Development and reversion of methionine dependence in a human glioma cell line: relation to homocysteine remethylation and cobalamin status.

Methionine metabolism in mammals

1990 • 1,463 citations

Homocysteine and other thiols in plasma and urine: automated determination and sample stability

1993 • 480 citations

Cancer as a dynamic developmental disorder.

1985 • 216 citations

Fully automated fluorescence assay for determining total homocysteine in plasma.

1989 • 208 citations

Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.

1985 • 159 citations

Glioma cell interactions with fetal rat brain aggregates in vitro and with brain tissue in vivo.

1986 • 131 citations

Expression of the biochemical defect of methionine dependence in fresh patient tumors in primary histoculture.

1993 • 116 citations

Methionine Dependency of Malignant Tumors: A Possible Approach for Therapy

1990 • 109 citations

Altered methionine metabolism and transmethylation in cancer.

1985 • 104 citations

Measurements of S-adenosylmethionine and L-homocysteine metabolism in cultured human lymphoid cells.

1983 • 100 citations

Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells.

1989 • 84 citations

Genetic heterogeneity among patients with methylcobalamin deficiency. Definition of two complementation groups, cblE and cblG.

1988 • 84 citations

Characteristics of human and rat glioma cells grown in a defined medium.

1988 • 78 citations

N5-methyltetrahydrofolate: Homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells

1974 • 70 citations

Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers.

1993 • 54 citations

Effect of methionine deprivation on methylation and synthesis of macromolecules

1980 • 54 citations

Inherited disorders of vitamin B₁₂ utilization

1990 • 52 citations

Cobalamin Binding and Cobalamin-Dependent Enzyme Activity in Normal and Mutant Human Fibroblasts

1978 • 52 citations

Glial cells as a model for the role of cobalamin in the nervous system: Impaired synthesis of cobalamin coenzymes in cultured human astrocytes following short-term cobalamin-deprivation

1992 • 43 citations

Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates.

1992 • 37 citations

Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism.

1986 • 26 citations

Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture.

1991 • 26 citations

Salvage of 5′-deoxy-5′-methylthioadenosine and L-homocysteine into methionine in cells cultured in a methionine-free medium: A study of “methionine-dependence”

1986 • 22 citations

Effect of Methionine and Nitrous Oxide on Homocysteine Export and Remethylation in Fibroblasts from Cystathionine Synthase-Deficient, cblG, and cblE Patients

1994 • 20 citations

Growth support and toxicity of homocysteine and its effects on methionine metabolism in non-transformed and chemically transformed C3H/10T1/2 cells

1988 • 13 citations

Spontaneous and 5-azacytidine-induced revertants of methionine-dependent tumor-derived and H-ras-1-transformed cells

1989 • 11 citations

Observations on the intracellular accumulation of methotrexate and 5-methyltetrahydrofolate in uninduced, dimethylsulphoxide-induced and 1,25-dihydroxyvitamin D3-induced HL60 cells, and blood-monocyte-derived human macrophages

1988 • 5 citations