CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection

2001 • 317 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

CD4+ T-cell subsets in autoimmunity

1997 • 249 citations

CD4+ regulatory T cells

2001 • 241 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

Selection and fine-tuning of the autoimmune T-cell repertoire

2002 • 149 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Critical Roles of Glycosaminoglycan Side Chains of Cartilage Proteoglycan (Aggrecan) in Antigen Recognition and Presentation

1998 • 97 citations

The induction of arthritis in mice by the cartilage proteoglycan aggrecan: Roles of CD4+ and CD8+ T cells

1992 • 91 citations

Proteoglycan‐induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice

1990 • 90 citations

CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis

1999 • 82 citations

Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage

1998 • 79 citations

Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis

1999 • 74 citations

Impaired Fas Signaling Pathway Is Involved in Defective T Cell Apoptosis in Autoimmune Murine Arthritis

2001 • 69 citations

A Genome Scan Using a Novel Genetic Cross Identifies New Susceptibility Loci and Traits in a Mouse Model of Rheumatoid Arthritis

2000 • 57 citations

A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice.

1995 • 55 citations

Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis

2000 • 54 citations

Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: Evidence of genetically acquired resistance to autoimmune disease

2001 • 44 citations

T and B Cell Recovery in Arthritis Adoptively Transferred to SCID Mice: Antigen-Specific Activation Is Required for Restoration of Autopathogenic CD4+ Th1 Cells in a Syngeneic System

2002 • 43 citations

Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan–induced murine arthritis

1994 • 42 citations

Mediators and Autopathogenic Effector Cells in Proteoglycan-Induced Arthritic and Clinically Asymptomatic BALB/c Mice

1994 • 29 citations

Affinity Purification of Antigen‐Specific Serum Immunoglobulin from the European Eel (Anguilla anguilla)

1992 • 25 citations

Adjuvant Composition Determines the Induction of Type II Collagen‐Induced Arthritis

1992 • 20 citations