Epitope affinity for MHC class I determines helper requirement for CTL priming

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

T and Tn, General Carcinoma Autoantigens

1984 • 998 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

1994 • 838 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.

1991 • 334 citations

Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells

1987 • 304 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.

1994 • 276 citations

The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.

1978 • 268 citations

Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

1994 • 233 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity

1977 • 215 citations

Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes

1990 • 208 citations

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

2000 • 201 citations

Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.

1990 • 199 citations

Identification of Db- and Kb-Restricted Subdominant Cytotoxic T-Cell Responses in Lymphocytic Choriomeningitis Virus-Infected Mice

1998 • 164 citations

Dendritic cells process exogenous viral proteins and virus‐like particles for class I presentation to CD8⁺ cytotoxic T lymphocytes

1996 • 149 citations

CD8+ T Cells Mediate CD40-independent Maturation of Dendritic Cells In Vivo

1999 • 145 citations

A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.

1977 • 122 citations

CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8⁺Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection

1998 • 120 citations

Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene.

1995 • 118 citations

TransfectedDrosophilacells as a probe for defining the minimal requirements for stimulating unprimed CD8⁺T cells

1996 • 117 citations

Relative contribution of "determinant selection" and "holes in the T-cell repertoire" to T-cell responses.

1989 • 115 citations

Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice.

1997 • 109 citations

Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.

1996 • 101 citations

Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events

1992 • 94 citations

Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway.

1996 • 92 citations

The Cytolytic T Lymphocyte Response to Trinitrophenyl-Modified Syngeneic Cells

1979 • 54 citations

The cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. II. Evidence for antigen-specific suppressor T cells.

1979 • 54 citations

The immune system as anti-tumor sentinel: molecular requirements for an anti-tumor immune response.

1999 • 50 citations

Specific Helper T Cells Permit Differentiation of Thymic Anti-Self-Trinitrophenyl Cytotoxic Precursor Cells

1979 • 43 citations

Cutting Edge: B Cells Promote CD8+ T Cell Activation in MRL-FaslprMice Independently of MHC Class I Antigen Presentation

2000 • 37 citations

Influence of strong CD4 epitope on long-term virus-specific cytotoxic T cell responses induced in vivo with peptides

1996 • 32 citations

Fine Specificity and MHC Restriction of Trinitrophenyl- Specific CTL

1999 • 22 citations

Synthesis of T-antigen-containing glycopeptides as potential cancer vaccines

1999 • 20 citations