Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury.

ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS

1974 • 12,376 citations

The biology of interleukin-6

1989 • 1,964 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Biology of interleukin 1

1988 • 1,547 citations

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

1990 • 1,307 citations

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

1984 • 1,136 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

1985 • 1,110 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Increased plasma levels of interleukin-6 in sepsis [see comments]

1989 • 813 citations

Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

1989 • 785 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.

1990 • 548 citations

Corticotropin-Releasing Activity of Monokines

1985 • 500 citations

Peptide Regulatory Factors

1989 • 498 citations

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

1988 • 458 citations

Combined Hormonal Infusion Simulates the Metabolic Response to Injury

1984 • 448 citations

Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.

1989 • 411 citations

Mechanism of Prevention of Postburn Hypermetabolism and Catabolism by Early Enteral Feeding

1984 • 409 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Hypermetabolism, organ failure, and metabolic support.

1987 • 362 citations

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

1987 • 358 citations

The Microbiology of Multiple Organ Failure

1988 • 330 citations

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

1985 • 294 citations

Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis

1989 • 278 citations

The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion, and gut mucosal integrity after burn injury

1987 • 263 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats

1989 • 252 citations

Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.

1988 • 249 citations

The metabolic response to severe head injury

1984 • 239 citations

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells.

1987 • 228 citations

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

1989 • 227 citations

Adrenocorticotropin Release Induced by Intracerebroventricular Injection of Recombinant Human Interleukin-1 in Rats: Possible Involvement of Prostaglandin*

1988 • 221 citations

Human β ₂ Interferon and B-Cell Differentiation Factor BSF-2 Are Identical

1987 • 204 citations

Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.

1987 • 199 citations

Intestinal endotoxemia

1988 • 198 citations

Interleukin-6 is the Major Regulator of Acute Phase Protein Synthesis in Rat and Man

1989 • 182 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

The Role of Interleukin‐6 as the Hepatocyte Stimulating Factor in the Network of Inflammatory Cytokines^a

1989 • 177 citations

Antibiotic Therapy, Endotoxin Concentration in Cerebrospinal Fluid, and Brain Edema in Experimental Escherichia coli Meningitis in Rabbits

1987 • 166 citations

Ventricular fluid interleukin-1 activity in patients with head injury.

1987 • 164 citations

Increased plasma interleukin-8 concentrations in alcoholic hepatitis

1993 • 159 citations

Promotion by Burn Stress of the Translocation of Bacteria From the Gastrointestinal Tracts of Mice

1984 • 157 citations

Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.

1989 • 142 citations

Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6.

1990 • 140 citations

Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury

1989 • 139 citations

Assessment of nutritional requirements of head-injured patients

1986 • 135 citations

The Regulation of ACTH Secretion by IL-1

1987 • 132 citations

The acute-phase response of the brain-injured patient

1988 • 130 citations

Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone

1987 • 120 citations

Direct stimulation of the adrenal cortex by interleukin-1.

1987 • 117 citations

Metabolic and Nutritional Sequelae in the Non-Steroid Treated Head Injury Patient

1985 • 111 citations

Serum and urine zinc response in head-injured patients

1986 • 108 citations

Cachectin/tumor necrosis factor: An endogenous mediator of shock and inflammation

1986 • 103 citations

Production of Interleukin-6 by Anterior Pituitary Cells Is Stimulated by Increased Intracellular Adenosine 3′,5′ Monophosphate and Vasoactive Intestinal Peptide*

1990 • 95 citations

Increased Endotoxin and Interleukin-1 Concentrations in Cerebrospinal Fluid of Infants with Coliform Meningitis and Ventriculitis Associated with Intraventricular Gentamicin Therapy

1989 • 87 citations

Cerebrospinal fluid interleukin 1-beta and tumor necrosis factor concentrations and outcome from neonatal gram-negative enteric bacillary meningitis.

1989 • 86 citations

Metabolic changes in the course of severe acute Brain Damage

1975 • 76 citations

Mechanisms and implications of hypoalbuminemia in head-injured patients

1988 • 58 citations

Tumor Necrosis Factor-Mediated Hypoalbuminemia in Rabbits

1988 • 54 citations

Detection of Interleukin 1β but Not Tumor Necrosis Factor—α in Cerebrospinal Fluid of Children With Aseptic Meningitis

1990 • 52 citations

Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-1 beta

1988 • 43 citations

The inflammation mediators interleukin 1 and hepatocyte-stimulating factor are differently regulated in human monocytes

1987 • 43 citations

Monokine-induced acute lung injury in rabbits

1987 • 40 citations

Serum copper and ceruloplasmin levels and urinary copper excretion in thermal injury

1986 • 39 citations

Modulation of endothelial function by interleukin-1

1987 • 31 citations

B-cell line-derived interleukin 1 is cytotoxic for melanoma cells and promotes the proliferation of an astrocytoma cell line.

1987 • 29 citations

Metabolic Management of the Patient with Head Injury

1991 • 26 citations

Human Interferon-β2

1987 • 24 citations

Biological Activities of Recombinant Human IFN‐β2/IL‐6 (E. coli)^a

1989 • 16 citations

Orphan Interferon Finds a New Home

1988 • 10 citations

Wound inflammatory mediators and multisystem organ failure.

1987 • 5 citations

HSF Activity of a Mononuclear Cell‐derived B‐Cell Growth Factor

1989 • 1 citations