Metabolism of leukotriene B4 by activated human polymorphonuclear granulocytes.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

Ecto-Enzymes of the Guinea Pig Polymorphonuclear Leukocyte

1974 • 378 citations

Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B₄ from human leukocytes

1981 • 313 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Specific binding of leukotriene B4 to receptors on human polymorphonuclear leukocytes.

1982 • 263 citations

Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.

1983 • 225 citations

The role of phosphoinositiees in signal transduction

1986 • 225 citations

THE PHARMACOLOGY AND PATHOPHYSIOLOGY OF LEUKOTRIENE B4

1983 • 182 citations

Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes

1981 • 165 citations

Endogenous protein phosphorylation by resting and activated human neutrophils

1983 • 143 citations

Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.

1985 • 130 citations

Leukotrienes as mediators of ischemia and shock

1986 • 113 citations

Mechanism of phorbol diester-induced regulation of surface transferrin receptor involves the action of activated protein kinase C and an intact cytoskeleton.

1985 • 111 citations

Leukotriene B4 binding to human neutrophils

1984 • 93 citations

Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite.

1986 • 82 citations

Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils.

1987 • 77 citations

Cyclic AMP inhibition of phosphoinositide turnover in human neutrophils

1986 • 77 citations

Cell surface expression of fMet-Leu-Phe receptors on human neutrophils. Correlation to changes in the cytosolic free Ca2+ level and action of phorbol myristate acetate.

1987 • 68 citations

Metabolism of leukotriene B4 in the monkey. Identification of the principal nonvolatile metabolite in the urine

1984 • 62 citations

Studies on the mechanism of omega-hydroxylation of platelet 12-hydroxyeicosatetraenoic acid (12-HETE) by unstimulated neutrophils.

1987 • 60 citations

Metabolism of leukotrienes by L-gamma-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes.

1985 • 56 citations

Oxidation of leukotrienes at the omega end: demonstration of a receptor for the 20-hydroxy derivative of leukotriene B4 on human neutrophils and implications for the analysis of leukotriene receptors.

1984 • 51 citations

Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe

1986 • 46 citations

Effect of thiol-activated toxins (streptolysin O, alveolysin, and theta toxin) on the generation of leukotrienes and leukotriene-inducing and -metabolizing enzymes from human polymorphonuclear granulocytes

1985 • 42 citations

Diacylglycerol mass measurements in stimulated HL-60 phagocytes.

1987 • 32 citations

A novel metabolic pathway for leukotriene B4 in different cell types: primary reduction of a double bond

1987 • 32 citations

Binding and metabolism of leukotriene B₄ by neutrophils and their subcellular organelles

1986 • 31 citations

A comparison of the effects of soluble stimuli on free cytoplasmic and membrane bound calcium in human neutrophils

1984 • 26 citations

Novel pathway for the metabolism of 6-trans-leukotriene B4 by human polymorphonuclear leukocytes

1986 • 26 citations

Protein kinase C regulates leukotriene B₄ receptors in human neutrophils

1986 • 22 citations

NAD+-dependent conversion of 20-OH-LTB4 to 20-COOH-LTB4 by a cell-free system of human polymorphonuclear leukocytes

1985 • 21 citations

ω-Hydroxylation of N-acetylleukotriene E4 by rat liver microsomes

1987 • 20 citations

Characterization of Leukotriene B₄‐Omega‐Hydroxylase Activity within Human Polymorphonuclear Granulocytes

1987 • 18 citations

Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates

1987 • 14 citations

Metabolism of leukotriene D4 by porcine alveolar macrophages.

1984 • 9 citations

Association of leukotriene B4 with the cytoskeleton of rabbit neutrophils, effect of chemotactic factor and phorbol esters

1984 • 6 citations