Prion protein interactions with nucleic acid: possible models for prion disease and prion function.

Prions

1998 • 5,102 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

Adaptive Recognition by Nucleic Acid Aptamers

2000 • 1,522 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

Prion Protein Biology

1998 • 913 citations

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1995 • 835 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

A Transmembrane Form of the Prion Protein in Neurodegenerative Disease

1998 • 724 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible

1997 • 666 citations

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

2001 • 663 citations

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing

1993 • 578 citations

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

1997 • 515 citations

Crystal structure of the human prion protein reveals a mechanism for oligomerization.

2001 • 508 citations

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

1996 • 506 citations

RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments

1996 • 502 citations

Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 • 497 citations

Abnormal fibrils from scrapie-infected brain

1981 • 473 citations

Location and properties of metal-binding sites on the human prion protein

2001 • 471 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

First Glimpses at Structure-function Relationships of the Nucleocapsid Protein of Retroviruses

1995 • 402 citations

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

2001 • 371 citations

Copper Binding to the N-Terminal Tandem Repeat Regions of Mammalian and Avian Prion Protein

1995 • 353 citations

A 'unified theory' of prion propagation

1991 • 304 citations

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes

2002 • 261 citations

Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126

2001 • 261 citations

Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.

1993 • 241 citations

Prion research: the next frontiers

1997 • 221 citations

RNA aptamers specifically interact with the prion protein PrP

1997 • 212 citations

Molecular Characteristics of a Protease-Resistant, Amyloidogenic and Neurotoxic Peptide Homologous to Residues 106-126 of the Prion Protein

1993 • 208 citations

DNA Converts Cellular Prion Protein into the β-Sheet Conformation and Inhibits Prion Peptide Aggregation

2001 • 202 citations

Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells.

1991 • 198 citations

Tetracyclines affect prion infectivity

2002 • 192 citations

Protease-resistant prion protein produced in vitro lacks detectable infectivity.

1999 • 188 citations

The Prion Protein Has RNA Binding and Chaperoning Properties Characteristic of Nucleocapsid Protein NCp7 of HIV-1

2001 • 182 citations

Proposed three-dimensional structure for the cellular prion protein.

1994 • 179 citations

Conformational Transformations in Peptides Containing Two Putative α-Helices of the Prion Protein

1995 • 178 citations

BSE and Prions: Uncertainties About the Agent

1998 • 177 citations

Prion protein and the transmissible spongiform encephalopathies

1997 • 168 citations

Protein secondary structural types are differentially coded on messenger RNA

1996 • 160 citations

Transmission of prions

2002 • 159 citations

The prion folding problem

1997 • 151 citations

Prion Rods Contain Small Amounts of Two Host Sphingolipids as Revealed by Thin-Layer Chromatography and Mass Spectrometry

1998 • 143 citations

Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis

1992 • 131 citations

Attempts to restore scrapie prion infectivity after exposure to protein denaturants.

1993 • 130 citations

Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.

1986 • 126 citations

Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques

1999 • 123 citations

The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein 1 1Edited by J. Karn

2001 • 121 citations

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus 1 1Edited by F. Cohen

2000 • 115 citations

Infectious Etiology of Neuritic (Senile) Plaques in Mice

1975 • 113 citations

Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide

2002 • 108 citations

Non-Watson-Crick base pairs in RNA-protein recognition

1999 • 105 citations

Mammalian prion proteins

2000 • 89 citations

A Monomer-Dimer Equilibrium of a Cellular Prion Protein (PrPC) Not Observed with Recombinant PrP

2000 • 87 citations

Polymerization of murine recombinant prion protein in nucleic acid solution

1999 • 87 citations

Infection specific prion protein (PrP) accumulates on neuronal plasmalemma in scrapie infected mice

1992 • 79 citations

Transmission of Prions

2002 • 74 citations

Protease-resistant and Detergent-insoluble Prion Protein Is Not Necessarily Associated with Prion Infectivity

1999 • 71 citations

1 An Introduction to Prion Biology and Diseases

2004 • 71 citations

The Role of Prion Peptide Structure and Aggregation in Toxicity and Membrane Binding

2000 • 70 citations

A Modified Host Protein Model of Scrapie

2007 • 69 citations

Controlling Polymerization of β-Amyloid and Prion-derived Peptides with Synthetic Small Molecule Ligands

2000 • 69 citations

Cell-Lysate Conversion of Prion Protein into Its Protease-Resistant Isoform Suggests the Participation of a Cellular Chaperone

1999 • 69 citations

In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies

1997 • 68 citations

Cytotoxicity of Prion Protein Peptide (PrP106–126) Differs in Mechanism from the Cytotoxic Activity of the Alzheimer's Disease Amyloid Peptide, Aβ25–35

1996 • 67 citations

Prion Rods Contain an Inert Polysaccharide Scaffold

1999 • 66 citations

Reconstitution of Prion Infectivity from Solubilized Protease-resistant PrP and Nonprotein Components of Prion Rods

2001 • 62 citations

Molecular biology of prion diseases

1994 • 59 citations

Prion Protein Contains a Second Endoplasmic Reticulum Targeting Signal Sequence Located at Its C Terminus

2001 • 52 citations

Cleavage of p15 protein in vitro by human immunodeficiency virus type 1 protease is RNA dependent

1994 • 50 citations

Interaction of prion peptide HuPrP106–126 with nucleic acid

1997 • 44 citations

Polymerization of human prion peptide HuPrP 106–126 to amyloid in nucleic acid solution

1998 • 42 citations

PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1

2002 • 41 citations

Analysis of the incubation periods, induction of obesity and histopathological changes in senescence-prone and senescence-resistant mice infected with various scrapie strains.

1998 • 39 citations

Pseudoknots in prion protein mRNAs confirmed by comparative sequence analysis and pattern searching

2001 • 37 citations

βAPP and Furin mRNA Concentrates in Immature Senile Plaques in the Brain of Alzheimer Patients

2002 • 35 citations

Modeling a Prion Protein Dimer: Predictions for Fibril Formation

2000 • 35 citations

Concentration and removal of prion proteins from biological solutions

2003 • 34 citations

2 Development of the Prion Concept

1999 • 32 citations

Murine recombinant prion protein induces ordered aggregation of linear nucleic acids to condensed globular structures

2001 • 30 citations

Scrapie strain-specific interactions with endogenous murine leukaemia virus.

1999 • 29 citations

Prions and nucleic acids: search for "residual" nucleic acids and screening for mutations in the PrP-gene.

1993 • 27 citations

5 Structural Studies of Prion Proteins

2004 • 15 citations

Relationship of protease-resistant protein, scrapie-associated fibrils and tubulofilamentous particles to the agent of spongiform encephalopathies

1992 • 10 citations

16 RNA Interaction with Small Ligands and Peptides

1999 • 9 citations

Evidence that single-stranded DNA wrapped around the tubulofilamentous particles termed “nemaviruses” is the genome of the scrapie agent

1998 • 9 citations

PRION RESEARCH ACCELERATES

1998 • 3 citations

Deleted Work

1955 • 0 citations