Activation of a voltage-dependent chloride current in human neutrophils by phorbol 12-myristate 13-acetate and formyl-methionyl-leucyl-phenylalanine. The role of protein kinase C.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

Neutrophils and Host Defense

1988 • 375 citations

Separate Cl- conductances activated by cAMP and Ca2+ in Cl(-)-secreting epithelial cells.

1990 • 360 citations

Neutrophil kinetics and lung injury

1987 • 294 citations

Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.

1984 • 272 citations

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.

1984 • 262 citations

Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils.

1986 • 246 citations

Turning on the respiratory burst

1990 • 211 citations

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1991 • 192 citations

Ion transport, membrane potential, and cytoplasmic pH in lymphocytes: changes during activation

1989 • 187 citations

Activation of the PKC‐isotypes α, β₁, γ, δ, and ε by phorbol esters of different biological activities

1991 • 178 citations

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

1991 • 163 citations

Activation of the Neutrophil (Part 1 of 4)

1988 • 149 citations

Voltage-dependent kinetics of an anionic channel of large unit conductance in macrophages and myotube membranes

1984 • 133 citations

NAD(P)H oxidase activity in human neutrophils stimulated by phorbol myristate acetate.

1980 • 122 citations

Plasma membrane potential modulates chemotactic peptide-stimulated cytosolic free Ca2+ changes in human neutrophils.

1987 • 112 citations

Phospholipid-sensitive Ca2+-dependent protein kinase and its substrates in human neutrophils

1983 • 112 citations

Chloride conductance activated by external agonists and internal messengers in rat peritoneal mast cells.

1989 • 95 citations

Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion.

1980 • 91 citations

Voltage-dependent and Ca2(+)-activated ion channels in human neutrophils.

1990 • 88 citations

Chloride movements in human neutrophils. Diffusion, exchange, and active transport.

1986 • 83 citations

Inositol phosphate formation in fMet-Leu-Phe-stimulated human neutrophils does not require an increase in the cytosolic free Ca2+ concentration

1985 • 80 citations

Phorbol myristate acetate receptors in human polymorphonuclear neutrophils.

1985 • 75 citations

Regulation of CI− channels by multifunctional CaM kinase

1991 • 68 citations

A Voltage-Dependent Chloride Current Linked to the Cell Cycle in Ascidian Embryos

1990 • 60 citations

Recombinant human tumor necrosis factor alpha induces calcium oscillation and calcium-activated chloride current in human neutrophils. The role of calcium/calmodulin-dependent protein kinase.

1993 • 55 citations

Localized superoxide release by neutrophils can be provoked by a cytosolic calcium 'cloud'.

1991 • 47 citations

Receptors and Intracellular Signaling in Human Neutrophils

1990 • 44 citations

Protein kinase C isoforms in human neutrophil cytoplasts

1992 • 44 citations

Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein.

1987 • 42 citations

Protein Kinases in Neutrophils: A Review

1989 • 42 citations

Cytolytic T lymphocyte effector function requires plasma membrane chloride flux.

1986 • 34 citations

Phorbol ester-stimulated human neutrophil membrane depolarization is dependent on Ca2(+)-regulated Cl- efflux

1990 • 32 citations

Stearoyl-CoA desaturase gene expression in lymphocytes

1992 • 31 citations

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes.

1988 • 30 citations

Involvement of calcium in modulation of neutrophil function by phorbol esters that activate protein kinase C isotypes and related enzymes

1993 • 29 citations

Activation of permeabilized neutrophils: role of anions

1992 • 21 citations

Heterogeneity in the circulating neutrophil pool: studies on subpopulations separated by continuous flow electrophoresis

1992 • 20 citations

Ca2+-Dependent and Ca2+-independent mechanisms modulate whole-cell cationic currents in human neutrophils

1992 • 13 citations

Chemotactic Peptide Enhancement of Phorbol Ester-Induced Protein Kinase C Activity in Human Neutrophils

1990 • 10 citations

Activation of the human neutrophil respiratory burst by an anion channel blocker.

1988 • 5 citations