Glycine: Inhibition from the Sacrum to the Medulla

THE PHYSIOLOGY OF SYNAPSES

1964 • 1,932 citations

The Physiology of Synapses

1964 • 1,239 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Characteristics of Excitatory and Inhibitory Synapses in the Central Nervous System of the Cat

1965 • 914 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Iontophoretic studies of neurones in the mammalian cerebral cortex

1963 • 659 citations

A pharmacological study of the depression of spinal neurones by glycine and related amino acids

1968 • 505 citations

The chemical excitation of spinal neurones by certain acidic amino acids

1960 • 484 citations

The hyperpolarization of spinal motoneurones by glycine and related amino acids

1968 • 481 citations

High affinity uptake systems for glycine, glutamic and aspartic acids in synaptosomes of rat central nervous tissues

1972 • 476 citations

Acidic amino acids with strong excitatory actions on mammalian neurones

1963 • 415 citations

Inhibitory of glycine on spinal neurons in the cat.

1968 • 411 citations

Fluorometric determination of aspartate, glutamate, and γ-aminobutyrate in nerve tissue using enzymic method

1966 • 388 citations

Strychnine Binding Associated with Glycine Receptors of the Central Nervous System

1973 • 388 citations

DISTRIBUTION OF SOME SYNAPTIC TRANSMITTER SUSPECTS IN CAT SPINAL CORD: GLUTAMIC ACID, ASPARTIC ACID, γ‐AMINOBUTYRIC ACID, GLYCINE, AND GLUTAMINE *

1967 • 373 citations

The glycine cleavage system: Composition, reaction mechanism, and physiological significance

1973 • 360 citations

Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions

1974 • 356 citations

The pharmacology of amino acids related to gamma-aminobutyric acid.

1965 • 333 citations

Metabolic Compartmentation and Neurotransmission

1975 • 301 citations

Immunocytochemical localization of glutamate decarboxylase in rat spinal cord

1975 • 288 citations

The distribution of glycine in cat spinal cord and roots

1965 • 282 citations

GLYCINE UPTAKE IN RAT CENTRAL NERVOUS SYSTEM SLICES AND HOMOGENATES: EVIDENCE FOR DIFFERENT UPTAKE SYSTEMS IN SPINAL CORD AND CEREBRAL CORTEX

1971 • 256 citations

HIGH AFFINITY UPTAKE OF TRANSMITTERS: STUDIES ON THE UPTAKE OF <scp>l</scp>‐ASPARTATE, GABA, <scp>l</scp>‐GLUTAMATE AND GLYCINE IN CAT SPINAL CORD

1973 • 236 citations

Micro‐iontophoretic studies on neurones in the cuneate nucleus

1967 • 227 citations

Tetanus Toxin: Direct Evidence for Retrograde Intraaxonal Transport

1975 • 224 citations

The depression of spinal neurones by γ‐amino‐n‐butyric acid and β‐alanine

1959 • 216 citations

CHANGES IN AMINO ACID CONCENTRATIONS ASSOCIATED WITH LOSS OF SPINAL INTERNEURONS *

1967 • 211 citations

Effect of thyroid hormone on the biochemical maturation of rat brain: Postnatal cell formation

1971 • 207 citations

MECHANISMS OF SYNAPTIC TRANSMISSION IN THE CUNEATE NUCLEUS

1964 • 195 citations

Tetanus toxin and spinal inhibition

1968 • 191 citations

Is Glycine a Neurotransmitter ?: Inhibition of Motoneurones by Iontophoresis of Glycine

1967 • 189 citations

Pharmacology of cortical inhibition

1966 • 182 citations

Strychnine Binding in Rat Spinal Cord Membranes Associated with the Synaptic Glycine Receptor: Cooperativity of Glycine Interactions

1974 • 165 citations

GABA-picrotoxin interaction in the mammalian central nervous system

1969 • 164 citations

Potassium-induced release of amino acids from cerebral cortex and spinal cord slices of the rat

1974 • 156 citations

THE METABOLISM IN VIVO OF GLYCINE AND SERINE IN EIGHT AREAS OF THE RAT CENTRAL NERVOUS SYSTEM¹

1970 • 154 citations

A comparison of the concentration of glycine, a transmitter suspect, in different areas of the brain and spinal cord in seven different vertebrates

