CHEMISTRY, GENETICS, AND FUNCTION OF INVERTEBRATE RESPIRATORY PIGMENTS—CONFIGURATIONAL CHANGES AND ALLOSTERIC EFFECTS

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

The influence of some cations on an adenosine triphosphatase from peripheral nerves

1957 • 2,211 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin

1936 • 1,068 citations

Chemistry of the metal chelate compounds

1953 • 1,006 citations

The Enzymology of Control by Feedback Inhibition

1962 • 1,003 citations

Hematin compounds and bile pigments

1949 • 921 citations

Conformation Changes of Proteins

1954 • 859 citations

Further investigations on a Mg++ + Na+-activated adenosintriphosphatase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane

1960 • 799 citations

Reactions of the Cyanate Present in Aqueous Urea with Amino Acids and Proteins

1960 • 633 citations

Comparative animal physiology

1962 • 586 citations

Protein-Protein Interactions

1954 • 574 citations

Heme Proteins

1948 • 504 citations

THE RELATIONSHIP BETWEEN SULFHYDRYL GROUPS AND THE ACTIVATION OF MYOSIN ADENOSINETRIPHOSPHATASE

1956 • 392 citations

Modern trends in physiology and biochemistry

1952 • 352 citations

THE FUSION OF TWO PEPTIDE CHAINS IN HEMOGLOBIN LEPORE AND ITS INTERPRETATION AS A GENETIC DELETION

1962 • 331 citations

DEMONSTRATION OF TWO STABLE POTENTIAL STATES IN THE SQUID GIANT AXON UNDER TETRAETHYLAMMONIUM CHLORIDE

1957 • 323 citations

The Kinetic Basis of Molecular Biology

1954 • 308 citations

The molecular control of cellular activity

1963 • 274 citations

Protein Hydration and Behavior

1958 • 261 citations

The mechanism of enzyme action

1954 • 260 citations

Chromosomal Rearrangements and the Evolution of Haptoglobin Genes

1962 • 256 citations

The hemoglobins in genetics and evolution

1963 • 254 citations

SULFHYDRYL GROUPS AND THE STRUCTURE OF HEMOGLOBIN

1956 • 253 citations

The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine

1961 • 243 citations

The First Enzyme in Histidine Biosynthesis: The Nature of Feedback Inhibition by Histidine

1963 • 208 citations

The Binding of N-Ethylmaleimide by Human Hemoglobin and Its Effect upon the Oxygen Equilibrium

1961 • 198 citations

The Contribution of Hydrophobic Bonds to the Thermal Stability of Protein Conformations

1962 • 196 citations

Analytical description of the effects of modifiers and of enzyme multivalency upon the steady state catalyzed reaction rate

1953 • 192 citations

Enzyme flexibility and enzyme action

1959 • 192 citations

The determination of cuprous ion in copper proteins

1960 • 188 citations

The problem of the heme interactions in hemoglobin and the basis of the bohr effect

1951 • 185 citations

The Kinetics of Reactions Between Haemoglobin and Gases

1959 • 173 citations

Comparative Physiology: Blood Pigments

1960 • 158 citations

The Chemistry of the Bohr Effect

1961 • 151 citations

Animal Biochromes and Structural Colours

1953 • 150 citations

The Folding and Unfolding of Protein Molecules as a Basis of Osmotic Work

1952 • 150 citations

RESISTANCE OF METAL COMPLEXES OF CONALBUMIN AND TRANSFERRIN TO PROTEOLYSIS AND TO THERMAL DENATURATION

1958 • 141 citations

Demonstration of two stable states of the nerve membrane in potassium‐rich media

1959 • 141 citations

Studies on Carboxypeptidase Digests of Human Hemoglobin

1961 • 141 citations

Das Gleichgewicht zwischen Hämoglobin und Sauerstoff.

