EFFECTS OF CISPLATIN ON DNA AND THE POSSIBLE RELATIONSHIPS TO CYTOTOXICITY AND MUTAGENICITY IN MAMMALIAN CELLS

Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode

1965 • 2,890 citations

DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity.

1979 • 402 citations

Inhibitory effects of anti‐tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in vitro

1970 • 372 citations

The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)

1968 • 296 citations

CIS-dichlorodiammineplatinum (II)

1970 • 284 citations

Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test.

1977 • 263 citations

Interactions between mammalian cell DNA and inorganic platinum compounds—I

1974 • 236 citations

DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.

1977 • 200 citations

Modifications of the DNA secondary structure upon platinum binding: a proposed model

1978 • 170 citations

DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.

1978 • 169 citations

Interaction of cis-dichlorodiammineplatinum (II) with DNA

1971 • 157 citations

Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.

1978 • 154 citations

Effect of cis -Platinum(II)Diamminodichloride on Wild Type and Deoxyribonucleic Acid Repair-Deficient Mutants of Escherichia coli

1973 • 137 citations

Increased sensitivity of UV-repair-deficient human cells to DNA bound platinum products which unlike thymine dimers are not recognized by an endonuclease extracted from Micrococcus luteus

1978 • 131 citations

Differentiation of DNA . Platinum Complexes by Fluorescence. The Use of an Intercalating Dye as a Probe

1977 • 123 citations

Kinetics of formation and disappearance of a DNA cross-linking effect in mouse leukemia L1210 cells treated with cis- and trans-diamminedichloroplatinum(II).

1978 • 115 citations

Mutagenicity and toxicity of visible fluorescent light to cultured mammalian cells

1977 • 114 citations

Mutagenicity, cytotoxicity and DNA crosslinking in V79 Chinese hamster cells treated with cis- and trans-Pt(II) diamminedichloride

1979 • 112 citations

The interaction of platinum II compounds with bacteriophages T7 and R17

1972 • 97 citations

Thiourea Reverses Cross-Links and Restores Biological Activity in DNA Treated with Dichlorodiaminoplatinum(II)

1979 • 96 citations

X-ray photoelectron spectroscopy of DNA · Pt complexes Evidence of O6(Gua) · N7(Gua) chelation of DNA with cis-dichlorodiamine platinum(II)

1975 • 94 citations

Carcinogenicity of antitumor cis-platinum(II) coordination complexes in the mouse and rat.

1979 • 94 citations

The induction of lysogenic strains of Escherichia coli by cis-dichlorodiammineplatinum (II)

1971 • 91 citations

DNA-platinum interactions in vitro with trans- and cis- Pt(NH3)2Cl2

1975 • 91 citations

Mutagenic properties of CIS-Platinum(II)diammino-dichloride in Escherichia coli

1975 • 90 citations

Relative efficiencies of a series of square-planar platinum(II) compounds on Salmonella mutagenesis

1977 • 85 citations

Spécificité de l'interaction DNA‐platine dosage du platine, pH métrie

1975 • 81 citations

Template primer inactivation by cis- and trans-dichlorodiammine platinum for human DNA polymerase alpha, beta, and Rauscher murine leukemia virus reverse transcriptase, as a mechanism of cytotoxicity.

1976 • 76 citations

Mutagenic activity of platinum and ruthenium complexes

1975 • 76 citations

Inhibition by caffeine of post-replication repair in Chinese hamster cells treated with cis platinum (II) diamminedichloride: The extent of platinum binding to template DNA in relation to the size of low molecular weight nascent DNA

1976 • 61 citations

Renaturation effects of cis and trans platinum II and IV compounds on calf thymus deoxyribonucleic acid

1975 • 55 citations

Platinum-DNA crosslinking: platinum antitumor drug interactions with native lambda bacteriophage DNA studied using a restriction endonuclease

1978 • 54 citations

Platinum(II) complexes generate frame-shift mutations in test strains of Salmonella typhimurium

1979 • 53 citations

The Chemical and Biological Effects of cis -Dichlorodiammineplatinum (II), an Antitumor Agent, on DNA

1974 • 51 citations

Cytogenetic and mutagenic effects of DDT and DDE in a Chinese hamster cell line

1973 • 46 citations

Cis-Dichlorodiammineplatinum [II]: Inhibition of Nucleic Acid Synthesis in Lymphocytes Stimulated with Phytohemagglutinin

1971 • 43 citations

The interaction of an anti-tumour platinum complex with DNA

1977 • 43 citations

The effect of cis-dichlorodiammineplatinum(II) on Escherichia coli B the role of fil, exr and hcr markers

1973 • 42 citations

Distribution of a platinum anti-tumour drug in HeLa cells by analytical electron microscopy

1978 • 30 citations

Specific biological activity of platinum complexes contribution to the theory of molecular mechanism

1973 • 27 citations

Inactivation of bacteriophages with cis-platinum(ii) diamminedichloride

1975 • 16 citations

Inactivation of papovavirus SV 40 by cis-dichlorodiammine platinum(II).

1972 • 15 citations

The effects of platinum ethylenediamine dichloride on the template activity of DNA

1974 • 11 citations

Differentiation between chelated and non-chelated DNA - Pt complexes by atomic absorption spectrophotometry

1976 • 9 citations