In vitro testing of the immune response

Immunochemical quantitation of antigens by single radial immunodiffusion

1965 • 9,369 citations

Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

1966 • 2,470 citations

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

Experimental Immunochemistry

1962 • 1,576 citations

Fluorescent Antibody Methods

1969 • 1,549 citations

Antigen-antibody crossed electrophoresis

1965 • 1,460 citations

In vitro methods in cell-mediated and tumor immunity

1976 • 1,266 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

INFECTION AND NITROBLUE-TETRAZOLIUM REDUCTION BY NEUTROPHILS

1968 • 723 citations

Demonstration of cell‐mediated immunity to human neoplasms of various histological types

1971 • 673 citations

PRODUCTION OF EMBRYONAL α-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMAS

1963 • 601 citations

Human Lymphocyte Migration as a Parameter of Hypersensitivity

1967 • 563 citations

Thymus-Derived Rosette-Forming Cells in Various Human Disease States: Cancer, Lymphoma, Bacterial and Viral Infections, and Other Diseases

1973 • 561 citations

In vitro Cell Migration as a Model for Delayed Hypersensitivity.

1962 • 555 citations

The Immune-Adherence Phenomenon

1953 • 487 citations

A MICROASSAY FOR CELL-MEDIATED IMMUNITY

1970 • 486 citations

LYMPHOPENIA AND CHANGE IN DISTRIBUTION OF HUMAN B AND T LYMPHOCYTES IN PERIPHERAL BLOOD INDUCED BY IRRADIATION FOR MAMMARY CARCINOMA

1972 • 462 citations

Fluorescent Antibody Methods

1968 • 436 citations

Antibodies to Epstein-Barr Virus in Nasopharyngeal Carcinoma, Other Head and Neck Neoplasms, and Control Groups<xref ref-type="fn" rid="FN2">2</xref>

1970 • 405 citations

Tumour-specific Antibodies in Human Malignant Melanoma and their Relationship to the Extent of the Disease

1969 • 396 citations

THE CELLULAR BASIS OF IMMUNOLOGICAL RESPONSES

1969 • 396 citations

Demonstration of antibodies against human malignant melanoma by immunofluorescence.

1968 • 390 citations

Cellular and Humoral immunity to Different Types of Human Neoplasms

1968 • 386 citations

Impaired in Vitro Lymphocyte Transformation in Hodgkin's Disease

1965 • 379 citations

DEPRESSED CELL-MEDIATED IMMUNITY IN PATIENTS WITH PRIMARY INTRACRANIAL TUMORS

1972 • 365 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Kaposi's sarcoma in Uganda: A clinico‐pathological study

1971 • 333 citations

IMMUNOSUPPRESSIVE EFFECT OF SURGERY

1971 • 314 citations

Search for tumor-specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction.

1966 • 312 citations

Precise Standardization of Reagents for Complement Fixation

1963 • 312 citations

Demonstration of cell-bound and humoral immunity against neuroblastoma cells.

1968 • 307 citations

Immunology and Biochemistry of Regan Isoenzyme of Alkaline Phosphatase in Human Cancer

1968 • 298 citations

Impaired Lymphocyte Function in Untreated Hodgkin's Disease

1974 • 294 citations

Antigenic Properties of Lymphomas Induced by the Moloney Agent<xref ref-type="fn" rid="FN2">2</xref>

1964 • 286 citations

SERUM-MEDIATED PROTECTION OF NEOPLASTIC CELLS FROM INHIBITION BY LYMPHOCYTES IMMUNE TO THEIR TUMOR-SPECIFIC ANTIGENS

1969 • 264 citations

Leukocyte adherence inhibition: A simple test for cell‐mediated tumour immunity and serum blocking factors

1972 • 251 citations

Chemotherapy, Immunocompetence, Immunosuppression and Prognosis in Acute Leukemia

1971 • 248 citations

LYMPHOCYTE SENSITISATION: AN IN-VITRO TEST FOR CANCER ?

