Regulation of Gene Expression in the Normal and Overloaded Heart

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles

1986 • 657 citations

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

1984 • 609 citations

The Complete Amino Acid Sequence of Actins from Bovine Aorta, Bovine Heart, Bovine Fast Skeletal Muscle, and Rabbit, Slow Skeletal Muscle

1979 • 534 citations

Myosin isoenzyme redistribution in chronic heart overload

1979 • 524 citations

Alternative transcription and two modes of splicing result in two myosin light chains from one gene

1984 • 400 citations

Myosin isoenzyme changes in several models of rat cardiac hypertrophy.

1981 • 400 citations

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

1983 • 393 citations

Myosin isoenzymic distribution correlates with speed of myocardial contraction

1981 • 357 citations

Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals

1981 • 354 citations

Muscle development--molecular and cellular control

1982 • 344 citations

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

1984 • 320 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA

1982 • 295 citations

Myosin isoenzymes in normal and hypertrophied human ventricular myocardium.

1983 • 279 citations

Molecular characterization of two myosin heavy chain genes expressed in the adult heart

1982 • 277 citations

α-Skeletal and α-Cardiac Actin Genes Are Coexpressed in Adult Human Skeletal Muscle and Heart

1983 • 237 citations

Number and organization of actin-related sequences in the mouse genome

1983 • 232 citations

Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross

1985 • 175 citations

Measurements of half-life of rat cardiac myosin heavy chain with leucyl-tRNA used as precursor pool.

1977 • 167 citations

Expression of the genes coding for the skeletal muscle and cardiac actins in the heart

1984 • 157 citations

A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene

1984 • 157 citations

Molecular structure and evolutionary origin of human cardiac muscle actin gene.

1982 • 155 citations

Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I.

1981 • 150 citations

Sarcomeric myosin heavy chain is coded by a highly conserved multigene family.

1982 • 147 citations

Multigene Family for Sarcomeric Myosin Heavy Chain in Mouse and Human DNA: Localization on a Single Chromosome

1983 • 141 citations

cDNA clone analysis of six co-regulated mRNAs encoding skeletal muscle contractile proteins.

1982 • 139 citations

Comparison of turnover of several myofibrillar proteins and critical evaluation of double isotope method.

1977 • 129 citations

α-Cardiac Actin Is the Major Sarcomeric Isoform Expressed in Embryonic Avian Skeletal Muscle

1984 • 126 citations

alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart.

1983 • 121 citations

Comparison of α-tropomyosin sequences from smooth and striated muscle

1985 • 114 citations

Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin.

1982 • 107 citations

The metabolism of myosin, the meromyosins, actin and tropomyosin in the rabbit

1956 • 98 citations

Isolation and characterization of human myosin heavy chain genes.

1983 • 96 citations

The myosin alkali light chains of mouse ventricular and slow skeletal muscle are indistinguishable and are encoded by the same gene.

1985 • 95 citations

Myosin Synthesis and Degradation during Development of Cardiac Hypertrophy in the Rabbit

1972 • 87 citations

Equilibration of leucine between the plasma compartment and leucyl-tRNA in the heart, and turnover of cardiac myosin heavy chain

1981 • 78 citations

Influence of thyroid hormone on the in vitro translational activity of specific mRNAs in the rat heart.

1983 • 78 citations

Heart failure: An electron microscopic study of the left ventricular papillary muscle in aortic insufficiency in the rabbit

1970 • 75 citations

The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.

1982 • 69 citations

Protein synthesis and degradation in cardiac stress.

1981 • 67 citations

Metabolism of myosin and life time of myofibrils

1960 • 66 citations

Easily releasable myofilaments from skeletal and cardiac muscles maintained in vitro. Role in myofibrillar assembly and turnover.

1981 • 60 citations

Assessment of fractional rates of protein synthesis in cardiac muscle cultures after equilibrium labeling.

