Safety of Trypsin Inhibitors in the Diet: Effects on the Rat Pancreas of Long-Term Feeding of Soy Flour and Soy Protein Isolate

Official Methods of Analysis of

1980 • 61,391 citations

Multiple Range and Multiple F Tests

1955 • 22,685 citations

Analysis of Categorical Data by Linear Models

1969 • 1,545 citations

The Laboratory Rat

2006 • 1,099 citations

Toxic constituents of plant foodstuffs

1981 • 908 citations

Determination of trypsin inhibitor activity of soy products: a collaborative analysis of an improved procedure

1974 • 868 citations

evaluation of natural vs. synthetic substrates for measuring the antitryptic activity of soybean samples

1969 • 510 citations

Toxic constituents of plant foodstuffs

1981 • 510 citations

Feedback Regulation of Pancreatic Enzyme Secretion as a Mechanism for Trypsin Inhibitor-Induced Hypersecretion in Rats

1972 • 449 citations

Trypsin inhibitors in soy products: modification of the standard analytical procedure.

1981 • 289 citations

Hormonal Control of Pancreatic Growth

1973 • 243 citations

Contribution of Trypsin Inhibitors to the Deleterious Effects of Unheated Soybeans Fed to Rats

1973 • 227 citations

Statistics in Biology; Vol. 1

1968 • 226 citations

Neoplasms Observed in Untreated and Corn Oil Gavage Control Groups of F344/N Rats and (C57BL/6N × C3H/HeN)F1 (B6C3F1) Mice

1985 • 172 citations

Cancers of the pancreas and biliary tract: epidemiological considerations.

1975 • 145 citations

Hyperplastic, Preneoplastic and Neoplastic Lesions Found in 83 Human Pancreases

1982 • 138 citations

The Effects of Long-Term Feeding of Soya Flour on the Rat Pancreas

1980 • 132 citations

Effect of Raw Soybean Meal and Amino Acids on Pancreatic Hypertrophy in Rats

1960 • 132 citations

Epidemiology of pancreatic cancer

1984 • 130 citations

Protein, as a Regulator of Pancreatic Enzyme Secretion in the Rat

1973 • 130 citations

Antinutrients and natural toxicants in foods

1981 • 129 citations

Pancreatic enzyme response to a liquid meal and to hormonal stimulation. Correlation with plasma secretin and cholecystokinin levels.

1985 • 127 citations

Factors Involved in the Intestinal Feedback Regulation of Pancreatic Enzyme Secretion in the Rat

1975 • 126 citations

Pancreatic carcinoma in azaserine-treated rats: Induction, classification and dietary modulation of incidence

1981 • 122 citations

Pancreatic carcinogenesis-enhancement by cholecystokinin in the hamster-nitrosamine model

1985 • 119 citations

Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat.

1981 • 116 citations

An epidemiological evaluation of the causes of cancer of the pancreas.

1975 • 112 citations

Ductal metaplasia of human exocrine pancreas and its association with carcinoma.

1985 • 104 citations

Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor

1976 • 92 citations

Focal acinar cell dysplasia in human pancreas

1980 • 91 citations

Physiological properties of soybean trypsin inhibitors and their relationship to pancreatic hypertrophy and growth inhibition of rats.

1965 • 83 citations

Potentiation of the action of azaserine on the rat pancreas by raw soya bean flour

1977 • 64 citations

Inhibition of Intraduodenal Trypsin Does Not Stimulate Exocrine Pancreatic Secretion in Man

1983 • 63 citations

The release of rat intestinal cholecystokinin after oral trypsin inhibitor measured by bio‐assay.

1981 • 62 citations

Effects of soybean flour on the pancreas of rats.

1984 • 59 citations

Hypertrophy and Hyperplasia in the Endocrine and Exocrine Pancreas of Rats Fed Soybean Trypsin Inhibitor or Repeatedly Injected with Pancreozymin

1976 • 58 citations

Biological threshold levels of soybean trypsin inhibitors by rat bioassay

1975 • 57 citations

Carcinogenic Effects of Di(2-hydroxypropyl)nitrosamine (DHPN) in Male Wistar Rats: Promotion of Pancreatic Cancer by a Raw Soya Flour Diet

1979 • 55 citations

Regulation of proteolytic enzyme activities and mRNA concentrations in rat pancreas by food content

1985 • 53 citations

The Pancreatic Secretion of Enzymes in Rats Treated with Soybean Diet

1974 • 52 citations

Trypsin inhibitor activity of conventional foods which are part of the British diet and some soya products

1981 • 51 citations

A further physiological role for naturally occurring trypsin inhibitors: the evidence for a trophic stimulant of the pancreatic acinar cell

1969 • 50 citations

Proliferative lesions of the exocrine pancreas in male F344/N rats.

