The Use of Single Nephron Techniques in Renal Toxicity Studies

Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation

1981 • 1,664 citations

Cyclosporine-Associated Chronic Nephropathy

1984 • 1,174 citations

Handbook of Physiology. Section- 2

1967 • 520 citations

Reviews in biochemical toxicology

1979 • 518 citations

Ischemic damage and repair in the rat proximal tubule: Differences among the S1, S2, and S3 segments

1978 • 490 citations

Enzyme distribution along the nephron

1984 • 490 citations

Handbook of Experimental Pharmacology, vol 14.

1972 • 446 citations

Effect of cyclosporine administration on renal hemodynamics in conscious rats

1985 • 416 citations

Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.

1976 • 414 citations

The Dynamics of Glomerular Ultrafiltration in the Rat

1971 • 395 citations

Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat.

1975 • 336 citations

Sites of hormone action in the mammalian nephron

1981 • 306 citations

Hemodynamically Mediated Acute Renal Failure

1986 • 303 citations

Familial hypothalamic diabetes insipidus in rats (Brattleboro strain)

1964 • 296 citations

Tubular leakage and obstruction after renal ischemia: Structural-functional correlations

1978 • 290 citations

Reviews in biochemical toxicology

1979 • 274 citations

Renal substrate metabolism.

1986 • 235 citations

OCCURRENCE OF OCHRATOXIN A AND CITRININ IN CEREALS ASSOCIATED WITH MYCOTOXIC PORCINE NEPHROPATHY

1973 • 225 citations

The mechanism of acute renal failure after uranyl nitrate.

1975 • 223 citations

Renal necrosis, glutathione depletion, and covalent binding after acetaminophen

1978 • 222 citations

Hormonal control of kidney functions at the cell level.

1986 • 206 citations

Pathogenesis of acute renal failure following temporary renal ischemia in the rat.

1975 • 206 citations

Glycerol-induced hemoglobinuric acute renal failure in the rat. I. Micropuncture study of the development of oliguria.

1966 • 201 citations

Characteristics of p-aminohippurate transport in proximal renal tubules

1969 • 196 citations

Current concepts on the pathophysiology of acute renal failure

1978 • 191 citations

PTH sensitive adenyl cyclase activity in different segments of the rabbit nephron

1975 • 184 citations

Transport of p-aminohippuric acid by plasma membrane vesicles isolated from rat kidney cortex

1976 • 183 citations

Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats.

1985 • 179 citations

Pathophysiology of altered glomerular function in aminoglycoside-treated rats

1981 • 178 citations

Hormonal modulation of glomerular function

1983 • 172 citations

Mechanisms of the defect in glomerular ultrafiltration associated with gentamicin administration

1977 • 172 citations

Renal Micropuncture Study of the Development of Anuria in the Rat with Mercury-induced Acute Renal Failure*

1965 • 169 citations

Adenylate cyclase responsiveness to hormones in various portions of the human nephron.

1980 • 161 citations

Renal tubule transport of organic cations

1981 • 156 citations

The Role of “Leakage” of Tubular Fluid in Anuria Due to Mercury Poisoning*

1967 • 156 citations

A study by micropuncture and microdissection of acute renal damage in rats

1968 • 154 citations

Glycerol Induced Hemoglobinuric Acute Renal Failure in the Rat

1967 • 153 citations

Micropuncture study of water, electrolytes, and urea movements along the loops of henle in psammomys

1969 • 150 citations

Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy.

1977 • 150 citations

Epithelial ion and water transport

1982 • 133 citations

Pharmacology of pyrazinamide: metabolic and renal function studies related to the mechanism of drug-induced urate retention.

1972 • 131 citations

Metabolic fuels along the nephron: Pathways and intracellular mechanisms of interaction

1986 • 130 citations

Vasopressin dependent adenylate cyclase in single segments of rabbit kidney tubule

1975 • 129 citations

A micropuncture study of the renal handling of lithium

1979 • 129 citations

Effects of renal artery occlusion on kidney function in the rat

1973 • 128 citations

Feedback control of glomerular blood flow, pressure, and filtration rate

1979 • 124 citations

Cis-diamminedichlorplatinum-induced acute renal failure in the rat

1982 • 122 citations

Adenylate cyclase activity along the rabbit nephron as measured in single isolated segments

1975 • 121 citations

Relationship between Para-aminohippurate Secretion and Cellular Morphology in Rabbit Proximal Tubules

1978 • 119 citations

Micropuncture study of nephron function in the rhesus monkey

1968 • 118 citations

Pathophysiology of a nephrotoxic model of acute renal failure

1975 • 116 citations

Distribution of calcitonin-sensitive adenylate cyclase activity along the rabbit kidney tubule.

