The CD11/CD18 Leukocyte Glycoprotein Deficiency

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

A monoclonal antibody reactive with human peripheral blood monocytes.

1980 • 854 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.

1983 • 674 citations

The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features

1985 • 644 citations

Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.

1982 • 615 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Antigens on human monocytes identified by monoclonal antibodies.

1981 • 583 citations

Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis.

1984 • 495 citations

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.

1986 • 487 citations

Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin as functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b.

1985 • 433 citations

Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies.

1986 • 423 citations

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

1984 • 391 citations

A human lymphocyte‐associated antigen involved in cell‐mediated lympholysis

1983 • 315 citations

An Inherited Abnormality of Neutrophil Adhesion

1980 • 306 citations

Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

1983 • 305 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence.

1984 • 273 citations

The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro

1985 • 268 citations

Neutrophil Actin Dysfunction and Abnormal Neutrophil Behavior

1974 • 266 citations

Increased Expression of an Adhesion-Promoting Surface Glycoprotein in the Granulocytopenia of Hemodialysis

1985 • 265 citations

Characterization of a phenotypically distinct subpopulation of Leu-2+ cells that suppresses T cell proliferative responses.

1983 • 251 citations

Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.

1984 • 249 citations

T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies.

1986 • 246 citations

LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation.

1984 • 227 citations

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

1984 • 224 citations

Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein

1982 • 193 citations

Deficiency of a surface membrane glycoprotein (Mo1) in man.

1984 • 192 citations

Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

1982 • 180 citations

Analysis of Antigenic Determinants on Human Monocytes and Macrophages

1982 • 179 citations

Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.

1986 • 174 citations

Monoclonal antibody-defined functional epitopes on the adhesion- promoting glycoprotein complex (CDw18) of human neutrophils

1986 • 173 citations

Characterization of Monoclonal Antibodies Against Cell Surface Molecules Associated with Cytotoxic Activity of Natural and Activated Killer Cells and Cloned CTL Lines

1983 • 155 citations

Neutrophil-induced injury of rat pulmonary alveolar epithelial cells.

1986 • 153 citations

The human lymphocyte function-associated (HLFA) antigen and a related macrophage differentiation antigen (HMac-1): functional effects of subunit-specific monoclonal antibodies.

1985 • 152 citations

pl50/95, Third member of the LFA‐1/CR₃ polypeptide family identified by anti‐Leu M5 monoclonal antibody

1985 • 149 citations

Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency.

1984 • 146 citations

DELAYED SEPARATION OF THE UMBILICAL CORD, WIDESPREAD INFECTIONS, AND DEFECTIVE NEUTROPHIL MOBILITY

1979 • 143 citations

Identification of a Cell Surface Protein Complex Mediating Phorbol Ester‐Induced Adhesion (Binding) among Human Mononuclear Leukocytes

1985 • 139 citations

ABSENCE OF MONOCLONAL-ANTIBODY-DEFINED PROTEIN COMPLEX IN BOY WITH ABNORMAL LEUCOCYTE FUNCTION

1984 • 135 citations

Membrane Glycoproteins

1976 • 128 citations

Human monocyte adherence to cultured vascular endothelium: monoclonal antibody-defined mechanisms.

1985 • 127 citations

p150,95, the third member of the Mac-1, LFA-1 human leukocyte adhesion glycoprotein family.

1986 • 125 citations

Structural Analysis of Differentiation Antigens Mol and Mo2 On Human Monocytes

1982 • 118 citations

Both Fc receptors and lymphocyte‐function‐associated antigen 1 on human Tγ lymphocytes are required for antibody‐dependent cellular cytotoxicity (killer cell activity)

1984 • 112 citations

BONE-MARROW TRANSPLANTATION FOR INBORN ERROR OF PHAGOCYTIC CELLS ASSOCIATED WITH DEFECTIVE ADHERENCE, CHEMOTAXIS, AND OXIDATIVE RESPONSE DURING OPSONISED PARTICLE PHAGOCYTOSIS

1983 • 106 citations

Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein

1985 • 106 citations

Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1

1985 • 98 citations

LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.

1985 • 93 citations

Characterization of human leukocyte differentiation antigens

1987 • 93 citations

Adhesion of T lymphocytes to human endothelial cells is regulated by the LFA-1 membrane molecule

1986 • 89 citations

Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1.

1985 • 83 citations

Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions.

1985 • 75 citations

The role of neutrophil membrane glycoprotein 150 (Gp-150) in neutrophil-mediated endothelial cell injury in vitro.

1985 • 71 citations

Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA.

1987 • 71 citations

The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150,95 in humans is associated with defective antibody-dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo.

1986 • 63 citations

Defective initiation of the metabolic stimulation in phagocytizing granulocytes: a new congenital defect.

1976 • 62 citations

Human C5a modulates monocyte Fc and C3 receptor expression.

1985 • 62 citations

Abnormal adherence-related functions of neutrophils, monocytes, and Epstein-Barr virus-transformed B cells in a patient with C3bi receptor deficiency

1985 • 59 citations

Studies on the interaction between GP-18-0-deficient neutrophils and vascular endothelium

1982 • 55 citations

Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

1981 • 53 citations

Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.

1985 • 52 citations

Recurrent severe infections in a child with abnormal leukocyte function: possible relationship to increased microtubule assembly

1978 • 42 citations

Decrease of the major high molecular weight surface glycoprotein of human granulocytes in monosomy-7 associated with defective chemotaxis

1979 • 36 citations

An Abnormality of Neutrophil Adhesion: Autosomal Recessive Inheritance Associated with Missing Neutrophil Glycoproteins

1984 • 30 citations

Defective membrane expression of the LFA‐1 complex may be secondary to the absence of the β chain in a child with recurrent bacterial infection

1986 • 28 citations

Defective immune interferon production and natural killer activity associated with poor neutrophil mobility and delayed umbilical cord separation.

1982 • 27 citations

Delayed separation of the umbilical cord, severe widespread infections, and immunodeficiency.

1981 • 22 citations

Glycoprotein-180 deficiency: genetics and abnormal neutrophil activation

1985 • 20 citations

NEW FAMILIAL DEFECT IN MICROBICIDAL FUNCTION OF POLYMORPHONUCLEAR LEUCOCYTES

1975 • 18 citations

Disorders of Polymorphonuclear Leukocyte Function

1985 • 6 citations