Gene Transfer with Retrovirus Vectors

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

RNA tumor viruses

1982 • 833 citations

Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences

1981 • 657 citations

Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

1984 • 642 citations

Form and Function of Retroviral Proviruses

1982 • 627 citations

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

1982 • 624 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene

1980 • 556 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

1981 • 391 citations

Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion

1984 • 358 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

Hemopoietic stem cell differentiation

1980 • 333 citations

Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus

1983 • 289 citations

Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells

1984 • 258 citations

Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus

1981 • 254 citations

Germline integration of Moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death

1983 • 253 citations

Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus

1981 • 253 citations

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

1981 • 250 citations

DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning.

1981 • 231 citations

Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.

1984 • 229 citations

Transformation and replication in mouse cells of a bovine papillomavirus--pML2 plasmid vector that can be rescued in bacteria.

1982 • 226 citations

Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors.

1983 • 214 citations

Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells

1983 • 214 citations

Virus infection of murine teratocarcinoma stem cell lines

1977 • 212 citations

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT.

1983 • 208 citations

Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.

1983 • 193 citations

Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs

1983 • 191 citations

Expression of a Retrovirus Encoding Human HPRT in Mice

1984 • 182 citations

Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells.

1982 • 180 citations

Neoplastic differentiation: Interaction of simian virus 40 and polyoma virus with murine teratocarcinoma cells in vitro

1975 • 179 citations

Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.

1983 • 174 citations

Infectivity and methylation of retroviral genomes is correlated with expression in the animal

1981 • 165 citations

Intracisternal A-particle genes as movable elements in the mouse genome.

1983 • 162 citations

Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene.

1982 • 157 citations

Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.

1982 • 150 citations

Retroviruses and embryogenesis: Microinjection of Moloney leukemia virus into midgestation mouse embryos

1980 • 149 citations

DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells

1983 • 134 citations

Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection

1984 • 121 citations

Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vector

1984 • 121 citations

Amphotropic retrovirus vector system for human cell gene transfer.

1984 • 117 citations

Loss of intervening sequences in genomic mouse α-globin DNA inserted in an infectious retrovirus vector

1982 • 107 citations

Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences.

1984 • 106 citations

Infectious and Selectable Retrovirus Containing an Inducible Rat Growth Hormone Minigene

1984 • 99 citations

High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters

1984 • 96 citations

Eukaryotic viral vectors

1987 • 96 citations

Resistance of teratocarcinoma stem cells to infection with simian virus 40: Early events

1977 • 90 citations

Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus

1983 • 77 citations

Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events.

1983 • 61 citations

Lack of Multiplication of Ecotropic Murine C-Type Viruses in Mouse Teratocarcinoma Primitive Cells: Brief Communication2

1977 • 60 citations

Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus

1984 • 59 citations

Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells.

1982 • 58 citations

A bovine papilloma virus vector with a dominant resistance marker replicates extrachromosomally in mouse and E. coli cells.

1983 • 56 citations

Design of a Retrovirus-Derived Vector for Expression and Transduction of Exogenous Genes in Mammalian Cells

1983 • 56 citations

Expression of complete chicken thymidine kinase gene inserted in a retrovirus vector.

1984 • 51 citations

Plasmidial maintenance in rodent fibroblasts of a BPV1-pBR322 shuttle vector without immediately apparent oncogenic transformation of the recipient cells.

1984 • 49 citations

Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors.

1983 • 48 citations

Isolation of large T antigen-producing mouse cell lines capable of supporting replication of polyomavirus-plasmid recombinants.

1984 • 47 citations

The Nature of the Host Range Restriction of SV40 and Polyoma Viruses in Embryonal Carcinoma Cells

1982 • 23 citations

Vectors for introducing genes into cells of higher eukaryotes

1983 • 18 citations