A yeast nuclear gene, MRS1, involved in mitochondrial RNA splicing: nucleotide sequence and mutational analysis of two overlapping open reading frames on opposite strands.

A new method for sequencing DNA.

1977 • 7,941 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

Codon selection in yeast.

1982 • 1,580 citations

Atlas of Protein Sequence and Structure, 1966.

1967 • 1,463 citations

Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes

1981 • 1,265 citations

DNA sequence required for efficient transcription termination in yeast

1982 • 1,014 citations

Trans-complementable copy-number mutants of plasmid ColE1

1980 • 975 citations

Isolation and characterisation of a yeast chromosomal replicator

1979 • 795 citations

The gapped duplex DNA approach to oligonucleotide-directed mutation construction

1984 • 511 citations

Conservation of RNA secondary structures in two intron families including mitochondrial-, chloroplast- and nuclear-encoded members.

1983 • 510 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron

1980 • 477 citations

The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

1986 • 464 citations

A self-splicing RNA excises an intron lariat

1986 • 449 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Excised group II introns in yeast mitochondria are lariats and can be formed by self-splicing in vitro

1986 • 346 citations

Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiae.

1985 • 325 citations

OVERLAPPING GENES

1983 • 225 citations

Achievements and perspectives of mitochondrial research

1985 • 210 citations

Self-splicing of group II introns in vitro: Mapping of the branch point and mutational inhibition of lariat formation

1986 • 197 citations

Assessment of a model for intron RNA secondary structure relevant to RNA self-splicing — a review

1984 • 190 citations

RNA splicing in neurospora mitochondria: Self-splicing of a mitochondrial intron in vitro

1984 • 187 citations

Assembly of the mitochondrial membrane system. Characterization of a yeast nuclear gene involved in the processing of the cytochrome b pre-mRNA.

1983 • 152 citations

Expression of the split gene cob in yeast: Evidence for a precursor of a “maturase” protein translated from intron 4 and preceding exons

1982 • 120 citations

The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans.

1984 • 111 citations

Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.

1983 • 97 citations

MSW, a yeast gene coding for mitochondrial tryptophanyl-tRNA synthetase.

1985 • 73 citations

A mutation in yeast mitochondrial DNA results in a precise excision of the terminal intron of the cytochrome b gene.

1985 • 64 citations

Expression of the "split gene" cob in yeast mtDNA. Nuclear mutations specifically block the excision of different introns from its primary transcript.

1983 • 62 citations

Determination of functional domains in intron bI1 of yeast mitochondrial RNA by studies of mitochondrial mutations and a nuclear suppressor.

1983 • 55 citations

Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae

1986 • 52 citations

Cloning of the yeast methionyl-tRNA synthetase gene.

1981 • 42 citations

Genetic system for analyzing Escherichia coli thymidylate synthase

1984 • 41 citations

The primary structure of Lactobacillus casei thymidylate synthetase. II. The complete amino acid sequence of the active site peptide, CNBr 4.

1979 • 41 citations

Coding capacity of complementary DNA strands

1981 • 26 citations

A collection of programs for nucleic acid and protein analysis, written in FORTRAN 77 for IBM-PC compatible microcomputers

1986 • 23 citations