Therapy of small cell lung cancer: a perspective on two decades of clinical research.

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Dose: A critical factor in cancer chemotherapy

1980 • 851 citations

MEDICAL RESEARCH COUNCIL COMPARATIVE TRIAL OF SURGERY AND RADIOTHERAPY FOR PRIMARY TREATMENT OF SMALL-CELLED OR OAT-CELLED CARCINOMA OF BRONCHUS

1973 • 528 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Chemotherapy with or without Radiation Therapy in Limited Small-Cell Carcinoma of the Lung

1987 • 484 citations

CNS metastases in small cell bronchogenic carcinoma.Increasing frequency and changing pattern with lengthening survival

1979 • 478 citations

Keynote address on biostatistics and data retrieval.

1973 • 476 citations

cis-Dichlorodiammineplatinum(II): combination chemotherapy and cross-resistance studies with tumors of mice.

1979 • 405 citations

Alkylating agents in bronchogenic carcinoma

1969 • 353 citations

VP-16 and cisplatin as first-line therapy for small-cell lung cancer.

1985 • 301 citations

Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer.

1973 • 298 citations

Surgical resection in the management of small cell carcinoma of the lung

1982 • 255 citations

Intensive chemotherapy of small cell bronchogenic carcinoma.

1977 • 253 citations

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

1986 • 242 citations

Small-Cell Carcinoma of the Lung: Combined Chemotherapy and Radiation

1978 • 232 citations

Chemotherapy Alone or Chemotherapy with Chest Radiation Therapy in Limited Stage Small Cell Lung Cancer

1987 • 225 citations

Small cell lung cancer 1973–1983: Early progress and recent obstacles

1984 • 219 citations

Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: a preliminary report.

1984 • 206 citations

Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2- to 10-year survivors of small-cell lung cancer.

1985 • 194 citations

Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung

1979 • 190 citations

Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small-cell lung cancer.

1985 • 188 citations

Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.

1979 • 179 citations

Risk of brain metastasis from small cell carcinoma of the lung related to length of survival and prophylactic irradiation.

1981 • 153 citations

cis-Dichlorodiammineplatinum(II) and VP-16-213: an active induction regimen for small cell carcinoma of the lung.

1979 • 153 citations

Carboplatin: a very active new cisplatin analog in the treatment of small cell lung cancer.

1985 • 151 citations

Successful treatment of resistant germinal neoplasms with VP-16 and cisplatin: results of a Southeastern Cancer Study Group trial.

1985 • 144 citations

Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial.

1984 • 140 citations

Long-term disease-free survival in small-cell carcinoma of the lung: a study of clinical determinants.

1986 • 137 citations

Intracranial metastases in small cell carcinoma of the lung. Correlation of clinical and autopsy findings

1982 • 133 citations

Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations.

1982 • 131 citations

Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer

1983 • 126 citations

Lung cancer: Clinical trial of radiotherapy alone vs. Radiotherapy plus cyclophosphamide

1972 • 123 citations

Small cell lung cancer

1979 • 119 citations

Neurotoxicity in long-term survivors of small cell lung cancer

1986 • 115 citations

Combined modality induction therapy without maintenance chemotherapy for small cell carcinoma of the lung.

1984 • 114 citations

Small cell bronchogenic carcinoma: a distinct clinicopathologic entity.

1978 • 114 citations

Prognostic implications of stage of disease and sites of metastases in patients with small cell carcinoma of the lung treated with intensive combination chemotherapy.

1981 • 114 citations

Treatment of bronchogenic carcinoma

1977 • 113 citations

Long-term results in combined-modality treatment of small cell carcinoma of the lung.

1978 • 112 citations

Patients with Small-Cell Lung Cancer Treated with Combination Chemotherapy with or without Irradiation

1985 • 111 citations

The superiority of combination chemotherapy over single agent chemotherapy in small cell lung carcinoma

1979 • 111 citations

Chemotherapy of Advanced Small-Cell Anaplastic Carcinoma

1978 • 110 citations

Follow-up neurological evaluation in patients with small cell lung carcinoma treated with prophylactic cranial irradiation and chemotherapy

1981 • 109 citations

Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma.

1983 • 109 citations

Prophylactic irradiation in bronchogenic small cell anaplastic carcinoma. A comparative trial of localized versus extensive radiotherapy including prophylactic brain irradiation in patients receiving combination chemotherapy

1980 • 109 citations

Role of radiation therapy in small cell anaplastic carcinoma of the lung.

