CD4⁺T cell-mediated control of a γ-herpesvirus in B cell-deficient mice is mediated by IFN-γ

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

HUMAN CYTOTOXIC T LYMPHOCYTE RESPONSES TO EPSTEIN-BARR VIRUS INFECTION

1997 • 769 citations

Complete sequence and genomic analysis of murine gammaherpesvirus 68

1997 • 736 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways

1998 • 375 citations

Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection

1998 • 356 citations

Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo

1992 • 351 citations

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells.

1990 • 340 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68

1996 • 270 citations

Immunopathogenesis of HIV Infection

2002 • 252 citations

Epstein-Barr virus strategy in normal and neoplastic B cells

1994 • 251 citations

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands

1992 • 243 citations

Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells.

1992 • 237 citations

Murine γ-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-γ responsiveness: A new model for virus-induced vascular disease

1997 • 225 citations

Interferon γ Regulates Acute and Latent Murine Cytomegalovirus Infection and Chronic Disease of the Great Vessels

1998 • 210 citations

Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells

1993 • 192 citations

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice.

1996 • 185 citations

Cloning and molecular characterization of the murine herpesvirus 68 genome

1990 • 170 citations

Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig.

1996 • 157 citations

Control of Acute Cutaneous Herpes Simplex Virus Infection: T Cell-Mediated Viral Clearance Is Dependent upon Interferon-γ (IFN-γ)

1994 • 156 citations

Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency.

1997 • 142 citations

Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice.

1995 • 139 citations

Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice

1999 • 138 citations

Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice

1996 • 132 citations

Temporal loss of the activated L-selectin-low phenotype for virus-specific CD8+ memory T cells.

1995 • 130 citations

Virus-specific CD8⁺T cell numbers are maintained during γ-herpesvirus reactivation in CD4-deficient mice

1998 • 105 citations

gamma Interferon production appears to predict time of recurrence of herpes labialis.

1983 • 99 citations

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.

1999 • 91 citations

Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium

1996 • 89 citations

Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells

1997 • 86 citations

Herpes Simplex Virus Protein Targets for CD4 and CD8 Lymphocyte Cytotoxicity in Cultured Epidermal Keratinocytes Treated with Interferon-γ

1996 • 86 citations

In vitro analysis of the epstein‐barr virus: Host balance in long‐term renal allograft recipients

1985 • 86 citations

Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype.

1994 • 86 citations

Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68

1997 • 83 citations

Administration of Neomycin Resistance Gene Marked EBV Specific Cytotoxic T Lymphocytes to Recipients of Mismatched-Related or Phenotypically Similar Unrelated Donor Marrow Grafts. St. Jude Children's Research Hospital, Memphis, Tennesse

1994 • 83 citations

Cytokine production in the immune response to murine gammaherpesvirus 68

1996 • 75 citations

Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas.

1997 • 75 citations

The Role of CD4⁺ T Cells in Cell‐Mediated Immunity to LCM V: Studies in MHC Class I and Class II Deficient Mice

1994 • 71 citations

Herpesvirus Evasion of the Immune System

1998 • 68 citations

Epstein-Barr virus intrastrain recombination in oral hairy leukoplakia

1994 • 61 citations

Role of interferon-γ in immunity to herpes simplex virus

1996 • 59 citations

Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion.

1993 • 57 citations

Bacterial and protozoal infections in genetically disrupted mice

1994 • 54 citations

AIDS: Viruses, cytokines and Kaposi's sarcoma

1995 • 45 citations

Antiviral activity of NK 1.1+ natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus.

1994 • 33 citations

Cytotoxic T Cells and Human Herpes Virus Infections

1994 • 27 citations