A tyrosine-containing motif mediates ER retention of CD3-epsilon and adopts a helix-turn structure.

A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

1980 • 1,886 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA

1991 • 787 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Polypeptide secondary structure determination by nuclear magnetic resonance observation of short proton-proton distances

1984 • 756 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Coatomer Interaction with Di-Lysine Endoplasmic Reticulum Retention Motifs

1994 • 574 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway

1990 • 548 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

1989 • 499 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Retrieval of transmembrane proteins to the endoplasmic reticulum.

1993 • 414 citations

Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum

1992 • 396 citations

Stabilization of the ribonuclease S‐peptide α‐helix by trifluoroethanol

1986 • 381 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum.

1994 • 315 citations

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.

1993 • 258 citations

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

1991 • 246 citations

Retention of Unassembled Components of Integral Membrane Proteins by Calnexin

1994 • 243 citations

The ERD2 gene determines the specificity of the luminal ER protein retention system

1990 • 243 citations

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor.

1987 • 232 citations

pH-dependent binding of KDEL to its receptor in vitro.

1993 • 232 citations

TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain.

1993 • 231 citations

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.

1989 • 228 citations

Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG

1992 • 173 citations

The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1.

1993 • 169 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor.

1992 • 144 citations

A tyrosine-based motif in the cytoplasmic domain of the alphavirus envelope protein is essential for budding.

1994 • 141 citations

The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells.

1993 • 108 citations

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.

1991 • 98 citations

Transmembrane signalling through the T-cell-receptor-CD3 complex

1993 • 98 citations

A conformational epitope expressed upon association of CD3-epsilon with either CD3-delta or CD3-gamma is the main target for recognition by anti-CD3 monoclonal antibodies.

1991 • 97 citations

Transplanted LDL and mannose-6-phosphate receptor internalization signals promote high-efficiency endocytosis of the transferrin receptor.

1991 • 93 citations

Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells

1991 • 92 citations

The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits.

1985 • 76 citations

T cell receptor complexes containing Fc epsilon RI gamma homodimers in lieu of CD3 zeta and CD3 eta components: a novel isoform expressed on large granular lymphocytes.

1992 • 72 citations

Surface expression of alternative forms of the TCR/CD3 complex.

1991 • 68 citations

An endoplasmic reticulum retention signal in the CD3ɛ chain of the T-cell receptor

1992 • 67 citations

Mutational analysis of the cytoplasmic tail of the human transferrin receptor. Identification of a sub-domain that is required for rapid endocytosis.

1991 • 63 citations

The structure of an endocytosis signal

1992 • 56 citations

Antigen Receptors on T and B Lymphocytes: Parallels in Organization and Function

1993 • 52 citations

Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post‐endoplasmic reticulum compartment

1989 • 37 citations

Tail-specific antibodies that block return of 46,000 M(r) mannose 6-phosphate receptor to the trans-Golgi network

1993 • 28 citations

[11] Rotating-frame nuclear Overhauser effect

1989 • 19 citations

Different functional domains on the transferrin receptor molecule defined by monoclonal antibodies.

1989 • 11 citations

Human genomic sequences corresponding to murine CD3η‐related transcripts: Lack of conservation or expression of homologous human products

1992 • 8 citations

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