1969 • 151 citations

THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS

1964 • 143 citations

AMINO ACIDS IN SYNAPTIC VESICLES FROM MAMMALIAN CEREBRAL CORTEX: A REAPPRAISAL

1973 • 142 citations

DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

1973 • 141 citations

ACTIVE TRANSPORT OF AMINO ACID INTO CEREBRAL CORTEX SLICES*

1963 • 139 citations

Tetanus toxin and the synaptic release of GABA

1973 • 136 citations

The Glycine Synaptic Receptor: Evidence That Strychnine Binding Is Associated with the Ionic Conductance Mechanism

1974 • 136 citations

Interaction of Benzodiazepines with Central Nervous Glycine Receptors: Possible Mechanism of Action

1974 • 136 citations

Metabolic response of synaptosomes to electrical stimulation: Release of amino acids

1970 • 131 citations

The pharmacology of central and peripheral inhibition.

1963 • 128 citations

Light and electron microscopic autoradiography on spinal cord slices after incubation with labeled glycine

1971 • 127 citations

THE DISTRIBUTION OF GLYCINE, GABA, GLUTAMATE AND ASPARTATE IN RABBIT SPINAL CORD, CEREBELLUM AND HIPPOCAMPUS

1977 • 120 citations

THE FREE AMINO ACIDS OF HUMAN SPINAL FLUID DETERMINED BY ION EXCHANGE CHROMATOGRAPHY

1966 • 119 citations

The release of amino acids with proposed neurotransmitter function from the cuneate and gracile nuclei of the rat in vivo

1974 • 115 citations

PATTERNS OF AMINO ACID RELEASE FROM NERVE-ENDINGS ISOLATED FROM SPINAL CORD AND MEDULLA

1973 • 114 citations

The uptake of [¹⁴C]glycine by slices of mammalian spinal cord

1971 • 112 citations

Iontophoretic studies in deiter's nucleus of the inhibitory actions of GABA and related amino acids and the interactions of strychnine and picrotoxin

1971 • 110 citations

Autoradiographic uptake patterns of [3H]GABA and [3H]-glycine in central nervous tissues with special reference to the cat spinal cord

1973 • 110 citations

The in vivo inactivation of GABA and other inhibitory amino acids in the cat nervous system

1976 • 94 citations

The effects of strychnine on the inhibition of interneurons by glycine and γ-aminobutyric acid

1969 • 94 citations

THE INTRASPINAL DISTRIBUTION OF SOME DEPRESSANT AMINO ACIDS

1968 • 92 citations

Glycine metabolism in rat liver mitochondria

1971 • 91 citations

Uptake of 14C Glycine by Spinal Cord

1969 • 90 citations

Depression of cerebellar Purkinje cells by microiontophoretic application of GABA and related amino acids

1970 • 88 citations

NEUROCHEMICAL CORRELATES OF BEHAVIOR

1976 • 88 citations

A COMPARATIVE STUDY OF BRAIN AND LIVER MITOCHONDRIA FROM NEW‐BORN AND ADULT RATS

1969 • 87 citations

Tetanus toxin: evidence for binding at presynaptic nerve endings

1977 • 86 citations

A pharmacological study of Renshaw cell inhibition.

1976 • 85 citations

Is Glycine a Neurotransmitter ?: Association of Glycine with Spinal Interneurones

1967 • 84 citations

THE RELEASE OF AMINO ACIDS FROM THE HEMISECTED SPINAL CORD DURING STIMULATION

1972 • 80 citations

Strychnine and Cortical Inhibition

1967 • 78 citations

The action of glycine on cortical neurones

1969 • 77 citations

Actions of amino acids and convulsants on bulbar reticular neurones

1970 • 76 citations

DISTRIBUTION OF FOUR POTENTIAL TRANSMITTER AMINO ACIDS IN MONKEY RETINA

1977 • 72 citations

Major Pathways of Serine and Glycine Catabolism in Various Organs of the Rat and Cock*

1973 • 71 citations

ANTAGONISM OF γ‐AMINOBUTYRIC ACID AND GLYCINE BY CONVULSANTS IN THE CUNEATE NUCLEUS OF CAT

1976 • 71 citations

Studies on experimental thiamine deficiency. Trends of keto acid formation and detection of glyoxylic acid