1976 • 111 citations

Cisplatin nephrotoxicity in rats: defect in papillary hypertonicity

1981 • 104 citations

Toxicology of the kidney

1993 • 104 citations

Localization of active and inactive kallikrein (kininogenase activity) in the microdissected rabbit nephron

1982 • 101 citations

Solute and water flows in thin limbs of Henle's loop in the hamster kidney

1970 • 101 citations

The early phase of experimental acute renal failure

1981 • 95 citations

Mechanisms of cephalosporin nephrotoxicity: A comparison of cephaloridine and cephaloglycin

1980 • 95 citations

Ischemia and tubule obstruction during acute renal failure in dogs: mannitol in protection

1980 • 94 citations

Amphotericin B nephrotoxicity: Increased renal resistance and tubule permeability

1982 • 92 citations

Renal tubular transport of gentamicin in the rat

1979 • 92 citations

Uranyl nitrate-induced acute renal failure in the rat: Micropuncture and renal hemodynamic studies

1974 • 91 citations

Metabolic oxidation of acetaminophen (Paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney

1981 • 90 citations

Organization of nephron function

1983 • 90 citations

Substrate oxidation by isolated single nephron segments of the rat

1981 • 88 citations

Prior mannitol and furosemide infusion in a model of ischemic acute renal failure

1981 • 87 citations

Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione.

1978 • 85 citations

Gentamicin incorporation along the nephron: Autoradiographic study on isolated tubules

1981 • 83 citations

Kidney pressures after temporary renal artery occlusion in the rat

1976 • 82 citations

Specificity and modes of the anion exchanger in dog renal microvillus membranes

1983 • 82 citations

Vanadate-stimulated natriuresis

1978 • 82 citations

Nephrotoxic acute renal failure due to common drugs

1981 • 82 citations

Mechanisms in the development of analgesic nephropathy

1980 • 80 citations

Catecholamine sensitive adenylate cyclase activity in different segments of the rabbit nephron

1975 • 80 citations

High-affinity Ca-Mg-ATPase along the rabbit nephron

1982 • 76 citations

Interrelationships among quinidine, amiloride, and lithium as inhibitors of the renal Na+-H+ exchanger.

1985 • 75 citations

Functional segmentation of the mammalian nephron

1981 • 75 citations

Concentration-dependent sodium chloride transport as the signal in feedback control of glomerular filtration rate.

1982 • 75 citations

Amino Acid Transport and Uric Acid Transport

1977 • 75 citations

Nephrotoxic Mechanisms of Drugs and Environmental Toxins

1982 • 74 citations

Methemoglobin-Induced Acute Renal Failure in the Rat

1967 • 74 citations

Mineralcorticoid receptors along the nephron: [3H]aldosterone binding in rabbit tubules

1981 • 74 citations

Studies on the pathogenesis of cisplatin-induced hypomagnesemia in rats

1985 • 74 citations

Micropuncture Study of Renal Tubular Factors in Low Dose Mercury Poisoning

1971 • 72 citations

Distribution and function of classes of ATPases along the nephron

1986 • 70 citations

Membrane permeability as a cause of transport defects in experimental Fanconi syndrome. A new hypothesis.

1976 • 69 citations

The distal nephron of rat kidney: a target site for glucagon.

1980 • 68 citations

Prostaglandin endoperoxide synthetase-dependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes.

1981 • 67 citations

Evidence for differences in the sensitivity to ouabain of NaK-ATPase along the nephrons of rabbit kidney.

1986 • 66 citations

The early phase of experimental acute renal failure

1977 • 65 citations

Inhibition of Renal Metabolism. Relative effects of arsenate on sodium, phosphate, and glucose transport by the rabbit proximal tubule.

1980 • 64 citations

Micropuncture study of urea transport in rat renal medulla

1966 • 63 citations

Secretion of tetraethylammonium by proximal tubules of rabbit kidneys

1983 • 62 citations

A micropuncture study of the early phase of acute urate nephropathy.

