Gene-environment Interaction: Variability Gene Concept

Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.

1983 • 4,204 citations

An Adoption Study of Human Obesity

1986 • 1,308 citations

Variability of Body Weight and Health Outcomes in the Framingham Population

1991 • 638 citations

World Review of Nutrition and Dietetics.

1969 • 377 citations

Effects of dietary cholesterol on the regulation of total body cholesterol in man

1971 • 321 citations

EXISTENCE OF CONSISTENT HYPO- AND HYPERRESPONDERS TO DIETARY CHOLESTEROL IN MAN1

1986 • 265 citations

Individual Variation in the Effects of Dietary Cholesterol on Plasma Lipoproteins and Cellular Cholesterol Homeostasis in Man

1981 • 241 citations

DNA polymorphism at the locus for human cholesteryl ester transfer protein (CETP) is associated with high density lipoprotein cholesterol and apolipoprotein levels

1989 • 182 citations

Changes in cholesterol synthesis and excretion when cholesterol intake is increased

1976 • 164 citations

CHARACTERISTICS OF HUMAN HYPO- AND HYPERRESPONDERS TO DIETARY CHOLESTEROL

1987 • 160 citations

VARIATION OF APOLIPOPROTEIN-B GENE IS ASSOCIATED WITH OBESITY, HIGH BLOOD CHOLESTEROL LEVELS, AND INCREASED RISK OF CORONARY HEART DISEASE

1988 • 115 citations

Genetics of coronary heart disease.

1983 • 104 citations

Twin Studies of Coronary Heart Disease and Its Risk Factors

1987 • 98 citations

Reproducibility of the variations between humans in the response of serum cholesterol to cessation of egg consumption

1985 • 95 citations

Twin Studies of Coronary Heart Disease and Its Risk Factors

1984 • 93 citations

Inbred Mice and their Hybrids as an Animal Model for Atherosclerosis Research

1976 • 82 citations

Relationship between sensitivity to dietary fat and dietary cholesterol.

1990 • 76 citations

Genetic control of plasma cholesterol. Studies on squirrel monkeys.

1971 • 73 citations

Cholesterol metabolism in groups of rhesus monkeys with high or low response of serum cholesterol to an atherogenic diet

1976 • 68 citations

Atherosclerosis Drug Discovery

1976 • 68 citations

Genetic studies on induced and spontaneous hypercholesterolemia in rats

1973 • 62 citations

Genetic Variation and Nutrition

1999 • 58 citations

Rabbits as a Model for the Study of Hyperlipoproteinemia and Atherosclerosis

1976 • 49 citations

From Phenotype to Gene in Common Disorders

1990 • 49 citations

“Variability gene” effect of cholesteryl ester transfer protein (CETP) genes

1989 • 46 citations

Genetics of Coronary Heart Disease and its Risk Factors

2007 • 45 citations

Variability gene effect on cholesterol at the Kidd blood group locus

1988 • 45 citations

Apparent influence of marker genotypes on variation in serum cholesterol in monozygotic twins

1981 • 42 citations

VARIATIONS IN SERUM LIPID CONCENTRATION AND CLINICAL CORONARY DISEASE

1960 • 41 citations

Cholesterol Response in Inbred Strains of Rats, Rattus norvegicus

1981 • 32 citations

Twin research in coronary heart disease.

1981 • 30 citations

Breed differences in the responses of rabbits to atherogenic diets

1972 • 29 citations

The genetics of coronary heart disease

1992 • 28 citations

Molecular Approaches to Human Polygenic Disease

1988 • 22 citations

Within‐individual variation in serum cholesterol levels: association with DNA polymorphisms at the apolipoprotein B and AI‐CIII‐AIV loci in patients with peripheral arterial disease

1991 • 21 citations

Molecular approaches to human polygenic disease.

1987 • 18 citations

Predictive genetic testing to control coronary heart disease and hyperlipidemia.

1989 • 16 citations

Role of genetic factors in atherosclerotic disease

1989 • 15 citations

Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.

1989 • 13 citations

Introductory Remarks: Risk Factor Levels and Variability

1992 • 11 citations

A new tool in birth defects research: the MZ half-sib model and its extension to grandchildren of identical twins.

1978 • 8 citations

Molecular genetics and nutrition.

1990 • 4 citations