1970 • 247 citations

TUBERCULIN‐INDUCED MIGRATION INHIBITION OF HUMAN PERIPHERAL LEUCOCYTES IN AGAROSE MEDIUM

1971 • 243 citations

Cellular immunity to human urinary bladder carcinoma. I. Correlation to clinical stage and radiotherapy

1972 • 225 citations

Lymphocyte reactivity in cancer patients: Correlation with tumor histology and clinical stage

1973 • 221 citations

Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease.

1972 • 206 citations

Immune response to urinary bladder tumours in man

1970 • 203 citations

REACTIVE LYSIS: THE COMPLEMENT-MEDIATED LYSIS OF UNSENSITIZED CELLS

1970 • 198 citations

Colony inhibition studies on blocking and non‐blocking serum effects on cellular immunity to moloney sarcomas

1970 • 197 citations

Epstein‐Barr virus (EBV)‐associated antibody patterns in malignant lymphoma and leukemia. I. Hodgkin's disease

1970 • 193 citations

Human Osteosarcomas: Immunologic Evidence Suggesting an Associated Infectious Agent

1968 • 193 citations

POSTOPERATIVE DEPRESSION OF THE LYMPHOCYTE RESPONSE TO PHYTOHÆMAGGLUTININ

1967 • 190 citations

Postoperative Depression of Tumour-directed Cell-mediated Immunity in Patients with Malignant Disease

1972 • 183 citations

Circulating immune complexes in inflammatory bowel disease.

1973 • 179 citations

Cell-mediated antitumor immunity in breast cancer patients evaluated by antigen-induced leukocyte adherence inhibition in test tubes.

1975 • 172 citations

Studies on cellular immunity to human neuroblastoma cells

1970 • 165 citations

Immunodeficiency Disease and Malignancy

1972 • 163 citations

CELL INTERACTIONS IN THE IMMUNE RESPONSE IN VITRO

1972 • 155 citations

COMPONENTS OF GUINEA PIG COMPLEMENT

1963 • 153 citations

A micro-method for peripheral leucocyte migration in tuberculin sensitivity

1971 • 153 citations

The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission.

1971 • 150 citations

Biological markers in breast carcinoma.I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides

1975 • 145 citations

Retrogenetic Expression: the Reappearance of Embryonal Antigens in Cancer Cells

1970 • 134 citations

In Vitro Lymphocyte Stimulation by a Soluble Antigen from Malignant Melanoma

1970 • 131 citations

Inhibition of Leukocyte Migration by Tumor-Associated Antigens in Soluble Extracts of Human Breast Carcinoma 2

1974 • 131 citations

Natural Antibody in Human Serum to a Neoantigen in Human Cultured Cells Grown in Fetal Bovine Serum2

1974 • 130 citations

Role of macrophages in tumour immunity. I. Co-operation between macrophages and lymphoid cells in syngeneic tumour immunity.

1972 • 126 citations

Cellular and humoral immunity against human malignant melanoma

1971 • 120 citations

Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis

1971 • 118 citations

Correlation of in vivo and in vitro assays of immunocompetence in cancer patients.

1974 • 115 citations

Effect of autologous mammary tumour extracts on human leukocyte migration in vitro

1970 • 108 citations

Cytotoxic and neutralization tests with serum and lymph node cells of isologous mice with induced resistance against gross lymphomas.

1962 • 107 citations

Measurements of Complement by Agglutination of Human Erythrocytes Reacting in Immune-Adherence

1963 • 107 citations

IN VITRO MIGRATION OF PERIPHERAL HUMAN LEUCOCYTES IN CELLULAR HYPERSENSITIVITY

1968 • 107 citations

Detection of Anti-tumour Cell Mediated Immunity and Serum Blocking Factors in Cancer Patients by the Leucocyte Adherence Inhibition Test

1974 • 105 citations

Inhibition of in vitro lymphocyte transformation during chemotherapy in man.

1967 • 104 citations

Possibilities and Problems of Immunologic Intervention in Cancer

1972 • 104 citations

Impaired responsiveness of lymphocytes and serum-inhibitory factors in patients with cancer.