1938 • 139 citations

X-ray Analysis of Hemoglobin

1963 • 136 citations

Chemical and molecular basis of nerve activity

1960 • 136 citations

The Combining Power of Hemoglobin for Alkyl Isocyanides, and the Nature of the Heme-Heme Interactions in Hemoglobin

1951 • 136 citations

Hemerythrin: Molecular Weight and Dissociation into Subunits

1963 • 135 citations

Molecular biochemistry

1963 • 129 citations

Haemoglobin of Gastrophilus larvae. Purification and properties

1946 • 128 citations

Quantitative electron spin resonance studies on native and denatured ceruloplasmin and laccase

1962 • 127 citations

Studies on sodium-potassium-activated adenosinetriphosphatase. VI. Its role in cation transport in the lens of cat, calf and rabbit

1963 • 127 citations

Der Menschliche Rote Blutfarbstoff bei Fetus und Reifem Organismus

1954 • 127 citations

The respiratory function of hemocyanin in crustacea

1955 • 121 citations

The Influence of Oxygenation on the Reactivity of the —SH Groups of Hemoglobin^*

1962 • 120 citations

Control mechanisms in cellular processes

2011 • 119 citations

Oxygen Equilibrium of Hæmoglobin from Thunnus thynnus

1960 • 116 citations

Oxygen-Carrying Proteins: a Comparison of the Oxygenation Reaction in Hemocyanin and Hemerythrin with That in Hemoglobin

1955 • 116 citations

Electron microscope observations on some 60 s erythrocruorins and their split products

1963 • 115 citations

Structure and properties of hemocyanins. I. Electron micrographs of hemocyanin and apohemocyanin from Helix pomatia at different pH values.

1962 • 111 citations

The nature of the active site of hemerythrin

1957 • 108 citations

The Nature and Significance of the Bohr Effect in Mammalian Hemoglobins

1960 • 104 citations

THE HAEMOCYANINS

1934 • 103 citations

The Function of Haemoglobin in Chironomus Plumosus Under Natural Conditions

1950 • 101 citations

The effect of oxygen on the concentration of haem in invertebrates

1955 • 94 citations

A sibling species of sea cucumber discovered by starch gel electrophoresis

1963 • 92 citations

Hemoglobin and its Abnormalities

1962 • 89 citations

The interaction of bromthymol blue with hemoglobin and its effect on the oxygen equilibrium

1963 • 87 citations

Photochemische spaltung des kohlenoxydmyoglobins durch ultraviolette strahlung (wirksamkeit der durch die proteinkomponente des pigments absorbierten quanten)

1947 • 87 citations

IS THE RESTING POTENTIAL OF RANVIER NODES A POTASSIUM POTENTIAL?*

1959 • 86 citations

Structure of Molecules and Internal Rotation.

1955 • 82 citations

Starch gel electrophoresis of sera from some marine arthropods: Studies on the heterogeneity of hemocyanin and on a “ceruloplasmin-like protein”

1963 • 79 citations

Structure and properties of hemocyanins

1962 • 79 citations

Feedback inhibition of acetylglutamate synthetase by arginine in Escherichia coli

1963 • 77 citations

The Evolution of the Respiratory Function of the Blood

1933 • 76 citations

Regulation of the Enzymic Activity of Glutamic Dehydrogenase Mediated by Changes in Its Structure

1961 • 72 citations

SULFHYDRYL GROUPS AND THE INTERACTION BETWEEN THE HEMES IN HEMOGLOBIN

1952 • 72 citations

Histological specificity of respiratory pigments—II. Oxygen transfer systems involving hemerythrins in sipunculid worms of different ecologies

1960 • 70 citations

The carbon monoxide dissociation curve of human blood

1958 • 64 citations

Some immunochemical differences between associated and dissociated hemocyanin

1959 • 63 citations

The haemoglobins of Ascaris Lumbricoides

1949 • 63 citations

REVERSIBLE CHANGES OF PROTEIN CONFIGURATION IN STIMULATED NERVE STRUCTURES

1957 • 63 citations

Specific Reactions of Hydrogen Peroxide with the Active Site of Hemocyanin. The Formation of “Methemocyanin”¹

1959 • 62 citations

Studies on chlorocruorin. I. The oxygen equilibrium of Spirographis chlorocruorin

1962 • 61 citations

Observations On the Respiratory Physiology and On the Haemoglobin of the Polychaete Genus Nephthys, With Special Reference to N. Hombergii (Aud. Et M.-Edw.)

