The pH dependency of bovine spleen cathepsin B-catalyzed transfer of N alpha-benzyloxycarbonyl-L-lysine from p-nitrophenol to water and dipeptide nucleophiles. Comparisons with papain.

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Biophysical Chemistry

1958 • 631 citations

The Structure of Papain

1971 • 242 citations

Kinetics of Papain-Catalyzed Hydrolysis of α-N-Benzoyl-L-arginine Ethyl Ester and α-N-Benzoyl-L-argininamide¹

1965 • 204 citations

Effect of cysteine-25 on the ionization of histidine-159 in papain as determined by proton nuclear magnetic resonance spectroscopy. Evidence for a histidine-159-cysteine-25 ion pair and its possible role in catalysis

1981 • 154 citations

Proteinase‐Catalyzed Synthesis of Peptide Bonds

1982 • 150 citations

The Kinetics of α-Chymotrypsin Reactions in the Presence of Added Nucleophiles

1964 • 138 citations

Potentiometric determination of ionizations at the active site of papain

1976 • 127 citations

Protein Degradation in Health and Disease

1981 • 124 citations

On the Mode of Activation of the Catalytically Essential Sulfhydryl Group of Papain

1973 • 112 citations

14 Papain and Other Plant Sulfhydryl Proteolytic Enzymes

1971 • 106 citations

The Reactivity of Nucleophilic Reagents with Furoyl-chymotrypsin

1965 • 92 citations

The Kinetics and Mechanism of Papain-Catalyzed Hydrolyses¹

1966 • 92 citations

Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-<scp>l</scp>-arginyl-<scp>l</scp>-arginine 2-naphthylamide to a study of the inhibition by leupeptin

1980 • 91 citations

Kinetics of papain-catalyzed hydrolysis of α-N-benzoyl-L-arginine-p-nitroanilide

1973 • 89 citations

Protein degradation in health and disease.

1980 • 87 citations

Determination of a low pK for histidine-159 in the S-methylthio derivative of papain by proton nuclear magnetic resonance spectroscopy

1981 • 56 citations

pH dependencies of individual rate constants in papain-catalyzed reactions

1969 • 55 citations

Specific spectrophotometric assays for cathepsin B1

1975 • 54 citations

Co‐operative Ionisation of Aspartic‐Acid‐158 and Histidine‐159 in Papain

1976 • 41 citations

Benzoylamidoacetonitrile as an inhibitor of papain

1973 • 35 citations

Mechanism of association of N-acetyl-L-phenylalanylglycinal to papain

1981 • 33 citations

Dependence of the catalytic activity of papain on the ionization of two acidic groups.

1978 • 29 citations

The reaction of trans-cinnamoyl-papain with a series of polyglycinamides of varying chain length

1967 • 27 citations

A Spectroscopic Investigation of S‐Trifluoroethylthiopapain

1976 • 20 citations

Solvent isotope effects on tautomerization equilibria of papain and model thiolamines

1980 • 19 citations

Analogy between active sites of cathepsin B₁ and papain

1970 • 12 citations