1973 • 103 citations

Cytotoxic lymphocytes in melanoma patients

1972 • 102 citations

Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast

1972 • 99 citations

Antigen-mediated macrophage adherence inhibition

1974 • 96 citations

Tube leukocyte adherence inhibition assay for the detection of anti‐tumour immunity. II. Monocyte reacts with tumour antigen via cytophilic anti‐tumour antibody

1976 • 93 citations

Leukocyte function in patients with leukemia

1970 • 92 citations

Inhibition of lymphocyte cytotoxicity for human colon carcinoma by treatment with solubilized tumour membrane fractions

1973 • 89 citations

In vitro study of cellular immunity against autochthonous human cancer

1972 • 85 citations

HOST ENVIRONMENT INTERACTIONS IN THE ETIOLOGY OF CANCER IN MAN

1973 • 85 citations

Choriocarcinoma: The clinical biology of the trophoblast and its tumours

1969 • 85 citations

Elevated IgA in carcinoma of the nasopharynx

1975 • 82 citations

Decreased Nitroblue Tetrazolium Dye Reduction in the Phagocytes of Patients Receiving Prednisone

1970 • 80 citations

SPECIFIC ANTIBODIES IN HEART-DISEASE

1961 • 79 citations

Use of a ‘Mixed Hæmadsorption’ Method in Virus-infected Tissue Cultures

1961 • 79 citations

EBV‐Associated serological patterns in a burkitt lymphoma patient during regression and recurrence

1969 • 78 citations

COMPONENTS OF GUINEA PIG COMPLEMENT

1963 • 77 citations

Blood Lymphocytes after Radiation Therapy of Mammary Carcinoma

1974 • 76 citations

ANTINUCLEAR ANTIBODIES IN PATIENTS WITH MALIGNANCIES

1972 • 75 citations

Transient Bactericidal Defect of Peripheral Blood Phagocytes from Children with Acute Lymphoblastic Leukemia Receiving Craniospinal Irradiation

1973 • 75 citations

Leukocyte adherence inhibition and specific immunoreactivity in malignant melanoma

1975 • 75 citations

Significance of the Changes in the Circulating Lymphoid Cells in Hodgkin's Disease

1969 • 74 citations

Cell-Mediated Immunity and Specific Serum Factors in Human Cancer: The Leukocyte Adherence Inhibition Test2

1974 • 74 citations

Effects of Local Irradiation (Co60 Teletherapy) on the Peripheral Blood and Bone Marrow

1963 • 73 citations

Demonstration of H-2 isoantigens and polyoma specific tumor antigens by measuring colony formation in vitro

1965 • 70 citations

MACROPHAGE-ELECTROPHORETIC-MOBILITY (M.E.M.) TEST FOR MALIGNANT DISEASE

1972 • 70 citations

Cellular immunity to human breast carcinoma

1972 • 70 citations

Immune alterations in Hodgkin's disease. Effect of delayed hypersensitivity and lymphocyte transformation on course and survival

1973 • 68 citations

Cellular immunity to nephroblastoma

1971 • 68 citations

Leukocyte function in patients with leukemia

1970 • 67 citations

Inhibition of Leukocyte Migration by Tumor-Associated Antigens in Soluble Extracts of Human Malignant Melanoma2

1975 • 67 citations

Immunological Reactivity in Patients with Carcinoma of Colon

1971 • 66 citations

Antigen Solubilized from Human Solid Tumours: Lymphocyte Stimulation and Cutaneous Delayed Hypersensitivity

1973 • 65 citations

Effect of previous irradiation on the transformation of blood lymphocytes

1965 • 65 citations

Depression of lymphocyte replicating ability in radiotherapy patients

1974 • 64 citations

Immunological Aspects of Burkitt' Lymphoma

1971 • 62 citations

FORMATION OF CYTOXIC ANTIBODY AGAINST LEUKEMIAS INDUCED BY FRIEND VIRUS.