1981 • 55 citations

Myofibrillar protein turnover. Synthesis of protein-bound 3-methylhistidine, actin, myosin heavy chain and aldolase in rat skeletal muscle in the fed and starved states

1983 • 52 citations

Isolation of newly synthesised myosin filaments from skeletal muscle homogenates and myofibrils

1975 • 52 citations

Studies on the Synthesis and Degradation of Light and Heavy Chains of Cardiac Myosin

1973 • 51 citations

Distinct α‐Tropomyosin mRNA Sequences in Chicken Skeletal Muscle

1982 • 51 citations

Turnover Rates of Various Muscle Proteins

1974 • 49 citations

Über die Retikulosen und das Problem der Leukaemien

1949 • 47 citations

Polyamine and nucleic acid metabolism in myocardial hypertrophy of the overloaded heart

1974 • 45 citations

Overview on pathogenesis of cardiac hypertrophy.

1974 • 43 citations

Comparison of myosin synthesis in heart and red and white skeletal muscles

1971 • 42 citations

Redistribution of creatine kinase isoenzymes in chronically overloaded myocardium

1985 • 41 citations

Different distributions of microtubules, desmin filaments and isomyosins during the onset of cardiac hypertrophy in the rat.

1984 • 40 citations

NONUNIFORM RATES OF TURNOVER OF MYOFIBRILLAR PROTEINS IN RAT DIAPHRAGM

1973 • 40 citations

Heterogeneous Turnover of Myofibrillar Protein

1972 • 37 citations

Effect of acute overload on protein synthesis in cardiac muscle microsomes

1967 • 36 citations

Quantitation of myosin in muscle

1983 • 35 citations

The Metabolism of Myosin and the Meromyosins from Rabbit Skeletal Muscle

1966 • 33 citations

Protein synthesis during systolic and diastolic cardiac overloading in rats: a comparative study

1981 • 30 citations

Turnover Rates of Structural Proteins of Rabbit Skeletal Muscle*

1974 • 30 citations

Early changes in myocardial protein synthesis in vivo in response to right ventricular pressure overload in the dog

1979 • 29 citations

Construction of bacterial plasmids containing sequences complementary to chicken α-tropomyosin mRNA

1981 • 29 citations

Myosin heavy chain and actin fractional rates of synthesis in normal and overload rat heart ventricles

1984 • 27 citations

Effect of diabetes and hypothyroidism on the predominance of cardiac myosin heavy chains synthesized in vivo or in a cell-free system.

1984 • 23 citations

The nucteotide sequence of myodn light chain (L-2A) mRNA from embryonic chicken cardiac muscle tissue

1983 • 23 citations

Comparison of the synthesis of the light and heavy chains of adult skeletal myosin

1973 • 21 citations

TURNOVER RATES OF MUSCLE PROTEIN IN CARDIAC AND SKELETAL MUSCLES OF DOG, FOWL, RAT AND MOUSE: TURNOVER RATE RELATED TO MUSCLE FUNCTION

1978 • 19 citations

Turnover of myosin heavy and light chains in cultured embryonic chick cardiac and skeletal muscle

1976 • 18 citations

Relative synthesis of cardiac contractile proteins. Evidence for synthesis from the same precursor pool

1981 • 17 citations

Lactate dehydrogenase isoenzymes in the human hypertrophic heart

1977 • 17 citations

The synthesis of myosin, actin and the major protein fractions in rabbit skeletal muscle

1979 • 17 citations

Messenger RNA content and complexity in normal and overloaded rat heart

1987 • 16 citations

Messenger RNA content and complexity in normal and overloaded rat heart: A preliminary report

1984 • 15 citations

Synthesis of myosin heavy and light chains in the afterloaded guinea pig right ventricle

1978 • 14 citations

Myosin heavy chain mRNA during the development and regression of myocardial hypertrophy

1984 • 9 citations

Muscle and nonmuscle cell RNA polymerase activities in early myocardial hypertrophy

1981 • 8 citations

The incorporation of radioactive lysine or tyrosine into cardiac and skeletal myofibrillar and non-myofibrillar contractile proteins.

1980 • 6 citations

Synthesis of guinea-pig cardiac myosin as measured by constant infusion

1978 • 6 citations

Separation of the mRNAs coding for α and β‐tropomyosin

1981 • 5 citations

Hypertrophied rat heart. New Na+, K+-ATPaseouabain interactions in sarcolemma vesicles

1984 • 5 citations

The Role of Protein Synthesis and Degradation in Cardiac Growth

1984 • 3 citations

Hypertrophied rat heart. New Na+/K+ ATPase-ouabain interactions in sarcolemma vesicles? I/ Isolation of sarcolemma and ouabain-binding

1983 • 1 citations