Control of Plasma and Liver Triglyceride Kinetics by Carbohydrate Metabolism and Insulin

A RELATION BETWEEN NON-ESTERIFIED FATTY ACIDS IN PLASMA AND THE METABOLISM OF GLUCOSE

1956 • 3,458 citations

The Role of Lipids and Lipoproteins in Atherosclerosis

1950 • 808 citations

Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders

1967 • 746 citations

THE INFLUENCE OF DIETARY FATS ON SERUM-LIPID LEVELS IN MAN

1957 • 737 citations

UNESTERIFIED FATTY ACID IN HUMAN BLOOD PLASMA 1

1956 • 707 citations

DIETARY FAT AND DIETARY SUGAR IN RELATION TO ISCHÆMIC HEART-DISEASE AND DIABETES

1964 • 674 citations

Transport of Fatty Acids

1958 • 558 citations

Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro

1964 • 540 citations

Role of Insulin in Endogenous Hypertriglyceridemia*

1967 • 523 citations

Factors Influencing the Rates of Long-Chain Fatty Acid Oxidation and Synthesis in Mammalian Systems

1961 • 479 citations

Serum Triglycerides in Coronary Artery Disease

1959 • 440 citations

Effects of carbohydrates on secretion of insulin from isolated rat pancreas

1963 • 432 citations

The Effect of Nicotinic Acid on the Plasma Free Fatty Acids Demonstration of a Metabolic Type of Sympathicolysis

1962 • 410 citations

Metabolic and Hormonal Control of Phosphoenolpyruvate Carboxykinase and Malic Enzyme in Rat Liver

1963 • 388 citations

TISSUE DISTRIBUTION OF C14 AFTER THE INTRAVENOUS INJECTION OF LABELED CHYLOMICRONS AND UNESTERIFIED FATTY ACIDS IN THE RAT

1958 • 368 citations

Studies on the Metabolism of Adipose Tissue. XII. The Effects of Insulin and Epinephrine on Free Fatty Acid and Glycerol Production in the Presence and Absence of Glucose^*

1963 • 356 citations

Lipolytic activity of post-heparin plasma in hyperglyceridemia

1963 • 347 citations

Glucokinase and Hexokinase in Liver in Relation to Glycogen Synthesis

1963 • 343 citations

Variations in tissue contents of coenzyme A thio esters and possible metabolic implications

1964 • 343 citations

Effect of Insulin on Adenosine 3‘,5‘-Monophosphate in the Rat Epididymal Fat Pad

1966 • 340 citations

Formation and fate of endogenous triglycerides in blood plasma of rabbits

1962 • 340 citations

Serum lipids, hypertension and coronary artery disease

1961 • 330 citations

Effects of Diet and Insulin on Glucose-Adenosine Triphosphate Phosphotransferases of Rat Liver

1963 • 317 citations

Extent and Patterns of Adaptation of Enzyme Activities in Livers of Normal Rats Fed Diets High in Glucose and Fructose

1960 • 312 citations

Serum Lipids in Men with Myocardial Infarction

1960 • 305 citations

Particulate Fat in Lymph and Blood

1962 • 292 citations

The Hexosemonophosphate Shunt and Adaptive Hyperlipogenesis

1958 • 288 citations

An Abnormality of Nonesterified Fatty Acid Metabolism in Diabetes Mellitus

1958 • 277 citations

The Effect of Palmityl Coenzyme A on Glucose 6-Phosphate Dehydrogenase and Other Enzymes

1966 • 272 citations

THE BIOSYNTHESIS OF FATTY ACIDS IN RAT LIVER

1957 • 264 citations

Glucose, insulin, and triglyceride responses to high and low carbohydrate diets in man.

1966 • 261 citations

Insulin-dependent Synthesis of Liver Glucokinase in the Rat

1963 • 257 citations

THE INFLUENCE OF DIET ON SERUM-TRIGLYCERIDES

1961 • 255 citations

Regulation of phosphofructokinase activity by citrate in normal and diabetic muscle

1963 • 254 citations

Liver acetyl CoA carboxylase and fatty acid synthetase: Relative activities in the normal state and in hereditary obesity

1967 • 253 citations

Diabetic Lipemia

1967 • 251 citations

Studies on the Mechanism of Fatty Acid Synthesis

1962 • 246 citations

Biochemical mechanisms related to the homeostatic regulation of lipogenesis in animals

1962 • 242 citations

Relationship between Plasma Triglycerides and Removal of Chylomicrons*

1964 • 240 citations

Effect of nutrition on activity and release of lipase from rat adipose tissue

1959 • 236 citations

Kinetics of triglyceride turnover of very low density lipoproteins of human plasma.

1965 • 231 citations

Fatty acid synthesis during fat-free refeeding of starved rats

1965 • 227 citations

TWO BLOCKS IN CARBOHYDRATE UTILIZATION IN THE LIVER OF THE DIABETIC RAT

1951 • 226 citations

SERUM-TRIGLYCERIDE LEVELS IN SOUTH AFRICAN EUROPEANS AND BANTU AND IN ISCHÆMIC HEART-DISEASE

1960 • 226 citations

PREVIOUS NUTRITIONAL STATE AND GLUCOSE CONVERSION TO FATTY ACIDS IN LIVER SLICES

1950 • 225 citations

Hepatic Glucokinase in the Fed, Fasted, and Alloxan-Diabetic Rat

1960 • 224 citations

Fate of palmitate and of linoleate perfused through the isolated rat liver at high concentrations

1963 • 211 citations

BIOSYNTHESIS OF FATTY ACIDS BY CELL-FREE OR WATER-SOLUBLE ENZYME SYSTEMS

1952 • 207 citations

BIOSYNTHESIS OF LABELED FATTY ACIDS AND CHOLESTEROL IN EXPERIMENTAL DIABETES

1950 • 206 citations

Gluconeogenesis in the perfused liver

1966 • 200 citations

Inhibition of citrate-synthase by palmityl-coenzyme A

1963 • 199 citations

CITRATE AND THE CONVERSION OF CARBOHYDRATE INTO FAT. THE ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF STARVED AND RE-FED RATS

1965 • 197 citations

Antigenicity of insulin: diabetes induced by specific antibodies

1955 • 196 citations

Validation of an incompletely coupled two-compartment nonrecycling catenary model for turnover of liver and plasma triglyceride in man

1965 • 195 citations

THE INFLUENCE OF DIETARY CARBOHYDRATES ON THE LIPID PATTERN IN SERUM AND IN ADIPOSE TISSUE.

