Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines.

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 487 citations

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

2001 • 438 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/peptide transporter PepT1

1999 • 182 citations

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

1993 • 157 citations

Down-regulation of Intrinsic P-glycoprotein Expression in Multicellular Prostate Tumor Spheroids by Reactive Oxygen Species

2001 • 109 citations

Glucose-Induced Hyperaccumulation of Cyclic AMP and Defective Glucose Repression in Yeast Strains with Reduced Activity of Cyclic AMP-Dependent Protein Kinase

1990 • 105 citations

Transporter-mediated Drug Interactions

2002 • 93 citations

Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein

2001 • 55 citations

Lack of modulation ofMDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant mcf-7 breast cancer cells

1999 • 18 citations

Influence of exogenous RARα gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines

1998 • 11 citations