Analysis of DNA Repair Using Transfection-Based Host Cell Reactivation

Experiments in molecular genetics

1972 • 28,260 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

RESPONSE Re: Markers of DNA Repair and Susceptibility to Cancer in Humans: an Epidemiologic Review

2000 • 556 citations

Markers of DNA Repair and Susceptibility to Cancer in Humans: an Epidemiologic Review

2000 • 496 citations

Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells.

2002 • 346 citations

Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells

2000 • 344 citations

Development and field-test validation of an assay for DNA repair in circulating human lymphocytes.

1991 • 194 citations

One pyrimidine dimer inactivates expression of a transfected gene in xeroderma pigmentosum cells.

1985 • 189 citations

Reduced DNA repair capacity in head and neck cancer patients.

1998 • 188 citations

Reactivation After Photobiological Damage

1966 • 136 citations

Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation.

1998 • 120 citations

Repair synthesis by human cell extracts in DNA damaged bycis- andtrans-diamminedichloroplatinum(II)

1989 • 113 citations

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5

1979 • 74 citations

Alterations of DNA Repair in Melanoma Cell Lines Resistant to Cisplatin, Fotemustine, or Etoposide

2000 • 58 citations

Expression in normal human tissues of five nucleotide excision repair genes measured simultaneously by multiplex reverse transcription-polymerase chain reaction.

1999 • 57 citations

Reduced global genomic repair of ultraviolet light-induced cyclobutane pyrimidine dimers in simian virus 40-transformed human cells

2000 • 54 citations

Repair of sulfur mustard-induced DNA damage in mammalian cells measured by a host cell reactivation assay

2001 • 40 citations

A Novel Host Cell Reactivation Assay to Assess Homologous Recombination Capacity in Human Cancer Cell Lines

2001 • 39 citations

Enhanced host cell reactivation capacity and expression of DNA repair genes in human breast cancer cells resistant to bi-functional alkylating agents

1995 • 38 citations

Host cell reactivation by human cells of DNA expression vectors damaged by ultraviolet radiation or by acid-heat treatment

1986 • 29 citations

Reactivation of psoralen-reacted plasmid DNA in Fanconi anemia, xeroderma pigmentosum, and normal human fibroblast cells

1991 • 22 citations

Unique tissue-specific level of DNA nucleotide excision repair in primary human mammary epithelial cultures

2003 • 22 citations

Processing of three different types of DNA damage in cell lines of a cutaneous squamous cell carcinoma progression model

1997 • 21 citations

Exposure chamber for quantitative ultraviolet photobiology.

1969 • 20 citations

Equilibrium and Stop-Flow Kinetic Studies of Fluorescently Labeled DNA Substrates with DNA Repair Proteins XPA and Replication Protein A

2001 • 19 citations

Relationships among cell survival, O6-alkylguanine-DNA alkyltransferase activity, and reactivation of methylated adenovirus 5 and herpes simplex virus type 1 in human melanoma cell lines.

1989 • 18 citations

Elevated DNA Excision Repair Capacity in the Extraembryonic Mesoderm of the Midgestation Mouse Embryo

1996 • 17 citations

Base Excision Repair Assay Using Xenopus laevisOocyte Extracts

2003 • 15 citations

Construction and purification of site-specifically modified DNA templates for transcription assays

2003 • 14 citations

Reparable lethal DNA damage produced by enzyme-activated 4-hydroxyaminoquinoline 1-oxide

1975 • 14 citations

Inactivation by nitrogen mustard of plasmids introduced into normal and Fanconi's anaemia cells

1988 • 12 citations

Repair of DNA lesions induced by ultraviolet irradiation and aromatic amines in normal and repair-deficient human lymphoblastoid cell lines

1995 • 10 citations

Host cell reactivation of ozone-treated T3 bacteriophage by different strains ofEscherichia coli

1982 • 6 citations

Host-Cell Reactivation of Irradiated Human Adenovirus

1975 • 3 citations