1964 • 194 citations

Nutrition-Endocrine Interrelationships in the Control of Fat Transport in Man

1960 • 192 citations

Recycling of Intravenously Injected Palmitic Acid‐l‐C¹⁴ as Esterified Fatty Acid in the Plasma of Rats and Turnover Rate of Plasma Triglycerides

1960 • 189 citations

HUMORAL CHANGES IN ARTERIOSCLEROSIS INVESTIGATIONS ON LIPIDS, FATTY ACIDS, KETONE BODIES, PYRUVIC ACID, LACTIC ACID, AND GLUCOSE IN THE BLOOD

1960 • 188 citations

Regulation of Fat Metabolism in the Liver

1967 • 186 citations

Fructose Metabolism of Adipose Tissue

1962 • 185 citations

Action of Insulin on Release of Fatty Acids From Tissue Stores

1957 • 184 citations

EFFECT OF DIABETES AND INSULIN ON THE ACTIVITY OF MYOCARDIAL AND ADIPOSE TISSUE LIPOPROTEIN LIPASE OF RATS*

1963 • 182 citations

THE INFLUENCE OF INSULIN ON GLUCOSE UTILIZATION IN ADIPOSE AND HEPATIC TISSUES IN VITRO

1954 • 174 citations

Studies on the Elimination of Exogenous Lipids from the Blood Stream. The Kinetics of the Elimination of a Fat Emulsion and of Chylomicrones in the Dog after Single Injection

1963 • 170 citations

STUDIES IN CARBOHYDRATE METABOLISM

1944 • 170 citations

SYNTHESIS OF RADIOACTIVE FATTY ACIDS IN VITRO AND ITS HORMONAL CONTROL

1951 • 168 citations

α-Glycerophosphate as regulatory factor in fatty acid esterification

1964 • 168 citations

De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production

1967 • 168 citations

Plasma Free Fatty Acids in Diabetic Acidosis and Starvation

1956 • 167 citations

The Significance of Blood Lipid Alterations in Diabetes Mellitus

1963 • 166 citations

THE INCORPORATION OF PLASMA FREE FATTY ACIDS INTO PLASMA TRIGLYCERIDES IN MAN*

1961 • 165 citations

Effect of fasting, epinephrine and glucose and insulin on hepatic uptake of nonesterified fatty acids

1960 • 165 citations

ROLE OF CYCLIC-3′,5′-AMP IN THE RESPONSE OF ADIPOSE TISSUE TO INSULIN

1966 • 165 citations

Effects of diet in essential hypertension

1950 • 164 citations

Relation between incorporation of triglyceride fatty acids and heparin-released lipoprotein lipase from adipose tissue slices

1962 • 162 citations

FASTING AND HEPATIC LIPOGENESIS FROM C14-ACETATE

1952 • 159 citations

Dietary Sugar in the Production of Hyperglyceridemia

1965 • 159 citations

Use of multicompartmental models to measure rates of triglyceride metabolism in rats

1964 • 158 citations

The nature of the epinephrine-induced hyperlipidemia in dogs and its modification by glucose

1959 • 158 citations

The Hyperlipemic Effect of a Low-fat, High-carbohydrate Diet in Diabetic Subjects

1961 • 155 citations

The removal of ¹⁴C‐labelled chylomicron fat from the circulation in rats

1957 • 155 citations

Role of the pituitary and the adrenal in the mobilization of free fatty acids and lipoproteins

1960 • 155 citations

Regulation of Hepatic Lipogenesis: The Influence of Dietary Fats

1958 • 153 citations

Pancreatic Islets in Mice with the Obese-hyperglycemic Syndrome: Lack of Effect of Carbutamide

1960 • 152 citations

Release and uptake of triglycerides by isolated perfused rat liver

1962 • 151 citations

LIPOGENESIS AND GLUCOSE OXIDATION IN THE LIVER OF THE ALLOXAN-DIABETIC RAT

1950 • 150 citations

EARLY EFFECTS OF FASTING AND OF CARBOHYDRATE INGESTION ON LIPIDS AND LIPOPROTEINS OF SERUM IN MAN

1957 • 150 citations

Effect of Glucose and Fructose Administration on Lipid Metabolism in the Rat

1968 • 150 citations

Localization of the Block in Lipogenesis Resulting from Feeding Fat

1963 • 149 citations

Familial diabetes mellitus in mice, associated with insulin resistance, obesity, and hyperplasia of the islands of langerhans.

