Neuronal Glutamate Uptake Contributes to GABA Synthesis and Inhibitory Synaptic Strength

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Glutamate uptake

2001 • 3,867 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1

1997 • 1,715 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

Glutamine Synthetase: Glial Localization in Brain

1977 • 1,170 citations

Definition of the Readily Releasable Pool of Vesicles at Hippocampal Synapses

1996 • 1,088 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain

1993 • 892 citations

Interneurons unbound

2001 • 557 citations

dl-threo-β-Benzyloxyaspartate, A Potent Blocker of Excitatory Amino Acid Transporters

1998 • 545 citations

Two components of transmitter release at a central synapse.

1994 • 528 citations

Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes

1997 • 511 citations

Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude

1997 • 453 citations

Astrocytes: Glutamate producers for neurons

1999 • 438 citations

Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake

1997 • 425 citations

Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1995 • 354 citations

Kainate Receptors Presynaptically Downregulate GABAergic Inhibition in the Rat Hippocampus

1997 • 318 citations

Presynaptic Recording of Quanta from Midbrain Dopamine Neurons and Modulation of the Quantal Size

1998 • 313 citations

Macroscopic and Microscopic Properties of a Cloned Glutamate Transporter/Chloride Channel

1998 • 279 citations

Cooperation between independent hippocampal synapses is controlled by glutamate uptake

2002 • 256 citations

A Neuronal Glutamate Transporter Contributes to Neurotransmitter GABA Synthesis and Epilepsy

2002 • 256 citations

Neuronal Glutamate Transporters Limit Activation of NMDA Receptors by Neurotransmitter Spillover on CA1 Pyramidal Cells

2001 • 256 citations

Glutamate spillover suppresses inhibition by activating presynaptic mGluRs

2000 • 246 citations

Prolonged Synaptic Currents and Glutamate Spillover at the Parallel Fiber to Stellate Cell Synapse

2000 • 229 citations

EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex

1998 • 225 citations

Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

2001 • 222 citations

Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones

2000 • 211 citations

Variation in GABA mini amplitude is the consequence of variation in transmitter concentration

1995 • 211 citations

Glutamine Uptake by Neurons: Interaction of Protons with System A Transporters

2002 • 205 citations

Expression of a Variant Form of the Glutamate Transporter GLT1 in Neuronal Cultures and in Neurons and Astrocytes in the Rat Brain

2002 • 205 citations

Neuronal Glutamate Transporters Control Activation of Postsynaptic Metabotropic Glutamate Receptors and Influence Cerebellar Long-Term Depression

2001 • 202 citations

Glutamine from Glial Cells Is Essential for the Maintenance of the Nerve Terminal Pool of Glutamate: Immunogold Evidence from Hippocampal Slice Cultures

1995 • 189 citations

The role of the synthetic enzyme GAD65 in the control of neuronal γ-aminobutyric acid release

1999 • 188 citations

Expression of a Putative Vesicular Acetylcholine Transporter Facilitates Quantal Transmitter Packaging

1997 • 174 citations

Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex

2001 • 174 citations

Synaptically Released Glutamate Does Not Overwhelm Transporters on Hippocampal Astrocytes During High-Frequency Stimulation

2000 • 154 citations

Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit gluR2 in the rat hippocampus

2000 • 152 citations

Cell type‐ and synapse‐specific variability in synaptic GABA_A receptor occupancy

2000 • 146 citations

Demonstration of glutamate/aspartate uptake activity in nerve endings by use of antibodies recognizing exogenous d-aspartate

1993 • 138 citations

MERCAPTOPROPIONIC ACID: A CONVULSANT THAT INHIBITS GLUTAMATE DECARBOXYLASE¹

1970 • 118 citations

GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase

1999 • 116 citations

Plasticity of rat central inhibitory synapses through GABA metabolism

2001 • 103 citations

Patch-Pipette Recordings from the Soma, Dendrites, and Axon of Neurons in Brain Slices

1995 • 92 citations

Alteration of Striatal Glutamate Release After Glutamine Synthetase Inhibition

1984 • 84 citations

Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-d-aspartate receptors in the rat hippocampus

1999 • 80 citations

Laminar difference in GABA uptake and GAT‐1 expression in rat CA1

1998 • 73 citations

Glutamate Uptake Controls Expression of a Slow Postsynaptic Current Mediated by mGluRs in Cerebellar Purkinje Cells

2002 • 65 citations

Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells

1994 • 63 citations

How Does a Vesicle Know It Is Full?

1997 • 60 citations

Glutamate-synthesizing enzymes in gabaergic neurons of the neocortex: A double immunofluorescence study in the rat

1994 • 56 citations

Altering the concentration of GABA in the synaptic cleft potentiates miniature IPSCs in rat occipital cortex

2000 • 44 citations

Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.

1992 • 33 citations

Effects of dihydrokainic acid of extracellular amino acids and neuronal excitability in the in vivo rat hippocampus

1987 • 32 citations

Heterologous modulation of inhibitory synaptic transmission by metabotropic glutamate receptors in cultured hippocampal neurons

1996 • 31 citations

Recycling and refilling of transmitter quanta at the frog neuromuscular junction

2000 • 27 citations

Inactivation of cerebral glutamine synthetase by dl-methionine-dl-sulfoximine

1967 • 25 citations