1976 • 61 citations

Disparity between surface and deep nephron function early after renal ischemia

1983 • 61 citations

METHODS OF COLLECTING FLUID FROM KNOWN REGIONS OF THE RENAL TUBULES OF AMPHIBIA AND OF PERFUSING THE LUMEN OF A SINGLE TUBULE

1936 • 60 citations

Isolated nephron segments in a rabbit model of ischemic acute renal failure

1980 • 58 citations

Lead intoxication during development: Its late effects on kidney function and blood pressure

1980 • 58 citations

The early phase of experimental acute renal failure. III. Tubuloglomerular feedback

1978 • 58 citations

A functional role for the tubuloglomerular feedback mechanism

1984 • 58 citations

Pathophysiology of acute Bence-Jones protein nephrotoxicity in the rat

1981 • 57 citations

Urinary Excretion of Uric Acid in Nonhuman Mammalian Species

1978 • 57 citations

Urate transport in the nephron

1979 • 57 citations

Alpha2-adrenoceptors and cellular cAMP levels in single nephron segments from the rat

1985 • 57 citations

Alterations of renal function during dietary-induced hyperuricemia in the rat

1976 • 56 citations

Renal Pathophysiology.

1981 • 53 citations

A study by microdissection and micropuncture of the structure and the function of the kidneys and the nephrons of rats with chronic renal damage

1974 • 53 citations

Aldosterone binding in isolated tubules. III. Autoradiography along the rat nephron

1983 • 53 citations

Role of tubular obstruction in acute renal failure due to gentamicin

1983 • 53 citations

CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION

1983 • 53 citations

Micropuncture Techniques and Nephron Function.

1969 • 52 citations

Dynamics of glomerular ultrafiltration: VI. Studies in the primate

1974 • 50 citations

Metabolism and sites of action of vitamin D in the kidney

1986 • 49 citations

Glucagon receptors along the nephron: [125I]glucagon binding in rat tubules

1985 • 49 citations

Urate transport in the proximal tubule: in vivo and vesicle studies

1985 • 49 citations

Vasopressin-prostaglandin interactions in isolated tubules from rat outer medulla.

1980 • 48 citations

Cimetidine secretion by rabbit renal tubules in vitro

1981 • 47 citations

Nephrotoxicity of cyclosporin A. A lithium clearance and micropuncture study in rats

1986 • 46 citations

Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell interactions to determinants linked together: suppression vs. enhancement.

1975 • 46 citations

Effects of lithium on the kidney

1980 • 46 citations

A method for exposing the rat renal medulla in vivo: micropuncture of the collecting duct

1965 • 45 citations

The early phase of experimental acute renal failure

1979 • 45 citations

Inhibition by lithium of the hydroosmotic action of vasopressin in the isolated perfused cortical collecting tubule of the rabbit.

1986 • 45 citations

Measurements of Glomerular Dynamics

1978 • 44 citations

Metabolism of acetaminophen by the isolated perfused kidney.

1982 • 43 citations

The early phase of experimental acute renal failure

1977 • 43 citations

Cimetidine and procainamide secretion by proximal tubules in vitro

1982 • 43 citations

Early functional and morphological changes in renal tubular necrosis due top-aminophenol

1983 • 41 citations

Effects of thyroid hormone on Na-K-adenosine triphosphatase activity along the rat nephron.

1985 • 40 citations

Manual of renal micropuncture

1978 • 40 citations

Micropuncture study of the handling of gentamicin by the rat kidney

1981 • 39 citations

NEPHROTOXICITY OF CYCLOSPORIN A

1981 • 39 citations

Maleic acid induced aminoaciduria, studied by free flow micropuncture and continuous microperfusion

1979 • 39 citations

Heterogeneity of organic base secretion by proximal tubules

1982 • 37 citations

Lithium-Induced Polyuria: Effect of Lithium on Adenylate Cyclase and Adenosine 3′,5′-Monophosphate Phosphodiesterase in Medullary Ascending Limb of Henle's Loop and in Medullary Collecting Tubules*

1980 • 36 citations

Gentamicin-Induced Acute Renal Failure in the Rat

1981 • 36 citations

Transport and metabolism of [3H]morphine in isolated, nonperfused proximal tubular segments of the rabbit kidney.