1952 • 148 citations

Development of the obese-hyperglycaemic syndrome in mice

1968 • 147 citations

A Study of the Role of Palmityl Coenzyme A in Fatty Acid Synthesis by the Pigeon Liver System

1958 • 146 citations

SITES OF INITIAL REMOVAL OF CHYLOMICRON TRIGLYCERIDE FATTY ACIDS FROM THE BLOOD*

1962 • 143 citations

The Effect of Acute Insulin Deficiency in the Rat on Adipose Tissue Lipolytic Activity and Plasma Lipids

1963 • 142 citations

Serum Triglycerides in Health and Diabetes

1958 • 142 citations

Regulation of fatty acid synthesis at the acetyl-CoA carboxylation step

1965 • 142 citations

The Prolonged Effects of a Low Cholesterol, High Carbohydrate Diet Upon the Serum Lipids in Diabetic Patients

1963 • 140 citations

Effects of restriction of dietary fat and cholesterol upon serum lipids and lipoproteins in patients with hypertension

1955 • 138 citations

Biosynthesis of fatty acids: IV. Studies with inhibitors

1963 • 138 citations

The tissue distribution and oxidation of ¹⁴C‐labelled chylomicron fat injected intravenously in rats

1958 • 137 citations

PLASMA-INSULIN IN CORONARY HEART-DISEASE

1965 • 136 citations

Carbohydrate Metabolism in Two Forms of Hyperglyceridemia *

1964 • 136 citations

Vascular Disease and Serum Lipids in Diabetes Mellitus

1963 • 134 citations

STUDIES ON CARBOHYDRATE METABOLISM IN RAT LIVER SLICES

1955 • 134 citations

Increased Circulating Insulin-like Activity in Obese-Hyperglycæmic Mice

1959 • 134 citations

Mechanism for the differential effects of high carbohydrate diets on lipogenesis in rat liver

1967 • 132 citations

The Synthesis of “Chylomicron-like” Bodies and Maintenance of Normal Blood Sugar Levels by the Isolated, Perfused Rat Liver

1961 • 131 citations

Hepatic lipid metabolism in experimental diabetes

1966 • 130 citations

Metabolism in Vitro of Adipose Tissue in Obese-hyperglycemic and Goldthioglucose-treated Mice

1961 • 129 citations

Role of Hepatic L- -Glycerophosphate and Triglyceride Synthesis in Production of Fatty Liver by Ethanol.

1963 • 129 citations

The influence of epinephrine and fasting on adipose tissue content and release of free fatty acids in obese-hyperglycemic and lean mice

1960 • 127 citations

Insulin: Inducer of Pyruvate Kinase

1965 • 126 citations

Measurements of insulin activities in pancreas and serum of mice with spontaneous (?obese? and ?New Zealand obese?) and induced (goldthioglucose) obesity and hyperglycemia, with considerations on the pathogenesis of the spontaneous syndrome

1967 • 125 citations

Syndrome of Idiopathic Hyperlipemia, Mild Diabetes Mellitus, and Severe Vascular Damage

1955 • 123 citations

Incorporation of malonyl CoA into fatty acids by liver in starvation and alloxan-diabetes

1960 • 122 citations

Plasma Triglyceride Concentration and Plasma Free Fatty Acid Changes in Response to Norepinephrine in Man*

1964 • 119 citations

Studies on the Relationship Between Glucose Oxidation and Intermediary Metabolism. II. The Role of Glucose Oxidation in Lipogenesis in Diabetic Rat Liver12

1958 • 119 citations

THE RÔLE OF INSULIN IN CARBOHYDRATE METABOLISM

1940 • 116 citations

Clearing-factor lipase in adipose tissue. A medium in which the enzyme activity of tissue from starved rats increases in vitro

1966 • 116 citations

Relationship of Hepatic Uptake of Free Fatty Acids to Plasma Concentration.

1960 • 115 citations

Effects of Carbohydrate Feeding on Serum Lipids and Lipoproteins in the Rat

1957 • 115 citations

Relationship of lipoprotein lipase activity to triglyceride uptake in adipose tissue

1967 • 114 citations

Early effects of ‘total’ pancreatectomy on fat metabolism in the rat

1958 • 114 citations

Effect of dietary sucrose and starch on oral glucose tolerance and insulin-like activity

1964 • 113 citations

Citrate Cleavage Enzyme in Livers of Obese and Nonobese Mice

1964 • 113 citations

Dietary Fats, Carbohydrates and Atherosclerotic Vascular Disease

1967 • 111 citations

Studies on Carbohydrate Metabolism in Rat Liver Slices

1958 • 110 citations

Comparative turnover rates of free fatty acids and glycerol in blood of dogs under various conditions

1963 • 110 citations

Acute Insulin Withdrawal and the Regulation of Plasma Triglyceride Removal in Diabetic Subjects

1968 • 110 citations

Effects of Epinephrine on Lipid Partition and Metabolism in the Rabbit

1957 • 110 citations

Distribution of C¹⁴ in Rats after Intravenous Injection of Non‐Esterified Palmitic Acid‐1‐C¹⁴.

1959 • 108 citations

An approach to the question, does all diabetes depend upon a single genetic locus?

1962 • 108 citations

Lipid Metabolism

1964 • 107 citations

Plasma free fatty acid turnover during insulin-induced hypoglycemia

1961 • 107 citations

Effect of insulin on release of plasma lipolytic activity and clearing of emulsified fat intravenously administered to pancreatectomized and alloxanized dogs.

1962 • 106 citations

Carbohydrate Intolerance and Lipemia

1968 • 106 citations

The relative amounts of long-chain acylcarnitine, acetylcarnitine, and free carnitine in organs of rats in different nutritional states and with alloxan diabetes

1966 • 104 citations

INSULIN AND HEPATIC UTILIZATION OF GLUCOSE FOR LIPOGENESIS

1950 • 101 citations

Effect of weight reduction and caloric balance on serum lipoprotein and cholesterol levels

1953 • 101 citations

Fat Metabolism in Three Forms of Experimental Obesity

1955 • 101 citations

Some hormonal effects on uptake of free fatty acids by the liver

1960 • 100 citations

Time of occurrence of changes in the liver's capacity to utilize acetate for fatty acid and cholesterol synthesis after fat feeding

1960 • 100 citations

SPLANCHNIC PRODUCTION AND UPTAKE OF ENDOGENOUS TRIGLYCERIDES IN THE FASTING STATE IN MAN*

1963 • 99 citations

Some aspects of lipid metabolism in rats treated with anti-insulin serum

1962 • 99 citations

Heterogeneity in the rate of plasma clearance of chylomicrons of different size

1966 • 98 citations

Studies in the Ketosis of Fasting*

1967 • 97 citations

Citrate content of liver and kidney of rat in various metabolic states and in fluoroacetate poisoning

