Conversion of the active to latent plasminogen activator inhibitor from human endothelial cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

1966 • 2,239 citations

Plasminogen: Purification from Human Plasma by Affinity Chromatography

1970 • 2,160 citations

Starch-gel electrophoresis—Application to the classification of pituitary proteins and polypeptides

1964 • 964 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Evidence for a rapid inhibitor to tissue plasminogen activator in plasma

1983 • 479 citations

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

1984 • 455 citations

Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

1984 • 418 citations

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

1985 • 405 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

1986 • 386 citations

Demonstration of a fast-acting inhibitor of plasminogen activators in human plasma

1984 • 382 citations

Detection and partial characterization of an inhibitor of plasminogen activator in human platelets.

1984 • 365 citations

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

1984 • 345 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells.

1984 • 330 citations

Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

1986 • 310 citations

Protease nexin. Properties and a modified purification procedure.

1985 • 272 citations

Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex.

1983 • 250 citations

Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937.

1986 • 249 citations

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.

1986 • 232 citations

Secretion of tissue-type plasminogen activator and plasminogen activator inhibitor by cultured human endothelial cells: modulation by thrombin, endotoxin, and histamine.

1987 • 209 citations

The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related.

1985 • 171 citations

Reverse fibrin autography: A method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1984 • 170 citations

Isolation of tissue-type plasminogen activator-inhibitor complexes from human plasma

1984 • 132 citations

Inhibition of plasminogen activators by conditioned medium of human hepatocytes and hepatoma cell line Hep G2.

1985 • 132 citations

Quantitation and properties of the active and latent plasminogen activator inhibitors in cultures of human endothelial cells

1986 • 130 citations

Monoclonal Antibodies to Human 54,000 Molecular Weight Plasminogen Activator Inhibitor from Fibrosarcoma Cells - Inhibitor Neutralization and One-Step Affinity Purification

1986 • 120 citations

Human endothelial cells produce a plasminogen activator inhibitor and a tissue-type plasminogen activator-inhibitor complex

1984 • 118 citations

Production of a fibrinolytic inhibitor by cultured endothelial cells derived from human umbilical vein

1978 • 111 citations

Comparative studies of the fibrinolytic activity of cultured vascular cells

1979 • 101 citations

Inhibition of tissue-type plasminogen activator by conditioned medium from cultured human and porcine vascular endothelial cells

1983 • 99 citations

The dexamethasone-induced inhibitor of fibrinolytic activity in hepatoma cells. A cellular product which specifically inhibits plasminogen activation.

1982 • 95 citations

Endotoxin induction of an inhibitor of plasminogen activator in bovine pulmonary artery endothelial cells.

1986 • 85 citations

Platelet release protein which inhibits plasminogen activators.

1985 • 79 citations

Evidence for the presence of two different fibrinolytic inhibitors in human endothelial cell conditioned medium

1984 • 74 citations

Characterization of the dexamethasone-induced inhibitor of plasminogen activator in HTC hepatoma cells.

1986 • 72 citations

The Dexamethasone-Induced Inhibitor of Plasminogen Activator in Hepatoma Cells Is Antigenically-Related to an Inhibitor Produced by Bovine Aortic Endothelial Cells

1986 • 50 citations

Tissue plasminogen activator inhibitor in the epidermis

1985 • 11 citations