1983 • 107 citations

Small-Cell Carcinoma of the Lung: Therapeutic Management

1978 • 106 citations

Staging procedures and prognostic features in small cell anaplastic bronchogenic carcinoma.

1978 • 105 citations

Co-trimoxazole prophylaxis during high-dose chemotherapy of small-cell lung cancer.

1985 • 104 citations

Alternating radiotherapy and chemotherapy schedules in small cell lung cancer, limited disease

1985 • 100 citations

Small cell lung cancer: Analysis of treatment factors contributing to prolonged survival

1981 • 96 citations

Survival after resection of small cell carcinoma of the bronchus.

1980 • 93 citations

Reduction in local recurrence and improved survival in surgically treated patients with small cell lung cancer

1983 • 92 citations

Staging and prognostic factors in small cell carcinoma of the lung.

1983 • 89 citations

Combination chemotherapy of advanced lung cancer.A randomized trial

1976 • 89 citations

Morphologic variations of small cell lung cancer: A histopathologic study of pretreatment and posttreatment specimens in 104 patients

1986 • 89 citations

High-dose intensification therapy with autologous bone marrow support for limited small-cell bronchogenic carcinoma.

1986 • 87 citations

Chemotherapy versus chemotherapy plus irradiation in limited small cell lung cancer. Results of a controlled trial with 5 years follow-up

1986 • 86 citations

Comparison of symptomatic and prophylactic irradiation of brain metastases from oat cell carcinoma of the lung

1981 • 86 citations

“The state of the art” toward defining the role of radiation therapy in the management of small cell bronchogenic carcinoma

1980 • 85 citations

Implications of kinetic heterogeneity in clinical oncology.

1985 • 84 citations

A randomized study: Small cell anaplastic lung cancer treated by combination chemotherapy and adjuvant radiotherapy

1980 • 83 citations

Thoracic and elective brain irradiation with concomitant or delayed multiagent chemotherapy in the treatment of localized small cell carcinoma of the lung: A randomized prospective study by the southeastern cancer study group

1981 • 80 citations

Increased incidence of acute nonlymphocytic leukemia following therapy in patients with small cell carcinoma of the lung.

1984 • 80 citations

Histopathologic classification of small cell carcinoma of the lung. Comments based on an interobserver examination

1982 • 76 citations

High-dose cyclophosphamide with autologous bone marrow rescue after conventional chemotherapy in the treatment of small cell lung carcinoma

1985 • 75 citations

The role of surgery in the management of selected patients with small-cell carcinoma of the lung.

1987 • 75 citations

Acute nonlymphocytic leukemia, preleukemia, and solid tumors following intensive chemotherapy of small cell carcinoma of the lung

1985 • 74 citations

Small Cell Bronchogenic Carcinoma: A Review of Therapeutic Results

1981 • 74 citations

Teniposide (VM-26), an overlooked highly active agent in small-cell lung cancer. Results of a phase II trial in untreated patients.

1986 • 73 citations

Long-term survival and toxicity in small cell lung cancer

1984 • 72 citations

Cyclophosphamide and CCNU in the treatment of inoperable small cell carcinoma and adenocarcinoma of the lung.

1976 • 72 citations

Long-term survival in small-cell carcinoma of the lung: a population experience.

1985 • 72 citations

Small-Cell Carcinoma of Lung: Reinduction Therapy After Late Relapse

1983 • 71 citations

Prospective evaluation of changes in computed cranial tomography in patients with small cell lung carcinoma treated with chemotherapy and prophylactic cranial irradiation.

1984 • 71 citations

VP-16 alone and in combination with cisplatin in previously treated patients with small cell lung cancer

1984 • 68 citations

Cisplatin, adriamycin, and etoposide (cav) for remission induction of small-cell bronchogenic carcinoma. Evaluation of efficacy and toxicity and pilot study of a “late intensification” with autologous bone-marrow rescue

1982 • 67 citations

Pulmonary toxicity with combined modality therapy for limited stage small-cell lung cancer.

1986 • 66 citations

Adverse prognostic effect of N2 disease in treated small cell carcinoma of the lung

1984 • 66 citations

Continuous versus alternating combination chemotherapy for advanced small cell carcinoma of the lung.

1983 • 66 citations

High-dose cyclophosphamide in small-cell carcinoma of the lung.

