The biochemical characterization of detergent-solubilized insulin-like growth factor II receptors from rat placenta.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

1961 • 5,561 citations

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

1966 • 2,239 citations

Physical chemistry of macromolecules

1962 • 2,105 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

The size and detergent binding of membrane proteins.

1975 • 449 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Insulin‐Like Growth Factors I and II: Some Biological Actions and Receptor Binding Characteristics of Two Purified Constituents of Nonsuppressible Insulin‐Like Activity of Human Serum

1978 • 384 citations

Quantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes

1974 • 378 citations

Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication-stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor

1980 • 346 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

1976 • 319 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding.

1978 • 282 citations

Solubilization of bacterial membrane proteins using alkyl glucosides and dioctanoyl phosphatidylcholine

1975 • 267 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins

1980 • 250 citations

The Somatomedin C Binding Protein: Evidence for a Heterologous Subunit Structure*

1980 • 193 citations

Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling

1981 • 187 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

A unique proteolytic cleavage site on the beta subunit of the insulin receptor.

1981 • 167 citations

Purification and properties of the human placental insulin receptor.

1981 • 161 citations

Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

1976 • 161 citations

Characterization of the binding of multiplication-stimulating activity to a receptor for growth polypeptides in chick embryo fibroblasts.

1977 • 153 citations

Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling.

1982 • 140 citations

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.

1981 • 136 citations

Highly reactive impurities in Triton X-100 and Brij 35: Partial characterization and removal

1980 • 124 citations

Insulin receptor: Interaction with nonreceptor glycoprotein from liver cell membranes

1978 • 100 citations

Insulin-induced dissociation of its receptor into subunits: Possible molecular concomitant of negative cooperativity

1976 • 96 citations

Effect of alterations in the amphipathic microenvironment on the conformational stability of bovine opsin. 1. Mechanism of solubilization of disk membranes by the nonionic detergent, octyl glucoside

1978 • 88 citations

Isolation and Partial Sequence Analysis of Rat Basic Somatomedin*

1982 • 87 citations

Purified Human Somatomedin A and Rat Multiplication Stimulating Activity

1978 • 83 citations

A Preferential Binding Site for Insulin-Like Growth Factor II in Human andRat Placental Membranes*

1981 • 82 citations

Insulin binding to solubilized material from fat cell membranes: Evidence for two binding species

1978 • 75 citations

The crystal structure of 1-decyl .alpha.-D-glucopyranoside: a polar bilayer with a hydrocarbon subcell

1976 • 71 citations

Effects of octyl .beta.-glucoside on insulin binding to solubilized membrane receptors

1981 • 63 citations

Kinetics of progesterone binding to the chick oviduct receptor protein

1976 • 55 citations

Partial Purification, Characterization, and Assay of a Slightly Acidic Insulin-Like Peptide (ILAs) from Human Plasma*

1978 • 53 citations

Subunit structure of insulin receptor of rat adipocytes as demonstrated by photoaffinity labeling

1982 • 50 citations

Purification of a basic somatomedin, from human plasma Cohn fraction IV-1, with physicochemical and radioimmunoassay similarity to somatomedin-C and insulin-like growth factor

1979 • 45 citations

Physical properties of the detergent-extracted nerve growth factor receptor of sympathetic ganglia.

1979 • 40 citations

The Binding and Degradation of Insulin by Rat Liver Membranes: Demonstration of Three Distinct Insulin-Binding Components in Detergent-Solubilized Material from Liver Plasma Membrane*

1980 • 21 citations

Characterization of the human placental receptor for basic somatomedin

1982 • 18 citations

Insulin receptors in transformed fibroblasts and in adipocytes: a comparative study

1979 • 10 citations

An airfuge centrifugation procedure for the measurement of ligand binding to membrane-associated and detergent-solubilized plasma membrane receptors

1980 • 7 citations