Host Cell Protection from Complement by Glycosyl-phosphatidylinositol-Anchored Complement Inhibitors and Their Deficiencies in Paroxysmal Nocturnal Hemoglobinuria

CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

1988 • 1,284 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

1982 • 603 citations

Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes.

1984 • 571 citations

Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

1983 • 438 citations

Distribution of decay-accelerating factor in the peripheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria.

1985 • 408 citations

Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria.

1989 • 407 citations

The Pi-linked receptor FcRIII is released on stimulation of neutrophils

1988 • 402 citations

The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

1988 • 387 citations

Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins

1987 • 359 citations

Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein.

1986 • 358 citations

Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.

1987 • 340 citations

Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria.

1983 • 324 citations

Structure-function relationships of the complement components

1989 • 311 citations

Paroxysmal Nocturnal Hemoglobinuria: Evidence for Monoclonal Origin of Abnormal Red Cells

1970 • 289 citations

Decay accelerating factor of complement is anchored to cells by a C-terminal glycolipid

1986 • 282 citations

Glycosyl‐phosphatidylinositol: a versatile anchor for cell surface proteins ¹

1989 • 267 citations

Isolation from Human Erythrocytes of a New Membrane Protein Which Inhibits the Formation of Complement Transmembrane Channels1

1988 • 266 citations

Monocyte antigen CD14 is a phospholipid anchored membrane protein

1989 • 257 citations

Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.

1987 • 256 citations

Homologous species restriction in lysis of human erythrocytes: a membrane-derived protein with C8-binding capacity functions as an inhibitor.

1986 • 241 citations

Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels.

1986 • 240 citations

The mechanism of action of decay-accelerating factor (DAF). DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb.

1987 • 205 citations

A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement

1989 • 203 citations

Deficiency of the homologous restriction factor in paroxysmal nocturnal hemoglobinuria.

1987 • 167 citations

Deficiency of the Complement Regulatory Protein, Decay-Accelerating Factor, on Membranes of Granulocytes, Monocytes, and Platelets in Paroxysmal Nocturnal Hemoglobinuria

1985 • 153 citations

Identification of human erythrocyte blood group antigens on decay- accelerating factor (DAF) and an erythrocyte phenotype negative for daf

1988 • 146 citations

Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system

1985 • 143 citations

Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositol

1989 • 135 citations

Decay-accelerating factor is present on cultured human umbilical vein endothelial cells.

1986 • 129 citations

Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.

1987 • 128 citations

Paroxysmal nocturnal haemoglobinuria

1992 • 117 citations

Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor.

1985 • 117 citations

Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9.

1987 • 113 citations

Paroxysmal Nocturnal Haemoglobinuria

1985 • 98 citations

Biochemical studies on leucocytes. II. Phosphatase activity in chronic lymphatic leucemia, acute leucemia, and miscellaneous hematologic conditions.

1951 • 97 citations

Relationship between decay accelerating factor deficiency, diminished acetylcholinesterase activity, and defective terminal complement pathway restriction in paroxysmal nocturnal hemoglobinuria erythrocytes.

1987 • 83 citations

Endogenous association of decay-accelerating factor (DAF) with C4b and C3b on cell membranes.

1986 • 82 citations

Neutrophil (Leucocyte) Alkaline Phosphatase in Paroxysmal Nocturnal Haemoglobinuria

1965 • 79 citations

A human cell-surface glycoprotein that carries Cromer-related blood group antigens on erythrocytes and is also expressed on leucocytes and platelets.

1987 • 75 citations

Decay accelerating factor regulates complement activation on glomerular epithelial cells.

1989 • 67 citations

Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

1988 • 62 citations

Erythrocyte Acetylcholinesterase Deficiency in Paroxysmal Nocturnal Hemoglobinuria (PNH)—A Comparison of the Complement-Sensitive and Insensitive Populations

1969 • 57 citations

Decay-accelerating factor is present on paroxysmal nocturnal hemoglobinuria erythroid progenitors and lost during erythropoiesis in vitro.

1985 • 53 citations

Paroxysmal nocturnal hemoglobinuria. Enhanced stimulation of platelets by the terminal complement components is related to the lack of C8bp in the membrane.

1988 • 44 citations

The Molecular Basis of Target Cell Killing by Human Lymphocytes and of Killer Cell Self‐Protection

1988 • 40 citations

The C8-binding protein of human erythrocytes: interaction with the components of the complement-attack phase.

1988 • 37 citations

Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

1988 • 37 citations

Different distribution of decay-accelerating factor on hematopoietic progenitors from normal individuals and patients with paroxysmal nocturnal hemoglobinuria

1988 • 29 citations

Different distribution of decay-accelerating factor on hematopoietic progenitors from normal individuals and patients with paroxysmal nocturnal hemoglobinuria

1988 • 25 citations

Decay‐accelerating factor (DAF) on the blood cell membranes in patients with paroxysmal nocturnal haemoglobinuria (PNH): measurement by enzyme‐linked immunosorbent assay (ELISA)

1988 • 24 citations

A high m.w. form of decay-accelerating factor (DAF-2) exhibits size abnormalities in paroxysmal nocturnal hemoglobinuria erythrocytes.

1987 • 24 citations

Not all in a name

1989 • 22 citations

Induction of expression of cell-surface homologous restriction factor upon anti-CD3 stimulation of human peripheral lymphocytes.

1988 • 20 citations

Molecular Mechanisms of Cytotoxicity: Comparison of Complement and Killer Lymphocytes

1986 • 7 citations