricted response of recombinant inbred strains of mice to natural tick transmission of Borrelia burgdorferi.

1993 • 31 citations

Efficacy of Human Lyme Disease Vaccine Formulations in a Mouse Model

1995 • 31 citations

Interactions between extracellular Borrelia burgdorferi proteins and non-Borrelia-directed immunoglobulin M antibodies

1992 • 28 citations

Extrachromosomal elements of spirochetes

1992 • 27 citations

Factors influencing the antigenic reactivity of Borrelia burgdorferi, the Lyme disease spirochete.

1991 • 25 citations

An OspA antigen-capture enzyme-linked immunosorbent assay for detecting North American isolates of Borrelia burgdorferi in larval and nymphal Ixodes dammini

1993 • 19 citations