1967 • 96 citations

EFFECT OF FRUCTOSE ON LIPOGENESIS FROM LACTATE AND ACETATE IN DIABETIC LIVER

1952 • 96 citations

CITRATE AND THE CONVERSION OF CARBOHYDATE INTO FAT. ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF NORMAL AND DIABETIC RATS

1965 • 95 citations

Lipogenesis and Carbohydrate Utilization: Effects of Glucose Concentration and Insulin in Rat Liver and Adipose Tissue

1956 • 95 citations

Adipokinetic Activity of Porcine Fraction H in the Rabbit—Guinea Pig—Rat and Mouse

1962 • 95 citations

ON THE MANNER OF TRANSPORT OF ABSORBED FRUCTOSE

1957 • 94 citations

Changes in Serum Lipid Levels of Hyperlipemic Patients Following the Feeding of Starch, Sucrose and Glucose

1966 • 94 citations

Quantitative Determination of the Glucoprotein Pattern of Normal Serum After Electrophoretic Separation on Filter Paper

1956 • 94 citations

Citrate and the conversion of carbohydrate into fat. A comparison of citrate and acetate incorporation into fatty acids

1964 • 94 citations

The effect of insulin on concentration of plasma glycerol

1963 • 94 citations

Fatty Acid Synthesis from Acetate by Normal and Diabetic Rat Liver Homogenate Fractions

1960 • 92 citations

On the conversion of fructose to glucose by guinea pig intestine

1960 • 91 citations

STUDIES ON CARBOHYDRATE METABOLISM IN RAT LIVER SLICES

1954 • 91 citations

X. Endogenous dilution of administered labeled acetate during lipogenesis and cholesterogenesis in two types of obese mice

1959 • 90 citations

Observations on the Peripheral Metabolism of Nonesterified Fatty Acids

1959 • 90 citations

Metabolism of chylomicrons and triglyceride emulsions by perfused rat adipose tissue

1965 • 90 citations

Release of Non-Esterified Fatty Acids from Adipose Tissue in Normal and Diabetic Rats

1959 • 88 citations

THE EFFECT OF INSULIN ON LIPOLYSIS.

1964 • 87 citations

Carbohydrate Intolerance and Hyperlipemia in Patients with Myocardial Infarction Without Known Diabetes Mellitus

1963 • 86 citations

Dynamics of plasma triglyceride turnover in man

1965 • 86 citations

EFFECT OF SIMPLE AND COMPLEX CARBOHYDRATES ON PLASMA NON-ESTERIFIED FATTY ACIDS, PLASMA-SUGAR, AND PLASMA-INSULIN DURING ORAL CARBOHYDRATE TOLERANCE TESTS

1966 • 85 citations

THE EFFECT OF PYRUVATE AND INSULIN ON FATTY ACID SYNTHESIS IN VITRO

1948 • 84 citations

Effect of Dietary Carbohydrate on Experimentally Induced Hypercholesteremia and Hyperbetalipoproteinemia in Rats.

1956 • 83 citations

THE EFFECT OF INCUBATION ON THE CHARACTERISTICS OF THE LIPOLYTIC ACTIVITY OF RAT ADIPOSE TISSUE

1962 • 82 citations

In Vitro Studies on the Glucose Uptake and Fatty Acid Metabolism of Human Adipose Tissue in Diabetes Mellitus¹

1963 • 82 citations

Turnover of Palmitate C-14 in Diabetics and Normals.

1963 • 81 citations

Blood and Tissue Changes in the Dog during and after Excessive Free Fatty Acid Mobilization

1965 • 81 citations

Glucose, Sucrose and Lactose in the Diet and Blood Lipids in Man

1963 • 80 citations

THE EFFECTS OF INSULIN, GLUCAGON AND ADRENOCORTICOTROPHIC HORMONE ON THE PLASMA GLUCOSE AND FREE FATTY ACIDS OF THE DOMESTIC FOWL

1965 • 80 citations

Citrate Cleavage Enzyme and Fatty Acid Synthesis

1968 • 80 citations

INSULIN: SUPPRESSOR OF BIOSYNTHESIS OF HEPATIC GLUOCNEOGENIC ENZYMES

1965 • 79 citations

Induction of hyperglyceridemia by fructose in the rat

1965 • 79 citations

Effects of diet on hepatic triglyceride synthesis

1968 • 79 citations

SOME INFLUENCES OF THE SYMPATHETIC NERVOUS SYSTEM AND INSULIN ON MOBILIZATION OF FAT FROM ADIPOSE TISSUE: STUDIES OF THE TURNOVER RATES OF FREE FATTY ACIDS AND GLYCEROL*

1965 • 76 citations

Some hormonal influences on the hepatic uptake of free fatty acids in diabetic dogs.

1962 • 76 citations

Dietary response of various key enzymes related to glucose metabolism in normal and diabetic rat liver

1967 • 74 citations

The Lipid Response of Young Women to Dietary Carbohydrates

1965 • 73 citations

The Relation of Insulin to Liver Metabolism

1956 • 72 citations

Insulin: Inducer of glucose 6-phosphate dehydrogenase

1966 • 71 citations

Absorption of Fructose in Man

1965 • 70 citations

Treatment of Hypertriglyceridemia

1966 • 69 citations

Relationship between Free Fatty Acid Turnover and Total Body Oxygen Consumption in the Euthyroid and Hyperthyroid States*

1965 • 69 citations

NUTRITIONAL FACTORS IN FATTY ACID SYNTHESIS BY TISSUE SLICES IN VITRO

1952 • 69 citations

FATTY-ACID COMPOSITION OF LIPID FRACTIONS IN DIABETIC SERUM

1963 • 69 citations

Influence of Previous Diet on Hepatic Glycogenesis and Lipogenesis

1955 • 68 citations

Insulin Action in Alloxan Diabetes Modified by Actinomycin D

1964 • 68 citations

The effect of a low fat diet on the serum lipids in diabetes and its significance in diabetic retinopathy