1963 • 59 citations

HUMAN SARCOMAS IN CULTURE

1971 • 58 citations

Serum-Mediated Inhibition of Lymphocyte Stimulation by Autochthonous Human Tumors<xref ref-type="fn" rid="FN2">2</xref>

1971 • 56 citations

Sensitization to tumour‐associated antigens in human breast carcinoma

1974 • 55 citations

DIFFERENCES BETWEEN THE ACTIVITIES OF MATURE GRANULOCYTES IN LEUKEMIC AND NORMAL BLOOD 1

1954 • 52 citations

Inhibition of migration of human autogenous and allogeneic leukocytes by extracts of patients' cancers.

1971 • 52 citations

Specific responsiveness of leukocytes to soluble extracts of human tumors

1975 • 51 citations

Présence D'une Ferroprotéine D'origine Tissulaire, L'α₂H, dans le Sérum des Enfants Porteurs de Tumeurs

1970 • 51 citations

Leukocyte function in children with malignancies

1975 • 51 citations

Delayed Hypersensitivity in Cancer Patients: Cutaneous and <italic>In Vitro</italic> Lymphocyte Response to Specific Antigens<xref ref-type="fn" rid="FN2">2</xref>

1969 • 50 citations

A rapid, sensitive and specific radioimmunoassay for human chorionic gonadotrophin

1976 • 50 citations

The metabolic and phagocytic activities of leukocytes from children with acute leukemia.

1970 • 49 citations

Cellular immunity in human malignant melanoma and melanoma histology

1973 • 49 citations

CELL-MEDIATED IMMUNITY IN MALIGNANT MELANOMA

1972 • 48 citations

Attempts to induce immunity against mammary adenocarcinoma in inbred mice.

1953 • 48 citations

Expression of cell surface markers on T and B lymphocytes after long-term chemotherapy of acute leukemia

1973 • 47 citations

Evaluation of the leucocyte migration test as a measure of delayed hypersensitivty in man. Suppression of migration inhibition by puromycin.

1972 • 47 citations

Blocking effect of serum from tumor-bearing animals on macrophage migration inhibition with tumor antigens.

1971 • 47 citations

Evaluation of Cell-Mediated Cytotoxic Reactivity Against Tumor Associated Antigens with 125I-Iododeoxyuridine Labeled Target Cells

1973 • 46 citations

A new white cell test which measures individual phagocyte function in a mixed leukocyte population. I. A neutrophil defect in acute myelocytic leukemia.

1973 • 46 citations

Salivary immunoglobulins in patients with oropharyngeal and bronchopulmonary carcinoma

1973 • 46 citations

Inhibition of leucocyte migration by tumour-associated antigens of the colon and rectum

1973 • 45 citations

Immunity and immunopathology in virus infections.

1972 • 44 citations

Prelabeling target cells with 3 H-proline as a method for studying lymphocyte cytotoxicity.

1973 • 44 citations

Production of migration inhibitory factor and lympl toxin by non‐T cells

1975 • 44 citations

Specific Immune Response in Human Skin Carcinoma

1971 • 44 citations

Variations in the level of a pregnancy-associated alpha-macroglobulin in patients with cancer.

1975 • 43 citations

Lymphocyte blastogenesis to human leukemia cells and their relationship to serum factors, immunocompetence, and prognosis.

1972 • 43 citations

Formation of auto-rosettes by peripheral blood lymphocytes.

1975 • 42 citations

Autoimmunity in thermal injury: occurrence of rheumatoid factors, antinuclear antibodies and antiepithelial antibodies.

1971 • 41 citations

CELL-MEDIATED IMMUNITY IN PATIENTS WITH MALIGNANT MELANOMA

1972 • 41 citations

Blocking Effect of Serum from Tumor-Bearing Animals on Macrophage Migration Inhibition with Tumor Antigens

1971 • 41 citations

Immune Alterations in Hodgkin's Disease

1973 • 40 citations

Cellular immunity in Wilms' tumour and neuroblastoma

1972 • 39 citations

Microphotometry in immunofluorescence.

