In Vitro Studies on Thyroid Hormone Receptors

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Female Steroid Hormones and Target Cell Nuclei

1974 • 946 citations

Regulation of Enzyme Activity

1966 • 612 citations

Free thyroxine in human serum: simplified measurement with the aid of magnesium precipitation.

1966 • 415 citations

Relation of steroid structure to enzyme induction in hepatoma tissue culture cells

1970 • 399 citations

The Mechanism of the Calorigenic Action of Thyroid Hormone

1971 • 372 citations

Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.

1976 • 364 citations

PRODUCTION OF BOTH PROLACTIN AND GROWTH HORMONE BY CLONAL STRAINS OF RAT PITUITARY TUMOR CELLS

1970 • 342 citations

Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones.

1977 • 342 citations

Thyroid Hormone Action in Cell Culture: Demonstration of Nuclear Receptors in Intact Cells and Isolated Nuclei

1973 • 337 citations

Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture

1975 • 300 citations

Human Growth Hormone Radioreceptor Assay using Cultured Human Lymphocytes

1973 • 286 citations

Early Events in Glucocorticoid Action

1973 • 257 citations

Mechanism of Thyroid Calorigenesis: Role of Active Sodium Transport

1970 • 242 citations

Thyroid Hormone Action IN VITRO CHARACTERIZATION OF SOLUBILIZED NUCLEAR RECEPTORS FROM RAT LIVER AND CULTURED GH1 CELLS

1974 • 229 citations

Estrogen Action in Vitro

1972 • 221 citations

Triiodothyronine Binding to Isolated Liver Cell Nuclei

1975 • 207 citations

Effect of thyroid hormones on the level of the hepatic mRNA for α_2u globulin

1976 • 201 citations

Limited Capacity Binding Sites for l-Triiodothyronine in Rat Liver Nuclei

1973 • 185 citations

Thyroid Hormone Action: A Cell-Culture System Responsive to Physiological Concentrations of Thyroid Hormones

1973 • 184 citations

Effect of triiodothyronine on the synthesis and degradation of renal cortical (Na+ + k+)-adenosine triphosphatase

1976 • 184 citations

Thyroid hormone receptors. Binding characteristics and lack of hormonal dependency for nuclear localization

1975 • 182 citations

Partial Purification of the Template-Active Fraction of Chromatin: A Preliminary Report

1974 • 175 citations

Regulation of growth hormone gene expression: synergistic effects of thyroid and glucocorticoid hormones.

1977 • 174 citations

Thyroid and glucocorticoid hormones synergistically control growth hormone mRNA in cultured GH1 cells.

1978 • 169 citations

Binding of selected iodothyronine analogues to receptor sites of isolated rat hepatic nuclei. High correlation between structural requirements for nuclear binding and biological activity

1975 • 167 citations

Thyroid thermogenesis. Relationships between Na+-dependent respiration and Na+ + K+-adenosine triphosphatase activity in rat skeletal muscle.

1976 • 161 citations

Limited Binding Capacity Sites for l-Triiodothyronine in Rat Liver Nuclei

1974 • 160 citations

Thyroid Hormone Inhibition of the Prolactin Response to Thyrotropin-Releasing Hormone

1973 • 155 citations

Triiodothyronine stimulates specifically growth hormone mRNA in rat pituitary tumor cells.

1977 • 154 citations

Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process.

1976 • 148 citations

Dose-dependent depletion of nuclear receptors by L-triiodothyronine: evidence for a role in induction of growth hormone synthesis in cultured GH1 cells.

1976 • 139 citations

Isolation, purification, and fractionation of nonhistone chromosomal proteins

1973 • 134 citations

Thyroid hormone action. Demonstration of similar receptors in isolated nuclei of rat liver and cultured GH1 cells.

1974 • 129 citations

Modulation of thyroid hormone nuclear receptor levels by 3,5,3'-triiodo-L-thyronine in GH1 cells. Evidence for two functional components of nuclear-bound receptor and relationship to the induction of growth hormone synthesis.

1977 • 124 citations

Thyroid hormone binding by a component of mitochondrial membrane.

1975 • 122 citations

Triiodothyronine Binding to Liver Nuclear Solubilized Proteins in Vitro

1975 • 115 citations

In vitro binding of L-triiodothyronine to receptors in rat liver nuclei. Kinectics of binding, extraction properties, and lack of requirement for cytosol proteins.

1975 • 115 citations

Quantitative Aspects of Iodothyronine Binding by Cytosol Proteins of Rat Liver and Kidney

1974 • 109 citations

Thyroid hormone action: Stimulation of growth hormone and inhibition of prolactin secretion in cultured GH1 cells

1974 • 106 citations

Determination of Free Thyroxine in Human Serum: A Theoretical and Experimental Analysis

1964 • 98 citations

How specific are nuclear “receptors” for thyroid hormones?

1975 • 96 citations

Binding of T₃in Rat Liver Nuclei

1974 • 91 citations

Effects of thyroid status on electrolyte distribution in rat tissues

1973 • 89 citations

Thyroid hormone controls glucocorticoid action in cultured GH1 cells

1977 • 89 citations

Nuclear Binding Capacity Appears to Limit the Hepatic Response to L-Triiodothyronine (T₃)

1975 • 84 citations

THYROID HORMONE ACTION: DEMONSTRATION OF PUTATIVE NUCLEAR RECEPTORS IN HUMAN LYMPHOCYTES

1974 • 82 citations

Glucocorticoid induction of growth hormone synthesis in a strain of rat pituitary cells.

1977 • 78 citations

THE EFFECT OF ALTERATIONS IN THYROID FUNCTION ON THE PITUITARY GROWTH HORMONE CONTENT AND ACIDOPHIL CYTOLOGY¹

1959 • 70 citations

Stimulation of Mitochondrial Adenosine Diphosphate Uptake by Thyroid Hormones

1973 • 69 citations

Cycloleucine Transport in Isolated Rat Thymocytes:In VitroEffects of Triiodothyronine and Thyroxine

1975 • 63 citations

In vitro triiodothyronine binding to non-histone proteins from rat liver nuclei

1974 • 61 citations

Regulation of Thyrotropin Production by Mouse Pituitary Thyrotropic Tumor Cells in Vitro by Physiological Levels of Thyroid Hormones*

1978 • 52 citations

Activities of thyroid hormones and related compounds in an in vitro thymocyte assay.

1976 • 51 citations

Time-Course of the Effects of Thyroid Hormone on Respiration and Na+ + K+-ATPase Activity in Rat Liver

1974 • 51 citations

Cortisol Induction of Growth Hormone Synthesis in a Clonal Line of Rat Pituitary Tumor Cells in Culture

1969 • 51 citations

DNA binding of thyroid hormone receptors

1975 • 48 citations

Stimulation of the Uptake of α-Aminoisobutyric Acid in Rat Thymocytes by L-Triiodothyronine: A Comparison with Insulin and Dibutyryl Cyclic AMP

1975 • 48 citations

Regulation of mitochondrial protein synthesis at the polyribosomal level.

1976 • 44 citations

A role of thyroid hormones in differentiation of mouse mammary gland in vitro

1975 • 37 citations

Triiodothyronine binding proteins in rat liver cytosol

1975 • 35 citations