1985 • 65 citations

High-dose chemotherapy and autologous bone marrow transplantation for the treatment of small cell lung carcinoma

1983 • 65 citations

Maintenance chemotherapy for anaplastic small cell carcinoma of the bronchus: A randomised, controlled trial

1986 • 64 citations

Tumor stem cell heterogeneity: implications with respect to classification of cancers by chemotherapeutic effect.

1984 • 64 citations

Results of whole-brain irradiation for metastases from small cell carcinoma of the lung.

1980 • 64 citations

Current status of therapy for small cell carcinoma of the lung

1984 • 63 citations

The Feasibility of Adjuvant Surgery in Limited-Stage Small Cell Carcinoma: A Prospective Evaluation

1984 • 62 citations

Long-term survivors of small cell carcinoma of the lung

1985 • 60 citations

Mortality and morbidity in long-term surviving patients treated with chemotherapy with or without irradiation for small-cell lung cancer.

1986 • 59 citations

Non-small-cell lung cancer. Major cause of late mortality in patients with small cell lung cancer

1986 • 57 citations

Intensive chemoradiotherapy with autologous marrow transplantation for small cell carcinoma of the lung.

1983 • 57 citations

Randomized study of high-dose versus low-dose methotrexate in the treatment of extensive small cell lung cancer

1982 • 57 citations

Morbidity in long-term survivors of small cell carcinoma of the lung

1984 • 56 citations

Morbidity of cranial relapse in small cell lung cancer and the impact of radiation therapy

1987 • 56 citations

High-dose induction chemotherapy with cyclophosphamide, etoposide, and cisplatin for extensive-stage small-cell lung cancer.

1987 • 54 citations

The role of radiation therapy in the treatment of small cell lung cancer

1985 • 52 citations

Phase II clinical trial of weekly administration of VP-16-213 in small cell bronchogenic carcinoma.

1977 • 52 citations

Effect of initial resection of small-cell carcinoma of the lung: a review of Southwest Oncology Group Study 7628.

1985 • 51 citations

Etoposide (VP-16) in the treatment of lung cancer

1983 • 50 citations

Late intensification in small-cell lung cancer: a phase I study of high doses of cyclophosphamide and etoposide with autologous bone marrow transplantation.

1985 • 49 citations

Combined modality treatment of regional small cell unidifferentiated carcinoma of the lung: A cooperative study of the RTOG and ECOG

1983 • 48 citations

Treatment of extensive stage small cell bronchogenic carcinoma

1983 • 48 citations

Combined modality treatment of extensive small cell lung cancer: a Southwest Oncology Group study.

1984 • 47 citations

VP-16-213 in combination chemotherapy with chest irradiation for small-cell lung cancer: a randomized trial of the Piedmont Oncology Association.

1984 • 46 citations

Influence of surgical resection prior to chemotherapy on the long-term results in small cell lung cancer. A study of 150 operable patients

1986 • 46 citations

Combination chemotherapy in small cell lung carcinoma: A randomized study of two intensive regimens

1984 • 45 citations

Acute leukemia following intensive therapy for small-cell carcinoma of the lung

1982 • 43 citations

Chemotherapy versus chemoimmunotherapy for small-cell undifferentiated carcinoma of the lung

1980 • 42 citations

Addition of etoposide to cyclophosphamide, doxorubicin and vincristine for remission induction and survival in patients with small cell lung cancer

1987 • 40 citations

Diffuse aggressive lymphomas: a curable subset of non-Hodgkin's lymphomas.

1986 • 39 citations

Intensive induction chemotherapy in 54 patients with small cell carcinoma of the lung.

1981 • 39 citations

Extensive-stage small-cell bronchogenic carcinoma: intensive induction chemotherapy with high-dose cyclophosphamide plus high-dose etoposide.

1985 • 38 citations

Etoposide and cisplatin salvage chemotherapy for small cell lung cancer

1985 • 38 citations

"Salvage" radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy.

1983 • 37 citations

Cyclic alternating 'non-cross resistant' chemotherapy in the management of small cell anaplastic carcinoma of the lung

1984 • 37 citations

Intermittent high-dose cyclophosphamide chemotherapy for small cell carcinoma of the lung.

1978 • 36 citations

Influence of chest radiotherapy in frequency and patterns of chest relapse in disseminated small cell lung carcinoma. A Southwest oncology group study

1982 • 36 citations

Treatment policy of surgery in small cell carcinoma of the lung: retrospective analysis of a series of 874 consecutive patients.

1985 • 35 citations

Initial therapy with cisplatin plus VP-16 in small-cell lung cancer.