1982 • 35 citations

Mechanisms of lysine-induced acute renal failure in rats

1985 • 35 citations

Microinjections of L-Leucine into Tubules and Peritubular Capillaries of the Rat

1971 • 35 citations

Biochemical mechanisms of nephrotoxicity.

1985 • 34 citations

Electrophysiology of Mammalian Renal Tubules: Inferences from Intracellular Microelectrode Studies

1983 • 33 citations

Bidirectional renal tubular transport of free choline: a micropuncture study

1979 • 33 citations

Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney

1978 • 33 citations

Reduction of renal blood flow and proximal bicarbonate reabsorption in rats by gentamicin

1983 • 32 citations

A study in vitro of the concentrating defect associated with hypokalaemia and hypercalcaemia

1976 • 31 citations

Autoradiographic determination of dexamethasone binding sites along the rabbit nephron

1983 • 31 citations

Distribution of Glomeruli in the Renal Cortex of Munich Wistar Frömter (MWF) Rats

1983 • 31 citations

The measurement of nephron filtration rate and absolute reabsorption in the proximal tubule of the rabbit kidney.

1975 • 30 citations

Renal tubular transport and metabolism of organic cations by the rabbit

1981 • 30 citations

Epithelial ion and water transport

1981 • 29 citations

Superficial Nephron Obstruction and Medullary Congestion after Ischemic Injury: Effect of Protective Treatments

1982 • 28 citations

Distal tubule [Na+] and juxtaglomerular apparatus renin activity in uranyl nitrate induced acute renal failure in the rat

1976 • 28 citations

Single tubule perfusion techniques

1986 • 27 citations

Renal handling of aluminum in the rat: clearance and micropuncture studies

1985 • 27 citations

Micropuncture study of tubular transport of urate and PAH in the pig kidney

1980 • 26 citations

Nephron heterogeneity in ischemic acute renal failure

1984 • 25 citations

Renal excretion of N'1-methylnicotinamide in the rat

1975 • 22 citations

Acute renal failure : correlations between morphology and function

1984 • 22 citations

Verapamil and quinidine effects on PAH transport by isolated perfused renal tubules

1984 • 21 citations

Electrochemical Profile for Ion Transport across the Membrane of Proximal Tubular Cells

1980 • 20 citations

Microperfusion of Isolated Tubules

1978 • 19 citations

Distribution of alpha-adrenergic receptors in the rabbit nephron.

1984 • 19 citations

Therapy of Cryptococcosis with a Combination of Flucytosine and Amphotericin B

1975 • 18 citations

Effect of gentamicin on isolated glomeruli and proximal tubules of the rabbit.

1985 • 18 citations

Role of volume depletion in the glycerol model of acute renal failure

1986 • 18 citations

Effects of low [Ca2+] and La3+ on PAH transport by isolated perfused renal tubules

1984 • 17 citations

Renal transport of netilmicin in the rat.

1984 • 17 citations

Effect of cyclosporine on the diluting capacity of the rat kidney.

1986 • 17 citations

Study of Renal Action of Diuretics by Micropuncture Techniques

1976 • 17 citations

Dissociation of glomerular filtration and renal blood flow in HgCl2-induced acute renal failure

1982 • 16 citations

Electrophysiological Measurements on the Renal Tubule

1978 • 16 citations

Accumulation of [14C]urate and [3H]PAH in isolated proximal tubular segments of the rabbit kidney

1980 • 16 citations

The electrophysiological analysis of tubular transport

1986 • 16 citations

Salicylate excretion in the rat; free flow micropuncture experiments.

1978 • 16 citations

An Evaluation of the Role of Tubular Obstruction in Folic Acid-Induced Acute Renal Failure in the Rat

1978 • 16 citations

Tubuloglomerular feedback after nephron or ureteral obstruction

1985 • 15 citations

Effects of p-aminohippurate and pyrazinoate on the renal excretion of salicylate in the rat: a micropuncture study.

