Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma

Natural history of hepatocellular carcinoma and prognosis in relation to treatment study of 850 patients

1985 • 1,928 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1989 • 420 citations

Human soluble IL-6 receptor: its detection and enhanced release by HIV infection.

1992 • 342 citations

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.

1993 • 233 citations

Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures.

1990 • 226 citations

Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer

1991 • 214 citations

High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production.

1989 • 185 citations

Serum interleukin-6 level reflects the tumor proliferative activity in patients with colorectal carcinoma

1999 • 172 citations

Serum levels of interleukin 6 in patients with lung cancer

1995 • 169 citations

Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma.

1996 • 156 citations

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

1990 • 154 citations

Marked Elevation of Serum Interleukin-6 in Patients With Cholangiocarcinoma

1998 • 145 citations

Serum Interleukin-10 But Not Interleukin-6 Is Related to Clinical Outcome in Patients With Resectable Hepatocellular Carcinoma

2000 • 143 citations

Serum interleukin-6 levels reflect disease status of gastric cancer.

1996 • 137 citations

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver

1998 • 133 citations

Interleukin-6, Nitric Oxide, and the Clinical and Hemodynamic Alterations of Patients With Liver Cirrhosis

1999 • 116 citations

Interleukin-6 in Renal Cell Carcinoma

1992 • 114 citations

Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice.

1991 • 91 citations

Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus

1997 • 91 citations

Blocking signaling through the gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity

1999 • 80 citations

Circulating IL‐6 and sIL‐6R in Patients with Hepatocellular Carcinoma

2002 • 63 citations

Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death.

1996 • 62 citations

Serum levels of cytokines in hepatitis C-related liver disease: a longitudinal study.

1999 • 61 citations

Interleukin-6 Activity in Urine and Serum in Patients with Bladder Carcinoma

1992 • 52 citations

Circulating IL‐6‐type cytokines and sIL‐6R in patients with multiple myeloma

1999 • 50 citations

Elevated serum interleukin-6 levels in patients with acute hepatitis

1992 • 46 citations

Production of interleukin 6 from human liver cell lines: production of interleukin 6 is not concurrent with the production of alpha-fetoprotein.

1990 • 45 citations

The Influence of Interleukin-6 on the Growth of Human Esophageal Cancer Cell Lines

1996 • 42 citations

[Role of interleukin 6 in hepatocellular carcinoma].

1996 • 33 citations

Interleukin 6 production by peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection and primary biliary cirrhosis

1993 • 30 citations

Interleukin-6 production by human melanoma cell lines.

1992 • 22 citations

Downregulation of wild-type β-catenin expression by interleukin 6 in human hepatocarcinoma HepG2 cells: a possible role in the growth-regulatory effects of the cytokine?

2001 • 16 citations

Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides

2002 • 9 citations