1959 • 67 citations

Tissue levels of activated fatty acids (acylcarnitines) and the regulation of fatty acid metabolism

1967 • 67 citations

Lack of Uptake and Oxidation of Chylomicron Triglyceride to Carbon Dioxide and Ketone Bodies by the Perfused Rat Liver

1965 • 66 citations

Hyperlipemia and Diabetes Mellitus

1966 • 65 citations

THE EFFECT OF THE TYPE AND AMOUNT OF DIETARY FAT ON THE LEVEL OF PLASMA TRIGLYCERIDES IN HUMAN SUBJECTS IN THE POSTABSORPTIVE STATE

1964 • 65 citations

INSULIN AND THE FATE OF LACTATE IN THE DIABETIC LIVER

1951 • 64 citations

Regulatory Pattern of Liver Carbohydrate Metabolizing Enzymes: Insulin as Inducer of Key Glycolytic Enzymes

1966 • 64 citations

THE PHYSIOLOGY OF THE LIVER

1931 • 64 citations

Studies on lipogenesis in vivo: Fatty acid and cholesterol synthesis in hyperglycaemic-obese mice

1967 • 64 citations

Acute insulin deficiency provoked by single injections of anti‐insulin serum

1960 • 63 citations

Quantitative aspects of free fatty acid metabolism in the fasted rat

1967 • 63 citations

Effect of glucose load and of insulin on the metabolism of glucose and of palmitate in sheep

1967 • 57 citations

Influence of dietary factors upon human serum lipoprotein concentrations.

1957 • 57 citations

CIRCULATING LIPIDS IN DIABETES MELLITUS

1959 • 57 citations

Hepatic lipid metabolism in experimental diabetes. II. Incorporation of [I-14C]palmitate into lipids of the liver and of the d less than 1.020 perfusate lipoproteins.

1967 • 57 citations

ALTERED METABOLIC PATTERNS INDUCED IN THE NORMAL RAT BY FEEDING AN ADEQUATE DIET CONTAINING FRUCTOSE AS SOLE CARBOHYDRATE

1954 • 57 citations

Acute Effects of Nicotinic Acid in the Rat

1966 • 57 citations

THE RAPIDITY WITH WHICH ALCOHOL AND SOME SUGARS MAY SERVE AS NUTRIMENT

1916 • 57 citations

Alloxan Diabetes and Demonstrated Direct Action of Insulin on Metabolism of Isolated Perfused Rat Liver

1957 • 56 citations

Induction of adipose tissue lipoprotein lipase by nicotinic acid

1968 • 56 citations

Umsatzraten für freie Fettsäuren und Triglyceride im Plasma bei essentieller Hyperlipämie

1966 • 56 citations

Response of Blood Glucose and Plasma Free Fatty Acids to Fasting and to Injection of Insulin and Testosterone in Chickens

1967 • 54 citations

Dietary Carbohydrates in Hyperlipemia (Hyperglyceridemia); Hepatic and Adipose Tissue Lipogenic Activities

1967 • 54 citations

The Effect of Glycerol 3-Phosphate on Fatty Acid Synthesis

1965 • 54 citations

LIPEMIA

1921 • 53 citations

Insulin resistance in hyperglyceridemia

1965 • 53 citations

Directions and patterns of adaptation induced in liver enzymes of the diabetic rat by the feeding of glucose and fructose

1962 • 51 citations

Citrate and the conversion of carbohydrate into fat. The regulation of fatty acid synthesis by rat liver extracts

1967 • 50 citations

Lipoprotein lipase activity in human adipose tissue I. Conditions for release and relationship to triglycerides in serum

1966 • 50 citations

Hepatic triglyceride secretion in relation to lipogenesis and free fatty acid mobilization in fasted and glucose-refed rats

1968 • 50 citations

Free fatty acids as lipogenic inhibitors

1964 • 49 citations

Dietary control of liver glucokinase activity in the normal rat

1964 • 49 citations

Acute effects of fructose and glucose on the concentration and removal rate of plasma triglyceride

1966 • 47 citations

Effect of Dietary Carbohydrate on Hepatic Lipogenesis in the Rat

1968 • 46 citations

Studies on the Perfused Rat Liver: I. Effects of Glucagon and Insulin on Glucose Metabolism

1966 • 46 citations

LIPOIDS OF SERUM IN DIABETIC ACIDOSIS

1934 • 46 citations

Effect of Insulin Pretreatment on Glucose and Lipid Metabolism of Liver Slices from Normal Rats.

1966 • 45 citations

Studies of carbohydrate metabolism in idiopathic hypertriglyceridemia

1965 • 45 citations

Hepatic lipid metabolism in experimental diabetes

1967 • 45 citations

Effects of prolonged ingestion of glucose or ethanol on tissue lipid composition and lipid biosynthesis in rat

1966 • 45 citations

The effects of various dietary carbohydrates on the serum lipids during a five-day regimen.

1965 • 45 citations

Interrelation of Actions of Glucose, Insulin, and Glucagon on Induction of Adenosine Triphosphate:d-Hexose Phosphotransferase in Rat Liver

1966 • 44 citations

STUDIES IN CARBOHYDRATE METABOLISM

1946 • 43 citations

Studies in Vitro on Fatty Acid Metabolism of Human Subcutaneous Adipose Tissue in Diabetes Mellitus¹

1965 • 43 citations

THE INTERMEDIARY METABOLISM OF FRUCTOSE AND GALACTOSE

1936 • 42 citations

Regulation of adipose tissue lipoprotein lipase synthesis by intracellular free fatty acid

1968 • 42 citations

SERUM LIPOIDS IN DIABETES

1935 • 42 citations

Effect of diabetes and starvation on myocardial triglyceride and free fatty acid utilization

1966 • 42 citations

Insulin: Inducer of phosphofructokinase

1965 • 42 citations

Triglyceride turnover in coronary heart disease and the effect of dietary carbohydrate.

