Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA

Experiments in molecular genetics

1972 • 28,260 citations

Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

1981 • 3,596 citations

Messenger RNA degradation in eukaryotes

1993 • 858 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

1986 • 684 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

Ribosome pausing and stacking during translation of a eukaryotic mRNA.

1988 • 468 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

Solution structure of an unusually stable RNA hairpin, 5GGAC(UUCG)GUCC

1990 • 420 citations

Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

1990 • 409 citations

mRNA poly(A) tail, a 3' enhancer of translational initiation.

1990 • 353 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

1988 • 345 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

1991 • 297 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

The a-factor pheromone of Saccharomyces cerevisiae is essential for mating.

1988 • 248 citations

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.

1991 • 243 citations

Mutations affecting stability and deadenylation of the yeast MFA2 transcript.

1992 • 228 citations

A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons.

1993 • 192 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation.

1987 • 177 citations

Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component

1989 • 172 citations

mRNA Structures Influencing Translation in the Yeast Saccharomyces cerevisiae

1988 • 167 citations

RNA pseudoknot domain of tobacco mosaic virus can functionally substitute for a poly(A) tail in plant and animal cells.

1990 • 152 citations

Mutational Analysis of the HIS4 Translational Initiator Region in Saccharomyces cerevisiae

1988 • 142 citations

Inhibition of translational initiation in the yeast Saccharomyces cerevisiae as a function of the stability and position of hairpin structures in the mRNA leader.

1993 • 136 citations

Evidence for an essential non-Watson–Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

1993 • 133 citations

Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region Is Mediated by a Cotranslational Mechanism

1993 • 131 citations

Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.

1991 • 127 citations

Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export.

1994 • 110 citations

The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth.

1989 • 105 citations

Poly(A) Tail Shortening Is the Translation-Dependent Step in c-myc mRNA Degradation

1990 • 100 citations

A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.

1992 • 87 citations

The Destabilizing Elements in the Coding Region of c-fos mRNA Are Recognized as RNA

1993 • 71 citations

Control of messenger RNA stability

1994 • 61 citations

Translation of c-myc mRNA is required for its post-transcriptional regulation during myogenesis.

1990 • 54 citations

Translational regulation of human beta interferon mRNA: association of the 3' AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro.

1993 • 47 citations