Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections.

1991 • 2,598 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue.

1992 • 257 citations

p53 expression in colorectal tumors.

1991 • 243 citations

Expression of the nuclear oncogene p53 in colon tumours

1989 • 173 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas.

1991 • 159 citations

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

1991 • 150 citations

Expression of p53 protein in infiltrating and in‐situ breast carcinomas

1991 • 145 citations

TP53 Gene Mutations and 17p Deletions in Human Astrocytomas

1991 • 137 citations

Occurrence of p53 Gene Abnormalities in Gastric Carcinoma Tumors and Cells Lines

1991 • 131 citations

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma

1992 • 94 citations

Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

1991 • 78 citations