Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

1992 • 1,168 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

1994 • 749 citations

Structure and function of cytochromes P450:a comparative analysis of three crystal structures

1995 • 660 citations

Statistical Intervals: A Guide for Practitioners

1993 • 549 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

1997 • 350 citations

Genetic polymorphism of S-mephenytoin hydroxylation

1989 • 292 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype

1989 • 257 citations

Pharmacokinetics of Citalopram in Relation to the Sparteine and the Mephenytoin Oxidation Polymorphisms

1993 • 214 citations

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.

1998 • 203 citations

Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects

1992 • 179 citations

Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele.

1997 • 178 citations

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1989 • 178 citations

The activation of the biguanide antimalarial proguanil co‐segregates with the mephenytoin oxidation polymorphism‐a panel study.

1991 • 162 citations

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: A population study*

1995 • 156 citations

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1991 • 139 citations

Genetic analysis of the S-mephenytoin polymorphism in a chinese population*

1995 • 135 citations

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians

1998 • 100 citations

A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype

1995 • 95 citations

Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidation polymorphisms

1994 • 92 citations

Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation

1985 • 86 citations

Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity

1996 • 85 citations

The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin*

1997 • 68 citations

Amitriptyline Pharmacokinetics and Clinical Response: II. Metabolic Polymorphism Assessed by Hydroxylation of Debrisoquine and Mephenytoin

1986 • 63 citations

Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography

1984 • 60 citations

Limitation to the use of the urinary S‐/R‐mephenytoin ratio in pharmacogenetic studies.

1991 • 50 citations

Stereoselective disposition of hexobarbital and its metabolites

1994 • 40 citations

Pharmacogenetic association between the formation of 4-hydroxymephenytoin and a new metabolite of S-mephenytoin in man.

1987 • 23 citations

Lung cancer risk in relation to mephenytoin hydroxylation activity

1997 • 12 citations