Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Advances in prostaglandin and thromboxane research

1976 • 602 citations

Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat

1981 • 447 citations

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa

1980 • 401 citations

Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.

1976 • 330 citations

Effect of Prostaglandin E1 on Gastric Secretion and Ulcer Formation in the Rat

1968 • 285 citations

MECHANISMS UNDERLYING GASTRIC MUCOSAL DAMAGE INDUCED BY INDOMETHACIN AND BILE‐SALTS, AND THE ACTIONS OF PROSTAGLANDINS

1977 • 272 citations

Role of prostaglandins in the formation of aspirin-induced gastric ulcers

1981 • 218 citations

Fecal Blood Loss Produced by Oral and Intravenous Administration of Various Salicylates

1961 • 213 citations

Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates

1978 • 154 citations

Role of Gastric Acid in Aspirin-Induced Gastric Irritation in the Rat

1967 • 153 citations

Radioimmunological assay of prostaglandin synthetase activity

1973 • 149 citations

Effects of route of administration on the production of gastric hemorrhage in the rat by aspirin and sodium salicylate

1971 • 43 citations

Comparison of Intravenous and Intragastric Aspirin in Production of Antral Gastric Ulcers in Cats

1980 • 25 citations