Approaches to Quantitative Analysis of Amino Acid Transport and Metabolism

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1971 • 1,671 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Amino acid assignment to one of three blood-brain barrier amino acid carriers

1976 • 593 citations

Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier

1987 • 441 citations

KINETICS OF COMPETITIVE INHIBITION OF NEUTRAL AMINO ACID TRANSPORT ACROSS THE BLOOD‐BRAIN BARRIER

1977 • 357 citations

High‐ and Low‐Affinity Transport of D‐Glucose from Blood to Brain

1981 • 325 citations

Kinetic analysis of blood-brain barrier transport of amino acids

1975 • 306 citations

Handbook of Neurochemistry

1983 • 249 citations

Regional Protein Synthesis in Rat Brain Following Acute Hemispheric Ischemia

1980 • 231 citations

[11C]L-methionine uptake in gliomas

1989 • 212 citations

On the Construction of Functional Maps in Positron Emission Tomography

1984 • 165 citations

Research Methods in Neurochemistry

1974 • 160 citations

Increased amino acid transport into brain tumors measured by PET of L-(2-18F)fluorotyrosine.

1991 • 160 citations

Stereospecificity of blood-brain barrier permeability to amino acids

1973 • 159 citations

Positron Emission Tomography Compared with Magnetic Resonance Imaging and Computed Tomography in Supratentorial Gliomas Using Multiple Stereotactic Biopsies as Reference

1989 • 156 citations

[11C]l-Methionine Uptake in Gliomas

1989 • 152 citations

Positron Emission Tomography of the Brain

1983 • 145 citations

The metabolism of the human brain studied with positron emission tomography

1985 • 143 citations

Brain tumor protein synthesis and histological grades: A study by positron emission tomography (PET) with C11-L-Methionine

1986 • 132 citations

Cerebral metabolism of L-[2-18F]fluorotyrosine, a new PET tracer of protein synthesis.

1989 • 122 citations

Comparison of L-[1-11C]methionine and L-methyl-[11C]methionine for measuring in vivo protein synthesis rates with PET.

1988 • 114 citations

Imaging of brain tumors with L-3-[123I]iodo-alpha-methyl tyrosine and SPECT.

1989 • 112 citations

Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

1986 • 110 citations

Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation.

1988 • 110 citations

PET Study of Methionine Accumulation in Glioma and Normal Brain Tissue

1987 • 104 citations

Positron emission tomography

1985 • 104 citations

Brain and brain tumor uptake of L-3-[123I]iodo-alpha-methyl tyrosine: competition with natural L-amino acids.

1991 • 99 citations

The Metabolism of the Human Brain Studied with Positron Emission Tomography

1985 • 91 citations

Estimation of Local Cerebral Protein Synthesis Rates with L-[1-¹¹C]Leucine and PET: Methods, Model, and Results in Animals and Humans

1989 • 90 citations

Amino acids for the measurement of protein synthesis in vivo by PET

1992 • 87 citations

Comparison of the Accumulation Kinetics of L-(Methyl-¹¹C)-Methionine and D-(Methyl-¹¹C)-Methionine in Brain Tumors Studied with Positron Emission Tomography

1987 • 82 citations

Phenylalanine Transport Across the Blood‐Brain Barrier as Studied with the In Situ Brain Perfusion Technique

1987 • 77 citations

Kinetics of Amino Acid Transport at the Blood‐Brain Barrier Studied Using an in Situ Brain Perfusion Technique

1986 • 72 citations

A strategy for the study of cerebral amino acid transport using iodine-123-labeled amino acid radiopharmaceutical: 3-iodo-alpha-methyl-L-tyrosine.

1991 • 70 citations

In vivo Cerebral Protein Synthesis Rates with Leucyl-Transfer RNA Used as a Precursor Pool: Determination of Biochemical Parameters to Structure Tracer Kinetic Models for Positron Emission Tomography

1989 • 69 citations

Quantitative evaluation of L-[methyl-C-11] methionine uptake in tumor using positron emission tomography.

1989 • 68 citations

Brain Barrier Systems

1968 • 67 citations

Criteria for the tracer kinetic measurement of cerebral protein synthesis in humans with positron emission tomography

1984 • 65 citations

THE BRAIN BARRIER SYSTEM—V STEREOSPECIFICITY OF AMINO ACID UPTAKE, EXCHANGE AND EFFLUX

1963 • 64 citations

Kinetics of influx of phenylalanine, tyrosine, tryptophan, histidine and leucine into slices of brain cortex from adult and 7-day-old rats

1972 • 60 citations

Carbon-11 labelled tyrosine to study tumor metabolism by positron emission tomography (PET)

1986 • 60 citations

Metabolic studies with L-[1-14C]tyrosine for the investigation of a kinetic model to measure protein synthesis rates with PET.

