Relation of Brain Serotonin to the Inhibition and Enhancement of Morphine Tolerance and Physical Dependence

p-Chlorophenylalanine: a specific depletor of brain serotonin.

1966 • 1,754 citations

Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels

1971 • 1,006 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

Serotonin and Behavior

1973 • 543 citations

APPLICATION OF STEADY STATE KINETICS TO THE SYNTHESIS RATE AND TURNOVER TIME OF SEROTONIN IN THE BRAIN OF NORMAL AND RESERPINE-TREATED RATS

1966 • 311 citations

Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.

1967 • 308 citations

Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine

1968 • 259 citations

Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine.

1971 • 241 citations

Modification of Morphine Withdrawal by Drugs interacting with Humoral Mechanisms: Some Contradictions and their Interpretation

1972 • 233 citations

A simple procedure for calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.

1971 • 183 citations

The addiction cycle to narcotics in the rat and its relation to catecholamines

1968 • 151 citations

Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide

1969 • 116 citations

Neuroanatomical Correlates of Morphine Dependence

1972 • 94 citations

Parachlorophenylalanine - its three phase sequence of interactions with the two forms of brain tryptophan hydroxylase

1972 • 92 citations

Brain serotonin turnover in morphine tolerant and dependent mice.

1970 • 85 citations

Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.

1972 • 79 citations

Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.

1971 • 70 citations

Evidence against a role of brain 5-hydroxytryptamine in the development of physical dependence upon morphine in mice.

1971 • 67 citations

Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain

1971 • 64 citations

The effect of p-chlorophenylalanine on opiate-induced running, analgesia, tolerance and physical dependence in mice.

1971 • 63 citations

Physical dependence on morphine fails to increase serotonin turnover rate in rat brain

1971 • 62 citations

A simple method for producing tolerance to dihydromorphinone in mice.

1963 • 48 citations

Role of biogenic amines in morphine dependence in the rat

1970 • 43 citations

STIMULATION OF BRAIN SEROTONIN SYNTHESIS BY DIBUTYRYL‐CYCLIC AMP IN RATS

1971 • 40 citations

Influence of L-tryptophan on morphine analgesia, tolerance and physical dependence.

1975 • 38 citations

Methadone increases Mouse Brain 5-Hydroxyindoleacetic Acid

1971 • 36 citations

REGULATION OF HEPATIC ENZYME SYNTHESIS BY CYCLIC AMP*

1971 • 26 citations

Trytophan hydroxylase changes in midbrain of the rat after chronic morphine administration

1970 • 20 citations

Dissociation of morphine tolerance and dependence from brain serotonin synthesis rate in mice

1972 • 20 citations

Some Macromolecular Mechanisms in CNS Neurotransmitter Pharmacology and Their Psychobiological Organization

1972 • 13 citations

Narcotic Tolerance and Dependence and Serotonin Turnover

1972 • 6 citations