1966 • 41 citations

The metabolism of free fatty acids and chylomicron triglycerides by the isolated perfused liver of the rat

1963 • 41 citations

Relation between Glycogen Content and Synthesis of Fatty Acids by Rat Liver

1952 • 41 citations

Effects of insulin on glucose metabolism by the perfused normal rat liver

1967 • 40 citations

Liver Glucokinase Induction in Acute and Chronic Insulin Insufficiency in Rats

1967 • 40 citations

INSULIN RESPONSE TO FRUCTOSE AND GALACTOSE

1963 • 40 citations

Fatty acid adsorption by liver- and adipose-tissue particles

1965 • 40 citations

Zur natur der antiketogenen wirkung von glycerin und fructose

1962 • 39 citations

Fatty acid synthesis from glucose-1-H³ and glucose-1-C¹⁴ in obese-hyperglycemic mice

1964 • 39 citations

Effect of glucose, fructose, sucrose and starch on lipgenesis in rats

1968 • 39 citations

Influence of Various Carbohydrates on the Utilization of Low Protein Rations by the White Rat II. Comparison of Several Proteins and Carbohydrates. Growth and Liver Fat

1953 • 39 citations

PARALLEL RELATION OF HYPERGLYCEMIA AND HYPERLIPEMIA (ESTERIFIED FATTY ACIDS) IN DIABETES

1953 • 39 citations

Relationship between FFA flux and TGFA influx in plasma before and during the infusion of insulin

1967 • 38 citations

The role of the liver in the uptake of plasma and chyle triglycerides in the rat

1966 • 38 citations

Glycolytic Pathways: Their Relation to the Synthesis of Cholesterol and Fatty Acids

1958 • 38 citations

Der Einflu� von Insulin auf die enzymatische Regulation der Glycogenolyse

1966 • 38 citations

The Metabolism of Intraportally Injected Fructose in Rat Liver in Vivo

1962 • 37 citations

Blood Lipids in Diabetic and Non‐Diabetic Schoolchildren

1963 • 37 citations

INSULIN AND THE FATE OF ACETATE AND FORMATE IN THE DIABETIC LIVER

1951 • 37 citations

Hepatic glycolytic and gluconeogenic enzymes of the obese-hyperglycemic mouse

1967 • 37 citations

NATURE OF THE STIMULATING ACTION OF INSULIN ON LIPOGENESIS FROM ACETATE IN FASTED RAT LIVER

1952 • 36 citations

Endogenous triglyceride turnover in liver and plasma of the dog

1967 • 35 citations

Studies on the Control of Fatty Acid Synthesis

1967 • 35 citations

Effects of insulin on triglyceride and free fatty acid metabolism in man

1965 • 34 citations

Glucose repression and induction of enzyme synthesis in rat liver

1964 • 34 citations

Studies of the Metabolic Effects of Acute Insulin Deficiency: II. Changes in Hepatic Glycolytic and Krebs-Cycle Intermediates and Pyridine Nucleotides

1966 • 33 citations

STUDIES IN CARBOHYDRATE METABOLISM

1945 • 33 citations

Studies in Experimental Diabetes

1964 • 32 citations

The relation of hepatic α-glycerophosphate concentration to lipogenesis in rat liver

1967 • 32 citations

Overweight and triglyceride level in normal persons and patients with diabetes mellitus

1966 • 32 citations

Effect of Insulin in Hypertriglyceridemia

1965 • 31 citations

Portal venous injection of insulin in the diabetic rat: time of induction of changes in hepatic lipogenesis, cholesterogenesis, and glycogenesis

1960 • 31 citations

Lack of uptake and metabolism of the triglyceride of serum lipoproteins of density less than 1.006 by the perfused rat liver

1967 • 30 citations

INSULIN AND THE FATE OF PYRUVATE IN THE DIABETIC LIVER

1951 • 30 citations

Hepatic Lipid Metabolism in Experimental Diabetes

1968 • 29 citations

Studies of the Metabolic Effects of Acute Insulin Deficiency: I. Mechanism of Impairment of Hepatic Fatty Acid and Protein Synthesis

1966 • 28 citations

The synergistic effect of cortisone and insulin on lipogenesis in the perfused rat liver as studied with α-C14-acetate

1951 • 28 citations

Effect of Insulin on Clearance of Emulsified Fat from the Blood in Depancreatized Dogs.

1957 • 28 citations

Mechanism of Digitalis Action on the Heart

1967 • 28 citations

An enzymic defect in fatty acid synthesis by alloxan-diabetic rat liver

1960 • 27 citations

Some aspects of glucose metabolism in normal and alloxan-diabetic rats

1962 • 27 citations

Effect of carbohydrate ingestion on postprandial lipemia

1957 • 27 citations

Hepatic lipid metabolism in experimental diabetes: III. Synthesis and utilization of triglycerides

1967 • 26 citations

Metabolism of chylomicrons by the isolated rat liver

1967 • 26 citations

Fructose Metabolism

1968 • 26 citations

Coenzym A-Thioester höherer Fettsäuren als mögliche Vermittler enzymatischer Regulationen im Tierkörper

1965 • 26 citations

THE BLOOD LIPIDS OF DIABETIC CHILDREN 1

1936 • 26 citations

Adaptive changes in alpha-glycerophosphate-generating enzymes in rat liver

1968 • 25 citations

Carbohydrate-induced hypertriglyceridemia and glucose utilization in ischemic heart disease

1966 • 25 citations

Plasmalipide bei Patienten mit Diabetes mellitus

1966 • 25 citations

Triglyceride Metabolism in the Alloxan-Diabetic Rat

1967 • 25 citations

Incorporation of lipoprotein-borne triglycerides by adipose tissue in vitro

1965 • 25 citations

Lipoprotein Lipase Activity in Patients with Diabetes Mellitus, with and without Hyperlipemia

1966 • 25 citations

The Effect of Glucose Availability and Utilization on Chylomicron Metabolism in the Rat

1966 • 25 citations

Serum lipids in different phases of carbohydrate metabolism.

