Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1982 • 160 citations

Haloperidol Disposition Is Dependent on Debrisoquine Hydroxylation Phenotype

1992 • 157 citations

D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate

1995 • 148 citations

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism

1993 • 146 citations

PCR-based genotyping for duplicated and deleted CYP2D6 genes

1996 • 110 citations

Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol.

1997 • 102 citations

Haloperidol Disposition Is Dependent on the Debrisoquine Hydroxylation Phenotype

1992 • 99 citations

Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population

1996 • 98 citations

The Relationship Between Serum Concentration and Therapeutic Effect of Haloperidol in Patients with Acute Schizophrenia

1998 • 86 citations

Haloperidol reductase in human and guinea pig livers.

1989 • 83 citations

Haloperidol and reduced haloperidol plasma levels in selected schizophrenic patients.

1984 • 74 citations

METABOLISM OF HALOPERIDOL

1978 • 73 citations

Effects of the allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia

1999 • 70 citations

Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients

1997 • 69 citations

Haloperidol and Reduced Haloperidol Plasma Levels in Selected Schizophrenic Patients

1984 • 63 citations

ON THE METABOLISM OF HALOPERIDOL IN MAN.

1977 • 56 citations

Characterization of the cytochrome P450 isoenzymes involved in the in vitroN‐dealkylation of haloperidol

1997 • 52 citations

Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia

1994 • 52 citations

Involvement of human cytochrome P450 3A4 in reduced haloperidol oxidation

1998 • 47 citations

Formation of pyridinium species of haloperidol in human liver and brain

1996 • 47 citations

Use of Antisera in the Isolation of Human Specific Conjugates of Haloperidol

1989 • 43 citations

The effect of benztropine on haloperidol-induced dystonia, clinical efficacy and pharmacokinetics: a prospective, double-blind trial.

1991 • 37 citations

Interconversion between haloperidol and reduced haloperidol in healthy volunteers

1989 • 36 citations

Quantification of Reduced Haloperidol and Haloperidol by Radioimmunoassay

1985 • 31 citations

Isolation and Identification of a Metabolite of Haloperidol

1981 • 29 citations

Pronounced Differences in the Disposition of Clomipramine Between Japanese and Swedish Patients

1999 • 28 citations

Haloperidol reduction can be assayed in human red blood cells

1989 • 27 citations

Nonlinear relationship between circulating concentrations of reduced haloperidol and haloperidol: evaluation of possible mechanisms

1994 • 15 citations