1962 • 70 citations

Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior

1975 • 70 citations

Neurochemical Correlates of Behavior

1970 • 66 citations

Glycine metabolism by rat liver mitochondria

1969 • 66 citations

Presynaptic Inhibitory Actions: Presynaptic Inhibition in the Cuneate Nucleus

1962 • 65 citations

THE BRAIN BARRIER SYSTEM—V STEREOSPECIFICITY OF AMINO ACID UPTAKE, EXCHANGE AND EFFLUX

1963 • 64 citations

DECREASED METABOLISM IN VIVO OF GLUCOSE INTO AMINO ACIDS OF THE BRAIN OF THIAMINE‐DEFICIENT RATS AFTER TREATMENT WITH PYRITHIAMINE

1975 • 63 citations

Patterns of firing in cuneate neurones and some effects of flaxedil

1968 • 63 citations

BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS

1976 • 63 citations

Antagonism between bicuculline, strychnine, and picrotoxin and depressant amino-acids in the rat nervous system

1972 • 62 citations

Strychnine-Resistant Central Inhibition: Strychnine and Cortical Inhibition

1963 • 60 citations

DISTRIBUTION OF SERINE HYDROXYMETHYLTRANSFERASE AND GLYCINE TRANSAMINASE IN SEVERAL AREAS OF THE CENTRAL NERVOUS SYSTEM OF THE RAT

1974 • 59 citations

Neurochemical Evidence for Glycine as a Transmitter and a Model for Its Intrasynaptosomal Compartmentation

1975 • 58 citations

Strychnine-sensitive inhibition in the medullary reticular formation: Evidence for glycine as an inhibitory transmitter

1972 • 57 citations

Analysis of glycine actions on spinal interneurones by intracellular recording

1968 • 56 citations

Method for multiple analyses of concentration and specific radioactivity of individual amino acids in nervous tissue extracts

1970 • 55 citations

Release of exogenous glycine in the pigeon optic tectum during stimulation of a midbrain nucleus

1976 • 52 citations

THE OXIDATION OF GLYCINE BY <scp>d</scp>‐AMINO ACID OXIDASE IN EXTRACTS OF MAMMALIAN CENTRAL NERVOUS TISSUE

1969 • 51 citations

Glycine-specific synapses in rat spinal cord. Identification by electron microscope autoradiography.

1976 • 49 citations

Rigidity in Man Due to Spinal Interneuron Loss

1967 • 49 citations

An autoradiographic study of uptake of exogenous glycine by vertebrate spinal cord splicesin vitro

1972 • 45 citations

A Block in Glycine Cleavage Reaction as a Common Mechanism in Ketotic and Nonketotic Hyperglycinemia

1974 • 45 citations

Pharmacological studies of recurrent cortical inhibition and facilitation

1965 • 44 citations

The effects of glycine, GABA and strychnine on sacral parasympathetic preganglionic neurones

1970 • 44 citations

Histoautoradiographic localisation of 125I-labeled tetanus toxin in rat spinal cord

1973 • 43 citations

Effects of glycine and GABA, and blocking actions of strychnine and picrotoxin in the hypoglossus nucleus

1972 • 43 citations

The effect of some depressing amino acids on bulbar respiratory and non-respiratory neurons

1975 • 42 citations

TETANUS TOXIN AND AMINO ACID LEVELS IN CAT SPINAL CORD

1969 • 39 citations

A Familial Spinal Cord Disorder

1972 • 39 citations

Tetanus toxin induced actions on spinal Renshaw cells and Ia-inhibitory interneurones during development of local tetanus in the cat

1977 • 38 citations

Glycine Metabolism by Rat Liver Mitochondria: III. The Glycine Cleavage and the Exchange of Carboxyl Carbon of Glycine with Bicarbonate&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;*&lt;/sup&gt;&lt;/xref&gt;

1969 • 38 citations

SERINE TRANSHYDROXYMETHYLASE IN DEVELOPING MOUSE BRAIN¹

1968 • 38 citations

Glycine: 2-oxoglutarate transaminase in rat cerebral cortex

1969 • 37 citations

REGIONAL DISTRIBUTION AND PROPERTIES OF THE GLYCINE CLEAVAGE SYSTEM WITHIN THE CENTRAL NERVOUS SYSTEM OF THE RAT: EVIDENCE FOR AN ENDOGENOUS INHIBITOR DURING IN VITRO ASSAY

1976 • 36 citations

Post-synaptic Inhibition in the Cuneate blocked by GABA Antagonist

1971 • 35 citations

Precursors of glycine in the nervous system: Comparison of specific activities in glycine and other amino acids after administration of [U-14C]glucose, [3,4-14C]glucose, [1-14C]glucose, [U-14C]serine or [1,5-14C]citrate to the rat