1955 • 58 citations

Étude de l'hémiglobine plasmatique de quelques annélides au microscope électronique

1960 • 55 citations

Biologic Activity of Soluble Antigen-Antibody Complexes

1959 • 55 citations

MECHANISM OF ENZYME ACTION

1960 • 54 citations

MOLECULAR GENETICS OF AVIAN PROTEINS, II. CONTROL GENES AND STRUCTURAL GENES FOR EMBRYONIC AND ADULT HEMOGLOBINS

1963 • 54 citations

Partition of Carbon Monoxide and Oxygen Between Air and Whole Blood of Rats, Dogs and Men as Affected by Plasma pH

1957 • 54 citations

Histological specificity of respiratory pigments—I. Comparisons of the coelom and muscle hemoglobins of the polychaete worm travisia pupa and the echiuroid worm arhynchite pugettensis

1960 • 53 citations

THE EQUILIBRIUM BETWEEN CYTOCHROME OXIDASE AND CARBON MONOXIDE

1957 • 51 citations

Denaturation of Hemoglobins by Alkali

1954 • 50 citations

The Hæmoglobin Particles

1961 • 50 citations

The chemistry and biology of hemoglobin in some marine clams—I. Distribution of the pigment and properties of the oxygen equilibrium

1963 • 50 citations

Hæmoglobin in the Crustacea

1957 • 49 citations

Oxygen Equilibrium of Brachiopod Lingula Hemerythrin

1960 • 48 citations

THE EFFECT OF CARBON DIOXIDE AND LACTIC ACID ON THE OXYGEN-COMBINING POWER OF WHOLE AND HEMOLYZED BLOOD OF THE MARINE FISH TAUTOGA ONITIS (LINN.)

1943 • 48 citations

The kinetics of blood pigments: hæmocyanin and hæmoglobin

1933 • 47 citations

Dissociation of Proteins into Sub-units by Succinylation: Hæmerythrin

1962 • 47 citations

The Stabilization of Horse Ferrihemoglobin to Acid Denaturation by Combination with Ligands^*

1963 • 43 citations

Studies on chlorocruorin

1962 • 42 citations

Studies on Cytochrome C

1959 • 42 citations

Preliminary observations on isolated Paramecium hemoglobin

1962 • 41 citations

Molecular and enzymatic studies of cardiac myosin

1962 • 41 citations

The oxygen-respiratory pigment equilibrium of the hemocyanin and myoglobin of the amphineuran mollusccryptochiton stelleri

1958 • 41 citations

CRYSTALLINE HAEMOCYANIN: SOME PHYSICAL AND CHEMICAL CONSTANTS

1940 • 40 citations

ON THE EVOLUTION OF HEMOGLOBIN. RESPIRATORY PROPERTIES OF THE HEMOGLOBIN OF THE CALIFORNIA HAGFISH, POLISTOTREMA STOUTI

1958 • 40 citations

OXYGEN-HEMOCYANIN RELATIONSHIPS IN THE LAND CRAB, CARDISOMA GUANHUMI

1962 • 39 citations

Alkaline denaturation and oxygen equilibrium of annelid hemoglobins

1959 • 39 citations

Negative-staining electron microscopy of proteins at pH values below their isoelectric points. Its application to hemocyanin