1956 • 25 citations

Influence of diet on utilization of glucose and incorporation of acetate-I-C¹⁴ into liver fatty acids and cholesterol in rats

1959 • 25 citations

Lipoprotein Lipase in Fat-Induced Hyperlipemia

1968 • 24 citations

Metabolic Effects of Nicotinic Acid in Acute Insulin Deficiency in the Rat

1968 • 24 citations

Hyperglyceridemia induced by glycerol feeding

1964 • 24 citations

Synthesis in Vitro of Glyceride-Glycerol by the Liver of Normal and Pancreatectomized Rats

1964 • 23 citations

The relation of lipogenesis to reduced triphosphopyridine nucleotide generation and to certain enzyme activities in the liver of the “totally” depancreatized rat

1962 • 23 citations

Steuerung der endogenen Lipoproteid-Lipase-Aktivität im Plasma bei Normalpersonen und Patienten mit essentieller Hyperlipämie

1965 • 23 citations

ALTERATIONS IN TRIGLYCERIDE METABOLISM AS PRODUCED BY DIETARY CHANGE.

1964 • 23 citations

Effects of insulin and diabetes on flux rates of plasma glucose and free fatty acids

1966 • 23 citations

THE EFFECT OF FASTING ON ESTERIFICATION OF PALMITATE BY RAT LIVER IN VITRO

1966 • 22 citations

Studies of the Metabolism of Isolated Livers of Normal and Alloxan-diabetic Rats Perfused with Insulin

1968 • 22 citations

The antiketogenic action of sorbitol

1964 • 22 citations

Effect of fast and hexose injection on serum insulin concentrations of sheep

1964 • 22 citations

TRANSFERS OF CARBON‐14 AND TRITIUM FROM SUBSTRATES TO CO₂, WATER, AND LIPIDS IN OBESE AND DIABETIC SUBJECTS IN VIVO

1965 • 22 citations

Influence of Carbohydrate, Nitrogen Source and Prior State of Nutrition on Nitrogen Balance and Liver Composition in the Adult Rat

1954 • 22 citations

Inhibition of the Mobilization of Free Fatty Acids from Adipose Tissue in Diabetes

1965 • 22 citations

EFFECTS OF ALIPHATIC ALCOHOLS ON THE METABOLISM OF GLUCOSE AND FRUCTOSE IN RAT LIVER SLICES

1963 • 22 citations

Some factors affecting the metabolism of free fatty acids and chylomicron triglycerides by the perfused rat's liver

1963 • 22 citations

The effect of insulin on the metabolism of lipids and on urea formation by the perfused rat liver

1968 • 21 citations

Studies on Diabetic Lipemia. I

1926 • 20 citations

Urinary excretion of phenethylamine and tyramine in normal subjects and heterozygous carriers of phenylketonuria

1964 • 20 citations

The Effect of Insulin in Vitro on Human Adipose Tissue from Normal and Diabetic Subjects

1967 • 20 citations

I131 Triolein Tolerance Curves in Patients with Diabetes Mellitus

1960 • 20 citations

Die Wirkung von Insulin auf den Stoffwechsel der isolierten perfundierten Leber normaler und alloxandiabetischer Ratten

1966 • 20 citations

STUDIES ON FAT METABOLISM II. THE EFFECT OF CERTAIN HORMONES ON FAT TRANSPORT*

1930 • 19 citations

Insulin preservation of glucokinase activity in isolated perfused rat liver

1967 • 19 citations

Blood Lipid and Protein Levels in Juvenile Diabetes Mellitus

1960 • 19 citations

Effect of Sex, Fasting and Alloxan Diabetes on the Uptake of Neutral Fat by Isolated Perfused Rat Liver

1958 • 19 citations

Ketone formation and inhibition of liver lipid synthesis by chylomicrons

1963 • 19 citations

Substitution of Dietary Starch for Dextrose in Hyperlipemic Subjects.

1966 • 19 citations

The Rate of Generation of Reduced Nicotinamide Adenine Dinucleotide and Reduced Nicotinamide Adenine Dinucleotide Phosphate in the Liver of Normal and Alloxan Diabetic Rats

1963 • 19 citations

Sequential Changes in Adipose Tissue Metabolism in Alloxan-Diabetic Rats

1965 • 18 citations

Clearing factor, fibrinolysis and blood lipids in diabetes mellitus.

1962 • 18 citations

Heparin-induced Lipemia Clearing Factor in Rats: Role of the Pancreas in its Production

1959 • 18 citations

Le métabolisme lipidique du foie chez la souris normale et la souris obèse-hyperglycémique

1968 • 17 citations

THE RELATION BETWEEN INGESTED FAT AND THE LIPEMIA OF DIABETES MELLITUS

1923 • 17 citations

Insulin effect on glucose-C14 incorporation into rat liver and adipose tissue in vivo

1964 • 17 citations

THE ROLE OF FAT IN DIABETES

1917 • 17 citations

TRIGLYCERIDE TURNOVER AFTER DIETS RICH IN CARBOHYDRATE OR ANIMAL FAT

1965 • 17 citations

Beziehungen zwischen Blutzuckerspiegel, Umsatzrate der freien Fettsäuren und Fettsäureeinbau in Plasmatriglyceride bei Diabetikern

1967 • 16 citations

The serum lipid response of baboons to various carbohydrate meals

1967 • 16 citations

Effects of prolonged ingestion of glucose or ethanol on fatty acid synthesis by mitochondria and cell sap of rat liver and adipose tissue

1966 • 15 citations

SERUM ESTERIFIED FATTY ACIDS WITH FAT TOLERANCE TESTS IN DIABETES MELLITUS

1950 • 15 citations

Modulation of triglyceride kinetics by fructose versus glucose in the rat.