1984 • 48 citations

Pancreatic growth and cell turnover in the rat fed raw soya flour.

1982 • 46 citations

Pancreatic Secretion by Nonparallel Exocytosis: Potential Resolution of a Long Controversy

1985 • 45 citations

Effect of parenteral amino acids on human pancreatic exocrine secretion

1985 • 43 citations

The effect of long-term feeding of soya-bean flour diets on pancreatic growth in the rat

1982 • 43 citations

The Effect of Raw Soybean Meal and Trypsin Inhibitor Diets on the Intestinal and Pancreatic Nitrogen in the Rat

1957 • 42 citations

The USDA trypsin inhibitor study. I. Background, objectives, and procedural details

1985 • 41 citations

Regulation of pancreatic enzyme levels by trypsin inhibitors

1970 • 40 citations

Further Studies of the Effects of Raw Soya Flour on the Rat Pancreas

1982 • 40 citations

The USDA trypsin inhibitor study. IV. The chronic effects of soy flour and soy protein isolate on the pancreas in rats after two years

1985 • 39 citations

The Effect of the Long-Term Feeding of Raw Soyflour on the Pancreas of the Mouse and Hamster

1986 • 35 citations

Factors in Whole-egg Protein Influencing Dietary Induction of Increases in Enzyme and RNA Levels in Rat Pancreas

1969 • 32 citations

Regulatory Effects on the Pancreas of Intraduodenal Pancreatic Juice and Trypsin in the Syrian Golden Hamster

1983 • 31 citations

Latitude and pancreatic cancer.

1985 • 30 citations

Interaction of Dietary Protein and Trypsin Inhibitor on Plasma Cholecystokinin and Pancreatic Growth in Rats

1986 • 30 citations

The Effect of Feeding Soybean Trypsin Inhibitor and Repeated Injections of Cholecystokinin on Rat Pancreas

1984 • 29 citations

Effects of a Cholecystokinin-Like Peptide on DNA and Polyamine Synthesis in the Rat Pancreas

1985 • 28 citations

The USDA trypsin inhibitor study. II. Timed related biochemical changes in the pancreas of rats

1985 • 28 citations

Role of cholecystokinin in pancreatic exocrine response to intraluminal amino acids and fat

1985 • 27 citations

Rapid changes in pancreatic DNA, RNA and protein in the rat during pancreatic enlargement and involution.

1981 • 25 citations

Effect of proglumide on rat pancreatic growth

1985 • 24 citations

Human pancreatic and biliary responses to physiological concentrations of cholecystokinin octapeptide

1985 • 22 citations

Pathologic and biochemical effects of azaserine in inbred Wistar/Lewis rats and noninbred CD-1 mice.

1980 • 21 citations

Growth retardation and pancreatic enlargement in rats due to p-aminobenzamide

1968 • 20 citations

The USDA trypsin inhibitor study. III. Sequential development of pancreatic pathology in rats

1985 • 19 citations

Ductular origin of pancreatic cancer and its multiplicity in man comparable to experimentally induced tumors. A preliminary study

1979 • 18 citations

Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog

1984 • 14 citations

Régulation de la sécrétion pancréatique par rétroaction négative et hormones gastro-intestinales plasmatiques chez le porc

1985 • 13 citations

The failure of long‐term feeding of raw soy flour, in the presence or absence of Azaserine, to induce carcinogenic changes in the mouse pancreas

1986 • 11 citations

Changes in Rat Pancreatic Protein Synthesis After a Single Feeding with Diets Containing Raw or Heated Soybeans

1978 • 10 citations

Pancreatic tumors induced by a single intraperitoneal injection of azaserine in partial pancreatectomized rats

1980 • 9 citations

Induction and differentiation of exocrine pancreatic tumors in the rat

1985 • 8 citations

Interaction of Dietary Fat and Soybean Isolate (SBI) on Azaserine-induced Pancreatic Carcinogenesis

1985 • 7 citations

Development of the pancreas during gestation and lactation in swine

1982 • 6 citations

The effects of caerulein on exocrine pancreatic secretion in pigs

1983 • 5 citations

Does a negative feedback system for the control of pancreatic exocrine secretion exist and is it of any clinical significance?

1980 • 4 citations

Recent advances in pancreatic physiology: summary of a conference.

1981 • 4 citations