1960 • 39 citations

The multiple hemoglobins of some members of the Salmonidae family

1963 • 39 citations

Genetic Control of Hemerythrin Specificity in a Marine Worm

1963 • 39 citations

Substrate Control of Conformation Characteristics in Chymotrypsin

1963 • 39 citations

The Chemistry of Immunity in Health and Disease

1962 • 38 citations

Haemoglobin of the lamprey, Lampetra fluviatilis

1960 • 38 citations

Some kinetic and mechanistic aspects of hydrolytic enzyme action

1955 • 38 citations

Proteins and Nucleic Acids - Structure and Function

1962 • 38 citations

Molecular Adaptation in Hæmoglobins: Nature of The Bohr Effect

1959 • 38 citations

Chemical physiology of contraction in body and heart muscle

1954 • 36 citations

Recherches Sur Les Hémérythrines

1933 • 35 citations

The Combining Power of Normal Human Hemoglobin for Nitrosobenzene

1960 • 35 citations

A "Fetal-Maternal Shift" in the Ovoviviparous Spiny Dogfish Squalus suckleyi (Girard)

1958 • 35 citations

Respiration in the African Swampworm Alma Emini Mich

1957 • 34 citations

The occurrence of porphyrins in certain marine invertebrates

1954 • 34 citations

On chlorocruorin and haemoglobin

1949 • 34 citations

Arsenic Tribromide Immersion Liquids of High Index of Refraction

1955 • 34 citations

Heme-heme interactions in the oxygen equilibrium of some invertebrate myoglobins

1960 • 33 citations

On the binding of copper by hemocyanin

1959 • 33 citations

THE OXIDATION OF HEMOCYANIN

1933 • 33 citations

The properties of hemerythrin

1957 • 31 citations

An electron spin resonance study of copper valence in oxyhemocyanin

1960 • 30 citations

Decrease in thermal stability of frog liver carbamyl phosphate synthetase by substrates and cofactors

1959 • 30 citations

The binding of copper in haemocyanins

1958 • 30 citations

THE HEMOGLOBIN OF THE BIVALVED MOLLUSC, PHACOIDES PECTINATUS GMELIN

1962 • 30 citations

THE EQUILIBRIUM BETWEEN HEMOGLOBIN AND OXYGEN IN WHOLE AND HEMOLYZED BLOOD OF THE TAUTOG, WITH A THEORY OF THE HALDANE EFFECT

1941 • 30 citations

THE HYBRIDIZATION OF DONKEY AND MOUSE HEMOGLOBINS

1962 • 30 citations

Proton magnetic resonance studies on water in the presence of various macromolecular substances

1959 • 30 citations

The oxygen equilibrium of hemerythrin of Arenicola cristata

1952 • 30 citations

DENATURATION AND INACTIVATION OF ENZYME PROTEINS: XI. INACTIVATION AND DENATURATION OF GLUTAMIC ACID DEHYDROGENASE BY UREA, AND THE EFFECT OF ITS COENZYME ON THESE PROCESSES

1959 • 29 citations

THE COMBINATION OF CARBON MONOXIDE WITH HEMOCYANIN

1934 • 29 citations

Studies on the haemoglobin of Arenicola marina

1963 • 28 citations

A Sub-Molecular Mechanism of Gel Formation in Sickle Cell Hæmolysate

1962 • 28 citations

IMMUNOENZYMOLOGY‐REACTION PROCESSES, KINETICS AND THE ROLE OF CONFORMATIONAL ALTERATION*

1963 • 28 citations

Variations in heat stability of enzymes with substrates and cofactors

1959 • 27 citations

Gut haems in the invertebrates.

