A Possible Role for Deoxyribonucleotide Pool Imbalances in Carcinogenesis

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

1982 • 1,361 citations

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

The role of gene dosage and genetic transpositions in carcinogenesis

1981 • 670 citations

The origin of human cancers

1981 • 653 citations

The Molecular biology of the yeast saccharomyces, life cycle and inheritance

1981 • 636 citations

THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES

1958 • 634 citations

Translocation and Rearrangements of the c- myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas

1983 • 514 citations

Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

1979 • 488 citations

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

1982 • 471 citations

STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI

1954 • 406 citations

Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency.

1960 • 340 citations

Effects of Thymidine on Deoxyribonucleoside Triphosphate Pools and Deoxyribonucleic Acid Synthesis in Chinese Hamster Ovary Cells

1973 • 299 citations

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1974 • 277 citations

Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis

1981 • 246 citations

Transcriptionally active c- myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia

1983 • 236 citations

FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

1981 • 224 citations

Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.

1978 • 206 citations

Ten model mutagens evaluated by the micronucleus test

1976 • 202 citations

Heritable fragile sites on human chromosomes

1981 • 180 citations

Induction of morphological transformation in mouse C3H/10T1/2 clone 8 cells and chromosomal damage in hamster A(T1)C1-3 cells by cancer chemotherapeutic agents.

1977 • 155 citations

Genetic effects of deoxyribonucleotide pool imbalances

1982 • 144 citations

Chromosome Studies in Patients Treated With Azathioprine and Amethopterin

1967 • 133 citations

STUDIES ON THE INDUCTION OF THYMINE DEFICIENCY AND ON THE EFFECTS OF THYMINE AND THYMIDINE ANALOGUES INESCHERICHIA COLI

1956 • 117 citations

Chromosome aberrations induced by thymidine

1966 • 114 citations

Genetic and biochemical consequences of thymidylate stress

1982 • 101 citations

Further studies on the effect of deoxyadenosine on the accumulation of deoxyadenosine triphosphate and inhibition of deoxyribonucleic acid synthesis in Ehrlich ascites tumor cells in vitro

1962 • 96 citations

Production of sister chromatid exchanges by various cancer chemotherapeutic agents.

1979 • 96 citations

Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA: inhibition of high molecular weight DNA synthesis in human lymphoblastoid cells.

1981 • 94 citations

Cytogenetic effect of methotrexate on human cells in vivo

1979 • 90 citations

Single-strand breaks in bacterial DNA associated with thymine starvation

1969 • 89 citations

Mitotic recombination induced inSaccharomyces cerevisiae with nitrous acid, diethylsulfate and carcinogenic, alkylating nitrosamides

1966 • 88 citations

Gene-amplification model of carcinogenesis.

1981 • 86 citations

Chromosome aberrations in metaphase II-oocytes stage sensitivity in the mouse oogenesis to amethopterin and cyclophosphamide

1974 • 78 citations

CHROMOSOMAL ABNORMALITIES PRODUCED BY FOLIC ACID ANTAGONISTS.

1965 • 76 citations

Suppression of Chemical Mutagenesis in Bacteriophage T4 by Genetically Modified DNA Polymerases

1970 • 76 citations

Induction of mitotic recombination in yeast by starvation for thymine nucleotides.

1980 • 72 citations

Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.

1976 • 69 citations

Isolation and characterization of yeast mutants auxotrophic for 2′-deoxythymidine 5′-monophosphate

1979 • 69 citations

Rapid changes in deoxynucleoside triphosphate pools in mammalian cells treated with mutagens

1983 • 68 citations

The genotoxic potential of bases and nucleosides

1981 • 60 citations

Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate

1981 • 58 citations

Ataxia telangiectasia: The effects of chemical mutagens and x-rays on sister chromatid exchanges in blood lymphocytes

1977 • 57 citations

DNA repair and the genetic effects of thymidylate stress in yeast

1982 • 54 citations

Enhanced mitotic recombination in a ligase-defective mutant of the yeast Saccharomyces cerevisiae.