1969 • 39 citations

Evaluation of Cell-Mediated Cytotoxic Reactivity against Tumor-Associated Antigens with 125I-Iododeoxyuridine-Labeled Target Cells

1974 • 39 citations

An examination of the immunology of cancer patients

1976 • 39 citations

POSTOPERATIVE IMMUNOSUPPRESSION IN PATIENTS WITH BREAST CANCER

1972 • 38 citations

The Role of the Mature Neutrophil in Bacterial Infections in Acute Leukemia

1957 • 36 citations

Mechanisms of target cell destruction by alloimmune peritoneal macrophages. II. Release of a specific cytotoxin from interacting cells.

1971 • 35 citations

Impaired Lymphocyte Response to Allogeneic Cultured Lymphoid Cells in Patients with Lung Cancer

1972 • 34 citations

Studies on the effect of macrophages in an in vitro graft reaction system.

1971 • 34 citations

Macrophage electrophoretic mobility (MEM) test in cancer: a critical evaluation.

1973 • 33 citations

Activation of Host Lymphocytes cultured with Cancer Cells treated with Neuraminidase

1971 • 33 citations

Indications of cellular immunological reactions against autochthonous tumour in cancer patients studied in vitro.

1968 • 32 citations

Specific Immunodiagnosis of Hepatocellular Carcinoma by Leucocyte Adherence Inhibition

1974 • 31 citations

Reticuloendothelial Phagocytic Function in Patients with Leukemia, Lymphoma and Multiple Myeloma

1965 • 31 citations

E and EAC rosetting lymphocytes in patients with carcinoma of bronchus. II. A sequential study of thirty patients: effect of BCG.

1975 • 30 citations

Antigenic Cross-Reactivity Between Benign and Malignant Neoplasms of the Human Breast 2

1974 • 29 citations

Surface immunoglobulins of leukaemic cells.

1973 • 29 citations

Circulating antibodies in human malignant disease.

1973 • 29 citations

The study of normal and malignant cell antigens by mixed agglutination.

1968 • 28 citations

¹⁴ C-Glucose Oxidation in Whole Blood: a Clinical Assay for Phagocyte Dysfunction

1972 • 28 citations

Formalinized tumour cells in the leucocyte migration inhibition test.

1975 • 28 citations

Leukocyte migration inhibition by cancer patients' sera

1976 • 27 citations

Cell Migration Inhibition in Human Lymphomas Using Lymph Node and Cell Line Antigens

1972 • 27 citations

Inhibition of antibody-dependent cell-mediated cytotoxicity (ADCC) as a means of detection of immune complexes in the sera of patients with thyroid disorders and bronchogenic carcinoma.

1976 • 27 citations

The dose-related effect of tumour extract on the in vitro migration of leucocytes from patients with renal carcinoma

1975 • 27 citations

Immunologic evidence suggesting a viral etiology of human osteosarcoma

1972 • 26 citations

Lymphocyte transformation in patients with Kaposi's sarcoma

1971 • 26 citations

Nitroblue Tetrazolium Reduction: False Positive and False Negative Results

1973 • 26 citations

Hexose monophosphate shunt activity of circulating phagocytes in acute lymphocytic leukemia.

1971 • 25 citations

Lymphocyte Transformation in Patients with Acute Lymphoblastic Leukaemia

1971 • 24 citations

Migration-Inhibiting Effect of Sera From Patients With Burkitt's Lymphoma 2

1973 • 23 citations

Human tumor—lymphocyte interaction in vitro: Blastogenesis correlated to detectable immunoglobulin in the biopsy

1975 • 23 citations

LYMPHOCYTE STIMULATION TEST FOR DETECTION OF TUMOR SPECIFIC REACTIVITY IN HUMANS

1976 • 22 citations

Levels of immunoglobulins in the serum of patients with carcinoma of the prostate.