1983 • 15 citations

Uptake of [3H]PAH and [14C]urate into isolated proximal tubular segments of the pig kidney

1981 • 15 citations

Regulation of renal cellular cAMP levels by prostaglandins and α2-adrenoceptors: Microdissection studies

1986 • 15 citations

Effects of sodium orthovanadate on whole kidney and single nephron function

1980 • 14 citations

Renal Handling of Cadmium: A Study by Tubular Microinjections

1984 • 14 citations

Renal handling of gentamicin by the Munich-Wistar rat

1981 • 14 citations

Evidence for renal tubular leakage in maleic acid-induced Fanconi syndrome

1980 • 13 citations

Effect of cisplatin on the transepithelial potential difference of rat distal tubule

1985 • 13 citations

A micropuncture study of urate excretion byCebus monkeys employing high performance liquid chromatography with amperometric detection of urate

1980 • 13 citations

Proximal tubular HCO 3 − , H+ and fluid transport during maleate-induced acidification defect

1984 • 13 citations

Cortical and papillary absorptive defects in gentamicin nephrotoxicity

1983 • 12 citations

Micropuncture techniques

1986 • 12 citations

Maleic acid-induced reabsorptive dysfunction in the proximal and distal nephron

1983 • 11 citations

Glomerular filtration and tubular reabsorption during anuria in postischemic acute renal failure

1984 • 11 citations

Effect of Lithium Treatment on Rat Renal Tubule Function

1980 • 11 citations

Microperfusion study of proximal tubule bicarbonate transport in maleic acid-induced renal tubular acidosis

1986 • 10 citations

Amphiuma Kidney as a Model for Distal Tubular Transport Studies1

2015 • 10 citations

Dependence of water movement on sodium transport in kidney proximal tubule: A microperfusion study substituting lithium for sodium

1981 • 8 citations

Ultrafiltration of gentamicin and netilmicin in vivo.

1982 • 8 citations

Pyrazinoate transport in the isolated perfused rabbit proximal tubule

1986 • 8 citations

Intratubular microinjection study of gentamicin transport in the rat.

1983 • 8 citations

Micropuncture Study of the Superficial Nephron of <i>Cercopithecus aethiops</i>

1986 • 8 citations

Effects of Sulfhydryl Reagent, <i>p</i>-Chloromercuribenzoate, on <i>p</i>-Aminohippurate Transport by Isolated, Perfused Snake Renal Tubules

1983 • 7 citations

Glucose transport in chronically altered rat nephrons

1982 • 7 citations

Effect of vanadate on fluid absorption and PAH secretion in isolated proximal tubules

1983 • 7 citations

Micropuncture Techniques as a Tool in Renal Pharmacology

1979 • 7 citations

Effect of cyclosporine A on renal electrolyte transport: whole kidney and Henle loop study.

1986 • 7 citations

Initial remarks and acknowledgments: Isolated perfused tubule symposium

1982 • 6 citations

Renal tubular handling of 203Hg2+ in the dog: A microinjection study

1980 • 6 citations

The Use of the Isolated Tubule Preparation for the Investigation of Diuretics

1976 • 6 citations

[Na-K]ATPase activity in proximal and distal tubules of the rat kidney: Modification and application of a quantitative cytochemical technique

1985 • 5 citations

Studies on acute disease models

1982 • 5 citations

Effect of lithium treatment on rat renal tubule function. Evidence against impaired antidiuretic hormone action.

1980 • 5 citations

Micropuncture study of fluid handling in the cat kidney

1977 • 4 citations

Nephrotoxicity of ciclosporin

1986 • 4 citations

Inhibition of vasopressin action by vanadate in the cortical collecting tubule

1983 • 4 citations

HgCl<sub>2</sub>-Induced Acute Renal Failure Studied by Split Drop Micropuncture Technique in the Rat

1978 • 4 citations

Use of isolated single nephron segments to study metabolic heterogeneity of the nephron.

1983 • 4 citations

Mechanisms involved in the reabsorption of salicylate in the proximal tubule of rabbits.

1984 • 2 citations

Tubuloglomerular feedback in the rat initiated by serum activity in patients with acute renal failure.

1982 • 2 citations

Effect of Heavy Metals on Sodium Transport in Vitro

1982 • 2 citations

Glaphenine-induced acute renal failure in the rat: a new experimental model

1982 • 2 citations

Heavy Metal Models of Experimental Acute Renal Failure

1982 • 2 citations

A Micropuncture Study of a Dietary Induced, Hyperuricemic Model of Acute Renal Failure in the Rat

1980 • 2 citations

Deleted Work

1955 • 0 citations