1955 • 26 citations

Hemoglobin oxygenation in relation to hydrostatic pressure

1948 • 25 citations

Effect of Insulinase-Inhibitor on Hypoglycemic Action of Insulin

1955 • 25 citations

Oxygen equilibrium of Cucumaria miniata hemoglobin and the absence of the Bohr effect

1959 • 24 citations

Dielectric Properties of Hemoglobin. II. Anomalous Dispersion during Oxygenation

1958 • 24 citations

The Respiratory Characteristics of Chiton Hemocyanins

1962 • 24 citations

Oxygen Equilibrium of Phascolosoma agassizii Hemerythrin

1958 • 24 citations

Biochemical Mechanisms

1963 • 23 citations

The binding of copper by hemocyanin

1954 • 23 citations

The X-ray molecular weight of hemerythrin from Phascolosoma gouldi and some notes on the oxygenation reaction

1957 • 23 citations

The effect of hemolysis upon the combination of oxygen with the blood of some marine fishes

1939 • 23 citations

Presence of Myoglobin in "Cartilage" of the Marine Snail Busycon

1959 • 22 citations

THE COMBINING POWER OF MYOGLOBIN FOR ALKYL ISOCYANIDES AND THE STRUCTURE OF THE MYOGLOBIN MOLECULE

1956 • 22 citations

On the function of chlorocruorin

1940 • 22 citations

Étude thermodynamique de l'association heme-globine II. Méthémoglobine

1962 • 22 citations

Effect of Insulin on Sulphydryl Groups in Muscle

1959 • 21 citations

Dielectric Properties of Hemoglobin. I. Studies at 1 Megacycle

1956 • 20 citations

The oxygen affinity of chlorocruorin

1932 • 19 citations

Nuclear magnetic relaxation of water protons by ferrihemoglobin and ferrimyoglobin

1959 • 19 citations

The Effect of Carbon Dioxide and Certain Respiratory Inhibitors on the Respiration of Larvae of the Horse Bot Fly (Gastrophilus Intestinalis De Geer)

1951 • 19 citations

Decrease of the Copper Bands of Helix pomatia Hæmocyanin

1960 • 19 citations

The fluorescence of α-chymotrysin in the presence of substrates and inhibitors

1962 • 19 citations

Molecular changes in myosin caused by methylmercuric hydrome

1961 • 19 citations

Major Problems in Muscle Physiology

1961 • 18 citations

THE MECHANISM OF ANTIBODY‐ANTIGEN INTEMCTION AND THE THEORY OF SUBCOMPLEMENTARITY BETWEEN THE REACTIVE SITES OF ANTIBODY AND ANTIGEN*

1963 • 18 citations

Some observations on the reactions of two annelid haemoglobins with oxygen and with carbon monoxide

1955 • 17 citations

The Problem of ‘Methæmocyanin’

1961 • 17 citations

The Mechanism of Clot Retraction

1950 • 17 citations

THE EFFECT OF OXIDIZING AGENTS ON HAEMOCYANIN

1941 • 17 citations

A Study of the Oxygen Equilibrium of Horse Hemoglobin

1955 • 17 citations

Biochemical Evolution

1949 • 16 citations

Magnetic Susceptibilities of Reduced and Oxygenated Hemerythrins

1953 • 16 citations

Influence of Hydrostatic Pressure on the Denaturation of Staphylococcus Antitoxin at 65°C

1946 • 15 citations

Molecular association behavior of apomyoglobin I from the seal (Phoca vitulina)

1962 • 15 citations

PROPERTIES OF THE ACTIVE SITE OF ENZYMES*

1963 • 14 citations

Interaction between Oxygen and Oxygen-Carrying Proteins

1955 • 13 citations

Oxygen-linked acidity in dye-conjugates of hemoglobin and hemocyanin

1962 • 13 citations

Histological and histochemical observations upon an aberrant annelid, Poeobius meseres Heath

1947 • 13 citations

Dielectric properties of hemoglobin. V. Temperature dependence and urea denaturation

1958 • 12 citations

On the Nature of the Interaction between Binding Sites for Heavy Metals (Mercapto-Mercapto Interactions) in Normal Human Hemoglobin

1959 • 12 citations

THE EFFECT OF FORMALDEHYDE ON THE OXYGEN EQUILIBRIUM OF HEMOGLOBIN

1954 • 12 citations

Molecular Weight of Chicken Liver Glutamic Acid Dehydrogenase in Relation to the Activating Effect of Methylmercuric Bromide