1972 • 22 citations

Relation between Glucose Absorption Rate and Serum Globulin Concentration in Man

1973 • 21 citations

Cell‐mediated cytotoxicity to human pulmonary neoplasms

1975 • 19 citations

SENSITISATION OF NEUROBLASTOMA PATIENTS AND RELATED AND UNRELATED CONTACTS TO NEUROBLASTOMA EXTRACTS

1976 • 19 citations

7S Anti-tumour antibodies and activated Fc in macrophage tumour cell interaction

1973 • 19 citations

FORMALIN-FIXED TUMOUR CELLS IN THE LEUCOCYTE MIGRATION TEST

1973 • 18 citations

Quantitation of the microassay for cell-mediated immunity through electronic image analysis.

1973 • 18 citations

Studies with the macrophage migration inhibition (MMI) test in patients with malignant disease.

1975 • 18 citations

Organ Antibodies After Local Irradiation

1968 • 17 citations

Nitroblue tetrazolium dye reduction in various hematologic disorders.

1973 • 17 citations

Leukocytenadh�renz-Inhibitions-Test f�r cellul�r �bertragbare Immunit�t

1973 • 16 citations

Tumor-distinctive cellular immunity to human sarcoma and carcinoma.

1971 • 16 citations

Microcytotoxicity assays of tumor immunity in patients with bronchogenic carcinoma correlated with clinical status.

1975 • 13 citations

Syngeneic Immune Serum Specifically Inhibits the Motility of Tumour Cells

1973 • 13 citations

RESPONSE TO P.H.A. IN CANCER PATIENTS.

1973 • 13 citations

Transience of Immune Responses to Tumour Antigens in Man

1971 • 13 citations

Specific lymphocytotoxicity and blocking factors in tumours of the central nervous system.

1973 • 12 citations

Role of macrophages in immunity, with special reference to tumour immunology. A review.

1975 • 12 citations

Lymphocyte transformation in leukemic serum

1975 • 12 citations

Circulating antibodies in human connective tissue malignancy.

1973 • 12 citations

THE CAPILLARY TUBE LEUCOCYTE MIGRATION TECHNIQUE (LMT) AS A METHOD FOR DETECTION OF SERUM INHIBITING ACTIVITY OF TUMOUR‐DIRECTED, CELLULAR HYPERSENSITIVITY IN PATIENTS WITH RENAL CARCINOMAS

1974 • 11 citations

Tumor-directed cellular immunity in malignant melanoma and its modification by surgical treatment.

1973 • 11 citations

Immunoglobulins in Carcinoma of the Uterine Cervix

1972 • 10 citations

FUNCTION AND EVALUATION OF HUMAN K-CELLS

1976 • 10 citations

In vitro detection of cellular immunity to melanoma antigens in man by the monocyte spreading inhibition test

1976 • 9 citations

Immunological overshoot phenomenon following cancer chemotherapy: significance in prognosis evaluation of solid tumors.

1975 • 9 citations

Lymphocyte transformation in leukemic serum

1975 • 9 citations

New Method for the Rapid Quantitation of Immunofluorescence 2

1973 • 8 citations

Possible viral aetiology of human breast cancer

1973 • 7 citations

Effect of Immune Factors on the Motility of Lymphoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1972 • 7 citations

Lymphocyte sensitization in malignant neoplasia.

1972 • 6 citations

The mechanism of tumour cell induced inhibition of human leucocyte migration

1979 • 6 citations

Clinical tumour immunology

1985 • 5 citations

MECHANISMS OF TARGET CELL DESTRUCTION BY ALLOIMMUNE PERITONEAL MACROPHAGES11This study was supported in part by Grant CA12162 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

1976 • 3 citations

CELL-MEDIATED CYTOTOXICITY IN VITRO. MECHANISMS AND RELEVANCE TO TUMOR IMMUNITY

1976 • 2 citations

THE LEUCOCYTE MIGRATION TECHNIQUE IN STUDIES OF TUMOR-DIRECTED CELLULAR IMMUNITY IN MALIGNANT MELANOMA

1976 • 2 citations

In vitro study of cell-mediated immunity of patients with colorectal carcinoma.

1975 • 1 citations

Macrophage electrophoretic mobility test

1977 • 1 citations

Subpopulations of Lymphocytes: A Review

1975 • 1 citations