1986 • 35 citations

Alternating chemotherapy and thoracic radiotherapy with concurrent cisplatin-etoposide for limited-stage small-cell carcinoma of the lung.

1986 • 33 citations

Combination cyclophosphamide, adriamycin, and vincristine rapidly alternating with combination cisplatin and VP-16 in treatment of small cell lung cancer

1985 • 32 citations

Acute nonlymphocytic leukemia after treatment of small cell lung cancer

1986 • 29 citations

Disturbing central nervous system complications following combination chemotherapy and prophylactic whole-brain irradiation in patients with small cell lung cancer.

1985 • 29 citations

Long-term survival five years or more after combination chemotherapy and radiotherapy for small cell lung carcinoma

1981 • 29 citations

The role of consolidation irradiation in combined modality therapy of small cell carcinoma of the lung

1982 • 29 citations

Effect of histologically verified TNM stage on disease control in treated small cell carcinoma of the lung

1985 • 29 citations

Brain Metastases in Small Cell Carcinoma of the Lung

1979 • 29 citations

Randomized dose-response evaluation of etoposide in small cell carcinoma of the lung: A southeastern cancer study group trial

1987 • 28 citations

High-dose cyclophosphamide and VP 16 as late dosage intensification therapy for small cell carcinoma of lung

1985 • 27 citations

Changes in the relative risk and sites of central nervous system metastasis with effective combined chemotherapy and radiation therapy for small cell carcinoma of the lung*

1983 • 26 citations

Three months' treatment with cyclophosphamide, VP-16-213 followed by methotrexate and thoracic radiotherapy for small cell lung cancer

1985 • 25 citations

Phase II study of teniposide in small cell carcinoma of the lung.

1984 • 25 citations

Second primary bronchogenic carcinomas after small cell carcinoma

1984 • 25 citations

Intensive alternating chemotherapy regimen in small cell carcinoma of the lung.

1985 • 25 citations

Doxorubicin, cyclophosphamide, etoposide and platinum, doxorubicin, cyclophosphamide and etoposide for small-cell carcinoma of the lung.

1986 • 24 citations

Total body irradiation vs. chemotherapy as a systemic adjuvant for small cell carcinoma of the lung

1979 • 23 citations

Hemibody radiation, an active therapeutic modality for the management of patients with small cell lung cancer

1983 • 22 citations

New drugs in small-cell lung cancer

1986 • 21 citations

Effects of intensive induction chemotherapy for extensive-disease small cell bronchogenic carcinoma in protected environment-prophylactic antibiotic units

1984 • 21 citations

A 10-year experience with combined modality therapy for stage III small cell lung carcinoma

1986 • 20 citations

Long-term survival in limited-stage small cell lung carcinoma: Experience in Rochester, New York from 1975 to 1981

1986 • 20 citations

Upper hemibody and local chest irradiation as consolidation following response to high-dose induction chemotherapy for small cell bronchogenic carcinoma--a pilot study.

1982 • 20 citations

Preliminary report on “one-time” and high dose irradiation of the upper and lower half-body in patients with small cell lung cancer

1983 • 20 citations

Small-cell lung cancer: a 10-year perspective.

1986 • 18 citations

Intensive induction chemotherapy for small cell anaplastic carcinoma of the lung

1986 • 18 citations

Combined alkylators and multiple-site irradiation for extensive small cell lung cancer: A southwest oncology group study

1987 • 15 citations

Phase II trial of etoposide in previously treated small cell carcinoma of the lung.

1984 • 14 citations

Cisplatin plus VP-16 in small-cell lung cancer.

1986 • 13 citations

Comparison of chemotherapy alone versus chemotherapy and radiation therapy of extensive small cell carcinoma of the lung

1983 • 12 citations

Cyclic alternating chemotherapy for small cell carcinoma of the lung

1986 • 10 citations

Total body irradiation in oat cell carcinoma of the bronchus

1981 • 9 citations

The influence of myelosuppression on the response to chemotherapy in small cell bronchogenic carcinoma

1984 • 9 citations

Small cell anaplastic carcinoma of the lung. The Cancer and Leukemia Group B Experience.

1982 • 6 citations

Etoposide in small cell lung cancer resistant to prior chemotherapy.

1983 • 5 citations

Outpatient administration of VP-16 and cisplatin.

1986 • 3 citations

A comparison between a single agent short course chemotherapy regimen and a quadruple prolonged course regimen for small-cell bronchogenic carcinoma of limited extent

1983 • 2 citations