1973 • 35 citations

On the pharmacology of the glycine receptors on the cuneo‐thalamic relay cells in the cat

1973 • 33 citations

Development of the synaptic glycine receptor in chick embryo spinal cord

1975 • 33 citations

Neurosciences Research

1969 • 33 citations

Methylenetetrahydrofolate reductase in the rat central nervous system: Intracellular and regional distribution

1975 • 31 citations

Familial hyperglycinuria

1973 • 31 citations

Pharmacology of the brachium conjunctivum: Red nucleus synaptic system in the baboon

1977 • 31 citations

Evidence for the net accumulation of glycine into a synaptosomal fraction isolated from the telencephalon and spinal cord of the rat

1973 • 30 citations

Ontogeny of Behavioral Sensitivity to Strychnine in the Chick Embryo: Evidence for the Early Onset of CNS Inhibition

1975 • 29 citations

THE OCCURRENCE OF A GLYCINE CLEAVAGE SYSTEM IN MAMMALIAN BRAIN¹

1973 • 29 citations

A Patient with Nonketotic Hyperglycinemia: Biochemical Findings and Therapeutic Approaches

1974 • 28 citations

Valine-sensitive nonketotic hyperglycinemia

1974 • 27 citations

EFFECT OF TETANUS TOXIN ON THE CONTENT OF GLYCINE, GAMMA-AMINOBUTYRIC ACID, GLUTAMATE, GLUTAMINE AND ASPARTATE IN THE RAT SPINAL CORD²

1971 • 27 citations

Glycine-producing transaminase activity in extracts of spinal cord

1969 • 25 citations

Glycine‐mediated inhibitory transmission of group 1A‐excited inhibitory interneurones by Renshaw cells.

1976 • 23 citations

Neurochemical correlates of spasticity

1976 • 23 citations

Research Approaches to Problems in Mental Illness: Brain Neurohumor–Enzyme Systems and Behavior

1965 • 23 citations

Bicuculline and the depression of medullary reticular neurones by GABA and glycine

1971 • 22 citations

Effects of glycine on spinal neurones grown in tissue culture

1971 • 20 citations

Effect of tetanus toxin on presynaptic inhibition in the spinal cord.

1966 • 20 citations

Distribution of glycine in human spinal cord and selected regions of brain

1973 • 20 citations

Light and the spontaneous efflux of radioactive glycine from the frog retina

1974 • 19 citations

Acute Neonatal Nonketotic Hyperglycinemia: Normal Propionate and Methylmalonate Metabolism

1975 • 19 citations

The emergence of inhibition in the chick embryo spinal cord

1974 • 18 citations

Neuronal pathology in experimental local tetanus

1973 • 18 citations

Uptake of [³H]glycine and [¹⁴C]glutamate by cultures of chick spinal cord

1973 • 18 citations

Plasma-CSF Glycine Ratio in Normal and Nonketotic Hyperglycinemic Subjects

1975 • 18 citations

The specificity of molecular processes involved in neural transmission

1965 • 17 citations

Interconversion of glycine and serine in a synaptosome fraction isolated from the spinal cord, medulla oblongata, telencephalon, and cerebellum of the rat

1973 • 16 citations

Advances in tetanus research

1974 • 14 citations

Rigidity and primary motoneuron damage in tetanus

1974 • 13 citations

GLYCINE DECARBOXYLATION IN THE CENTRAL NERVOUS SYSTEM

1973 • 12 citations

Metabolism of Glyoxylate in Nonketotic Hyperglycinemia

1969 • 12 citations

Levels of ɤ-aminobutyric acid in the dorsal grey lumbar spinal cord during the development of experimental spinal spasticity

1976 • 12 citations

Amino acid antagonists and the depression of cuneate neurones by -aminobutyric acid (GABA) and glycine.

1973 • 11 citations

Interpretation of elevated blood glycine levels in children

1975 • 10 citations

Distribution of amino acids between plasma and spinal fluid.

1966 • 10 citations

Brain glycine and aggressive behavior

1975 • 9 citations

Glycine metabolism by rat liver mitochondria-1,3-

1969 • 9 citations

Effect of glycine upon stretch reflex tension

1972 • 8 citations

Proceedings: Distribution and localization of tritiated amino acids by autoradiography in the cat spinal cord in vivo.

1976 • 6 citations