Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1995 • 2,642 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Establishment of a human cell line (mono mac 6) with characteristics of mature monocytes

1988 • 565 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

Interleukin-10

1992 • 303 citations

Isolation of the Human Interleukin 10 Promoter. Characterization of the Promoter Activity in Burkitt's Lymphoma Cell Lines

1995 • 221 citations

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice.

1997 • 202 citations

Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.

1999 • 147 citations

Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1

1999 • 139 citations

Selective Regulation of Cytokine Induction by Adenoviral Gene Transfer of IκBα into Human Macrophages: Lipopolysaccharide-Induced, But Not Zymosan-Induced, Proinflammatory Cytokines Are Inhibited, But IL-10 Is Nuclear Factor-κB Independent

1999 • 122 citations

CD14 is expressed and functional in human B cells

1994 • 54 citations

IMPAIRED STAT3 ACTIVATION FOLLOWING LOCALIZED INFLAMMATORY STIMULUS IN IL-6-DEFICIENT MICE

1998 • 51 citations

Activation of the interleukin‐10 gene in the human T lymphoma line HuT 78: identification and characterization of NF‐κ B binding sites in the regulatory region of the interleukin‐10 gene

1997 • 49 citations

Identification and characterization of an essential, activating regulatory element of the human SIS/PDGFB promoter in human megakaryocytes.

1993 • 33 citations