1963 • 12 citations

The Investigation of Haemoglobin and Myoglobin Derivatives by Electron Resonance

1957 • 11 citations

The kinetics of haemoglobin reactions

1943 • 11 citations

The effect of urea on the oxygen equilibrium of mammalian hemoglobins

1959 • 11 citations

CHANGES IN PROTEIN TOPOGRAPHY UPON OXYGENATION

1957 • 11 citations

The reaction of haemoglobin and some of its derivatives with p-iodophenylhydroxylamine and p-iodonitrosobenzene

1954 • 10 citations

The heat of reaction of the oxygenation of hemocyanin

1933 • 9 citations

THE HEME-GLOBIN LINKAGE OF HEMOGLOBIN

1941 • 9 citations

THE DETERMINATION OF ELECTRONIC PROPERTIES BY PROTEIN STRUCTURE IN HEMEPROTEIN

1961 • 9 citations

Interrelation Between the Function of Heme-proteins and the Structural Modifications of their Protein Parts

1959 • 9 citations

REVERSIBLE CHANGES IN THE NEM-REACTIVE —SH GROUPS OF HEMOGLOBIN ON OXYGENATION-DEOXYGENATION

1962 • 9 citations

Physicochemical aspects of hydrogen bonds and their application to biology.

1962 • 8 citations

Titratable Sulfhydryl Groups of Horse, Sheep, Dog, and Cow Hemoglobins at 0° and 38°

1958 • 8 citations

Oxygen Dissociation Curves in Fish Blood¹

1957 • 7 citations

Bohr Effect in the Hæmoglobins of Marine Mammals

1961 • 7 citations

PROGRESS OF X-RAY ANALYSIS OF ORGANIC AND FIBRE STRUCTURES

1946 • 7 citations

Oxygen Affinities of Respiratory Blood Pigments in Serpula

1951 • 5 citations

Dielectric Properties of Hemoglobin. VI. Measurements with Solid Materials

1958 • 5 citations

Dielectric Properties of Hemoglobin. III. Carbon Monoxide Addition to Horse Hemoglobin

1958 • 5 citations

Diffusion across rat diaphragm I. Movement of sodium and potassium; effect of eachalion and correlation with protein structure

1963 • 5 citations

THE EFFECT OF ACIDITY ON THE CARBON MONOXIDE-COMBINING POWER OF HEMOGLOBIN IN THE BLOOD OF MARINE FISHES

1934 • 5 citations

Effects of Ionizing Radiation and Peroxides on Hæmocyanin

1962 • 5 citations

Die Koagulationstemperaturen einiger Hämoglobinverbindungen

1957 • 4 citations

Diffusion across rat diaphragm II. Movement of sugars; effect of insulin and other agents

1963 • 4 citations

Excitation processes in a receptor membrane

1962 • 3 citations

THE HEME-GLOBIN LINKAGE OF HEMOGLOBIN III. ANALYSIS OF THE CARBON MONOXIDE PRODUCT. THE PANCREATIC DIGESTIONS OF SEVERAL FORMS OF HEMOGLOBIN

1941 • 3 citations

Magnetic Susceptibility of Erythrocruorin from the Blood of an Ark-Shell

1956 • 3 citations

The Oxygen Equilibrium of Denatured Hemoglobin and the Mechanism of Denaturation

1956 • 2 citations

Differenzen der optischen Drehung bei H�moglobinverbindungen verschiedener Spezies

1960 • 2 citations

Dielectric properties of hemoglobin interaction between hydrogen peroxide and methemoglobin

1961 • 2 citations

Analogies and Differences between Human and Horse Hæmoglobin

1962 • 2 citations

A note on the dielectric dispersion of deuterium oxide solutions of horse hemoglobin

1959 • 1 citations

Response : Interaction between Oxygen and Oxygen-Carrying Proteins

1955 • 1 citations