1988 • 57 citations

Phenylalanine Transport at the Human Blood-Brain Barrier

1988 • 55 citations

Positron Emission Tomography Compared with Magnetic Resonance Imaging and Computed Tomography in Supratentorial Gliomas using Multiple Stereotactic Biopsies as Reference

1989 • 55 citations

Local Brain Protein Metabolism in Dementia and Schizophrenia: In Vivo Studies with 11C-L-Methionine and Positron Emission Tomography

1983 • 54 citations

Regional Cerebrovascular Transport of Leucine as Measured by the in situ Brain Perfusion Technique

1985 • 52 citations

Kinetic analysis ofl-leucine transport across the blood-brain barrier

1984 • 47 citations

An In Vivo Kinetic Model with L‐[³⁵S]Methionine for the Determination of Local Cerebral Rates for Methionine Incorporation into Protein in the Rat

1987 • 45 citations

Non selective transport of [11C-methyl]-L-and D-methionine into a malignant glioma

1987 • 44 citations

KINETIC ANALYSIS OF PHENYLALANINE‐INDUCED INHIBITION IN THE SATURABLE INFLUX OF TYROSINE, TRYPTOPHAN, LEUCINE AND HISTIDINE INTO BRAIN CORTEX SLICES FROM ADULT AND 7‐DAY‐OLD RATS

1975 • 42 citations

Uptake of 11C-l-and d-methionine in brain tumors

1985 • 41 citations

Metabolic fate of L-[methyl-11C]methionine in human plasma

1989 • 40 citations

A quantitative autoradiographic method for the measurement of local rates of brain protein synthesis

1982 • 37 citations

Preparation and preliminary tissue studies of optically active 11C-d- and l-phenylalanine

1981 • 36 citations

Assessment of [¹¹C]-L-Methionine Transport into the Human Brain

1988 • 34 citations

Application of a kinetic model on the methionine accumulation in intracranial tumours studied with positron emission tomography.

1987 • 31 citations

Comparison of the Accumulation Kinetics of L-(Methyl-¹¹C)-Methionine and D-(Methyl-¹¹C)-Methionine in Brain Tumors Studied with Positron Emission Tomography

1987 • 31 citations

Transport Inhibition Phenomena in Unilateral Chemical Injury of Blood-Brain Barrier

1968 • 30 citations

Tumor uptake studies of S-adenosyl-l-[methyl-11C]methionine and l-[methyl-11C]methionine

1988 • 29 citations

Measuring Protein Synthesis and Degradation Rates in CNS Tissue

1978 • 28 citations

Biochemical and Autoradiographic Study of Cerebral Protein Synthesis with [¹⁸F]‐ and [¹⁴C]Fluorophenylalanine

1988 • 27 citations

Quantitative Measurements of Regional Glucose Utilization and Rate of Valine Incorporation into Proteins by Double-Tracer Autoradiography in the Rat Brain Tumor Model

1989 • 27 citations

The Transfer Coefficients for L-Valine and the Rate of Incorporation of L-[1-¹⁴C] Valine into Proteins in Normal Adult Rat Brain

1988 • 25 citations

Die Aufnahme von Aminosäuren in Hirntumoren mit der Positronen-Emissionstomographie als Indikator für die Beurteilung von Stoffwechselaktivität und Malignität

1987 • 22 citations

The normal pituitary examined with positron emission tomography and (methyl-11C)-L-methionine and (methyl-11C)-D-methionine

1987 • 21 citations

High uptake of 14C-labeled D-amino acids by various tumors.

1982 • 18 citations

Dynamic study of methionine uptake in glioma using positron emission tomography

1992 • 18 citations

2‐¹⁸F‐phenylalanine and 3‐¹⁸f‐tyrosine — synthesis and preliminary data of tracer kinetics

1988 • 17 citations

Brain tumor imaging with synthesized 18f-fluorophenylalanine and positron emission tomography

1989 • 16 citations

Preferential incorporation of some 14C-labeled D-amino acids into tumor-bearing animals.

1978 • 14 citations

Experimental Application of Triple-Labeled Quantitative Autoradiography for Measurement of Cerebral Blood Flow, Glucose Metabolism, and Protein Biosynthesis

1983 • 14 citations

The Significance of Tryptophan, Phenylalanine, Tyrosine, and Their Metabolites in the Nervous System

1983 • 14 citations

Application of a Kinetic Model on the Methionine Accumulation in Intracranial Tumours Studied with Positron Emission Tomography

1987 • 11 citations

Biological evaluation of radiolabeled D-methionine as a parent compound in potential nuclear imaging.

1984 • 10 citations

11C-labelled glycine: Synthesis and preliminary report on its use in the investigation of intracranial tumours using positron emission tomography

1987 • 10 citations

The slow metabolism of L‐[2‐¹⁸F]‐fluorophenylalanine in rat

1989 • 9 citations

Uptake kinetics of14C L-leucine and14C L- and14C D-methionine in rat brain and incorporation into protein

1987 • 8 citations

Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate

1986 • 8 citations

PET

1989 • 5 citations

Regional transport of phenylalanine across the blood‐brain barrier

1976 • 3 citations

The Accumulation of 11C-Methionine and Histological Grade in Cerebral Glioma Studied with PET

1988 • 2 citations