1966 • 15 citations

Untersuchungen über die Post-Heparin-Lipoproteidlipase-Aktivität bei sechs Fällen von essentieller Hyperlipämie

1965 • 14 citations

The effect of insulin and glucose on plasma lipids during pregnancy and the puerperium

1965 • 14 citations

Loss and Repair of Glucose-Disposal Mechanism in Dog Fed Fructose As Sole Dietary Carbohydrate.

1956 • 14 citations

Effects of fructose infusion on glucose uptake and circulating insulin‐like activity in normal men

1961 • 13 citations

Effect of Insulin on Rate of Hepatic Uptake of NEFA.

1960 • 13 citations

CHANGES IN PLASMA TRIGYLCERIDE CONCENTRATION FOLLOWING THE INTRAVENOUS ADMINISTRATION OF GLUCOSE

1964 • 13 citations

EFFECT OF ENHANCED GLUCOSE UTILISATION ON POSTPRANDIAL LIPÆMIA IN ISCHÆEMIC HEART-DISEASE

1964 • 13 citations

Diet and blood lipids in normal and diabetic rats

1965 • 12 citations

THE RELATIONSHIP OF HYPERGLYCAEMIA TO HYPERLIPAEMIA AND KETONAEMIA IN DEPANCREATIZED BABOONS (PAPIO URSINUS)

1958 • 12 citations

Defective Synthesis of Triglyceride Fatty Acids from l-C-14 Acetate in the Well-controlled Stable Adult Diabetic

1961 • 11 citations

Hyperlipämie und latenter Diabetes mellitus

1965 • 11 citations

Effect of Anti-Insulin Serum on Hepatic Metabolism

1962 • 11 citations

Über den Einfluß der Glucose auf den Umsatz der freien Fettsäuren des Plasmas, die Einbaurate der freien Fettsäuren in Plasmatriglyceride und die Wirkung von Noradrenalin auf diese Stoffwechselgrößen beim Menschen

1967 • 10 citations

The effect of insulin on the uptake of radioactive labelled plasma triglycerides by rat tissue in vivo

1967 • 10 citations

The Tissue Distribution and Metabolism in the Rat of Intravenously Injected Labeled Fat Emulsions

1964 • 10 citations

Effect of Dextran Sulfate on Plasma Lipoprotein Lipase Activity in Obese Subjects and Diabetic Patients

1967 • 10 citations

Determination of Liver L-alpha-Glycerophosphate.

1963 • 10 citations

Heparin-activated lipase in diabetic, atherosclerotic and healthy subjects

1967 • 10 citations

Effect of variations in previous diet on fasting plasma lipids.

1963 • 9 citations

Hormonal Effects on C-14 Acetate Metabolism in the Human.

1959 • 9 citations

Effect of fructose feeding on glucose tolerance in man.

1957 • 9 citations

Effects of Fat Mobilization on Liver Acetate Metabolism

1966 • 9 citations

Effects of Insulin on Metabolism of Perfused Livers of Rats Made Acutely Diabetic by Anti-insulin Serum Injection

1968 • 9 citations

LIPID METABOLISM IN EXPERIMENTAL PANCREATIC DIABETES I. BLOOD AND LIVER LIPIDS OF DOGS FASTED DURING TOTAL INSULIN DEPRIVATION¹

1941 • 9 citations

Serum Lipids in Diabetic and Nondiabetic Rats: Effect of Varying Lipid Diets

1956 • 9 citations

Einfluß von Insulin auf Kohlenhydrat- und Fettstoffwechsel der perfundierten Leber bei normalen und Alloxan-diabetischen Ratten

1966 • 8 citations

Serum Lipids and Glucose Tolerance in Subjects with a Family History of Diabetes Mellitus

1965 • 8 citations

Plasma free fatty acid appearance in plasma triglycerides

1967 • 8 citations

Die Verwendung von Plasmaglucose-Kohlenstoff zur Bildung von Plasmatriglycerid-Glycerol bei Patienten mit primärer „kohlenhydratinduzierter“ Hypertriglyceridämie

1968 • 6 citations

Incorporation of Tritium into Human Plasma Triglycerides from Glucose-1-3H and Lactic Acid-2-3H

1964 • 6 citations

Fatty Acid Synthesis by Surviving Hepatic Tissue of “Acute” and “Chronic” Diabetic Dogs1

1964 • 5 citations

Effect of insulin in a case of essential hyperlipemia

1959 • 4 citations

Effects of acute insulin insufficiency on liver and adipose tissue fatty acid synthesis

1965 • 4 citations

EFFECT OF TOLBUTAMIDE IN CLEARING INDUCED ALIMENTARY LIPÆMIA AFTER ALCOHOLIC HEPATOPANCREATIC DAMAGE

1964 • 3 citations

Inverse relationship between adipose tissue and skeletal muscle in the uptake of injected triglyceride fatty acid of chyle lipoproteins by diabetic rats

1967 • 3 citations

Effect of Hypophyseal Growth Hormone in Adult Rats on a Potassium-Deficient Diet

1962 • 2 citations

Beitrag zur Beleuchtung der alimentären Lipämie des Menschen¹

1931 • 2 citations

Clinical Study on Lipid Metabolism Effect of Glucose and Insulin on Nefa Metabolism

1965 • 1 citations

The effect of pancreatectomy on fatty acid synthesis in liver of fasted rats

1965 • 1 citations

Influence of Prolonged Carbon Monoxide Exposure and High Altitude on the Composition of Blood and Urine in Man

1968 • 1 citations