Mechanism-based inactivation of lacrimal-gland peroxidase by phenylhydrazine: a suicidal substrate to probe the active site

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Cleavage of the haem-protein link by acid methylethylketone

1959 • 1,226 citations

Hematin compounds and bile pigments

1949 • 921 citations

Spin trapping of superoxide and hydroxyl radical: Practical aspects

1980 • 861 citations

Generation of Hydrogen Peroxide in Erythrocytes by Hemolytic Agents^*

1964 • 360 citations

Origin of the heme Cotton effects in myoglobin and hemoglobin

1971 • 339 citations

The Lactoperoxidase System: Chemistry and Biological Significance

1985 • 230 citations

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

1976 • 228 citations

Protein control of prosthetic heme reactivity. Reaction of substrates with the heme edge of horseradish peroxidase.

1987 • 216 citations

Reaction of myoglobin with phenylhydrazine: a molecular doorstop

1984 • 190 citations

Crystal structure of lignin peroxidase.

1993 • 184 citations

Histidine 52 is a critical residue for rapid formation of cytochrome c peroxidase compound I

1993 • 176 citations

N-Phenylprotoporphyrin IX formation in the hemoglobin-phenylhydrazine reaction. Evidence for a protein-stabilized iron-phenyl intermediate.

1982 • 153 citations

Horseradish Peroxidase His-42 → Ala, His-42 → Val, and Phe-41 → Ala Mutants

1995 • 147 citations

A spectrophotometric assay for iodide oxidation by thyroid peroxidase

1962 • 147 citations

Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

1975 • 136 citations

Hydroxyl radical mediated damage to proteins, with special reference to the crystallins

1992 • 134 citations

Enzymatic activation of hydrazine derivatives. A spin-trapping study.

1983 • 123 citations

On the State of the Iron and the Nature of the Ligand in Oxyhemoglobin

1970 • 112 citations

Biological magnetic resonance

1989 • 100 citations

Phenyl radical production during the oxidation of phenylhydrazine and in phenylphydrazine‐induced haemolysis

1981 • 97 citations

The mechanism of superoxide anion generation by the interaction of phenylhydrazine with hemoglobin.

1976 • 93 citations

Binding of hydrogen donors to horseradish peroxidase: A spectroscopic study

1976 • 86 citations

Inactivation of catalase by phenylhydrazine. Formation of a stable aryl-iron heme complex.

1983 • 79 citations

The reaction of phenylhydrazine with microsomal cytochrome P-450. Catalysis of heme modification.

1982 • 77 citations

Mitochondrial Monoamine Oxidase

1974 • 74 citations

Lactoperoxidase: Identification and Isolation from Harderian and Lacrimal Glands

1966 • 74 citations

Equilibria between Horseradish Peroxidase and Aromatic Donors.

1978 • 66 citations

Lactoperoxidase haem, an iron-porphyrin thiol

1987 • 59 citations

Chemical modification of chloroperoxidase with diethylpyrocarbonate. Evidence for the presence of an essential histidine residue.

1990 • 59 citations

LOCALIZATION OF ENDOGENOUS PEROXIDASE IN RAT EXORBITAL LACRIMAL GLAND

1971 • 55 citations

Binding of thiocyanate to lactoperoxidase: proton and nitrogen-15 nuclear magnetic resonance studies

1989 • 54 citations

Genotoxicity of the Antihypertensive Drugs Hydralazine and Dihydralazine

1980 • 50 citations

Interaction of aromatic donor molecules with lactoperoxidase probed by optical difference spectra

1989 • 43 citations

Proton nuclear magnetic resonance studies on the iodide binding by horseradish peroxidase.

1987 • 40 citations

Chemical and kinetic evidence for an essential histidine in horseradish peroxidase for iodide oxidation.

1992 • 37 citations

Inactivation of myoglobin by ortho-substituted arylhydrazines. Formation of prosthetic heme aryl-iron but not N-aryl adducts

1985 • 36 citations

Studies on the control of hypertension by hyphex. III. Pharmacological and chemical observations on 1-hydrazinophthalazine.

1954 • 34 citations

Enzyme-activated/mechanism-based inhibitors.

1987 • 33 citations

Evidence of a hydrazine-reactive group at the active site of the nonheme portion of horseradish peroxidase

1970 • 33 citations

Use of a thermal inactivation technique to obtain binding constants for the Escherichia coli valyl-tRNA synthetase

1972 • 31 citations

Proton and iodine-127 nuclear magnetic resonance studies on the binding of iodide by lactoperoxidase

1987 • 29 citations

The inactivation of lactoperoxidase and the acyl phosphatase activity of oxidized glyceraldehyde-3-phosphate dehydrogenase by phenylhydrazine and phenyldiimide

1973 • 28 citations

Tissue distribution of constitutive and induced soluble peroxidase in rat

1992 • 26 citations

Genetic effects of hydralazine

1979 • 24 citations

Horseradish peroxidase-catalyzed conversion of iodine to iodide in presence of EDTA and H2O2.

1986 • 21 citations

Chemical Modification by Diethylpyrocarbonate of an Essential Histidine Residues in 3-Ketovalidoxylamine A C-N Lyase

1986 • 21 citations

Characterization of sheep lacrimal-gland peroxidase and its major physiological electron donor

1996 • 15 citations

Circular dichroism studies on native and artificial horseradish peroxidases.

1977 • 14 citations

The fine structural localization of peroxidase activity in goblet cells of the conjunctival epithelium of rats.

1976 • 14 citations

Iodide modulation of the EDTA-induced iodine reductase activity of horseradish peroxidase by interaction at or near the EDTA-binding site

1993 • 8 citations

Inhibition of thyroid iodide peroxidase in vivo and in vitro by iproniazid

1970 • 7 citations