1979 • 53 citations

The fragile X(q27) form of X‐linked mental retardation: FUdR as an inducing agent for fra(X)(q27) expression in lymphocytes, fibroblasts, and amniocytes

1982 • 50 citations

Induction of virus synthesis in polyoma-transformed cells by DNA antimetabolites and by irradiation after pretreatment with 5-bromodeoxyuridine

1972 • 43 citations

Induction of sister-chromatid exchanges (SCEs) by thymidine and the potentiation of mutagen-induced SCEs in Chinese hamster ovary cells

1983 • 40 citations

Cytogenetic Evaluation of Methotrexate-Treated Psoriatic Patients

1969 • 37 citations

Double-strand scission of DNA involved in thymineless death of Escherichia coli 15 TAU

1973 • 35 citations

Loss of Deoxyribonucleic Acid-Thymine During Thymine Starvation of Escherichia coli

1972 • 35 citations

Human mitotic and meiotic chromosome damage following in vivo exposure to methotrexate

1971 • 34 citations

Responses of Chinese Hamster and L Cells to 2′-Deoxy-5-Fluoro-Uridine and Thymidine<xref ref-type="fn" rid="FN2">2</xref>

1964 • 34 citations

REPLICATIVE FRAGMENTATION IN T4 BACTERIOPHAGE DNA, II. BIPARENTAL MOLECULAR RECOMBINATION

1964 • 31 citations

“Thymineless death” in a strain of Saccharomyces cerevisiae auxotrophic for deoxythymidine-5′-monophosphate

1974 • 31 citations

Sterically hindered aromatic compounds. XI. Spectral and product studies of the decomposition of N-nitrosoacetanilides

1982 • 27 citations

Chromosome Damage Induced by 5-Fluoro-2′ -Deoxyuridine in Relation to the Cell Cycle of the Chinese Hamster<xref ref-type="fn" rid="FN2">2</xref>

1968 • 27 citations

Induction of sister-chromatid exchange by 5-substituted 2′-deoxyuridines

1983 • 26 citations

MEASUREMENT OF THE STABILITY OF THE REPRESSOR OF ALKALINE PHOSPHATASE SYNTHESIS IN ESCHERICHIA COLI

1964 • 25 citations

Effect of Chemotherapeutic Agents on Chromosomes of Patients with Lung Cancer

1969 • 21 citations

Critical periods of the mitotic cycle: Influence of aminopterin and thymidine on production of chromosomal aberrations by radiation in Crepis capillaris

1976 • 20 citations

The effects of thymine deprivation on the synthesis of protein in Escherichia coli

1962 • 20 citations

On the mechanism of mitotic recombination in Aspergillus nidulans

1967 • 19 citations

Variation of mutation and recombination frequencies over a range of thymidylate concentrations in a diploid thymidylate auxotroph

1983 • 19 citations

The reproducibility of individual estimations in the covalent binding of N-acetoxy-2-acetylaminoflourene to DNA and in the induction of unscheduled DNA synthesis

1983 • 19 citations

Induction of polyploidy by concentrated thymidine

1971 • 18 citations

The effects of thymine deprivation on the synthesis of protein in Escherichia coli

1962 • 18 citations

The effect of 5-bromouracil on recombination of phage lambda

1976 • 18 citations

Cytological aberrations produced by methotrexate in mouse ascites tumours

1972 • 18 citations

A simple, rapid plate assay for mitotic recombination

1980 • 12 citations

Inhibition of thymidylate biosynthesis induces mitotic unequal sister chromatid recombination in Saccharomyces cerevisiae

1984 • 11 citations

The effect of pyrimethamine on the human chromosomes.

1965 • 8 citations

The effect of thymine deprivation on protein synthesis in Escherichia coli

1964 • 4 citations