Control of Plasmid Replication: Theoretical Considerations and Practical Solutions

On the Regulation of DNA Replication in Bacteria

1963 • 1,441 citations

Chromosome replication and the division cycle of Escherichia coli

1968 • 1,205 citations

Mini-F plasmid genes that couple host cell division to plasmid proliferation.

1983 • 544 citations

Translational control of IS10 transposition

1983 • 362 citations

Inhibition of ColE1 RNA primer formation by a plasmid-specified small RNA.

1981 • 362 citations

Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance

1980 • 335 citations

THE CONJUGATION SYSTEM OF F-LIKE PLASMIDS

1980 • 312 citations

Origin of replication of colicin E1 plasmid DNA.

1977 • 212 citations

Chromosome replication in Escherichia coli

1971 • 206 citations

Partitioning of plasmid R1 in Escherichia coli,

1980 • 195 citations

RNAs involved in copy-number control and incompatibility of plasmid R1.

1981 • 192 citations

Control of ColE1 DNA replication: the rop gene product negatively affects transcription from the replication primer promoter.

1982 • 189 citations

Mutations in R Factors ofEscherichia coliCausing an Increased Number of R-Factor Copies per Chromosome

1972 • 182 citations

On plasmid incompatibility

1978 • 181 citations

Autorepressor Model for Control of DNA Replication

1973 • 175 citations

Nucleotide sequence of the region of the origin of replication of the broad host range plasmid RK2

1981 • 174 citations

Plasmid incompatibility and control of replication: copy mutants of the R-factor R1 in Escherichia coli K-12

1975 • 168 citations

Replication of a bacterial episome under relaxed control

1969 • 168 citations

Molecular Biology, Pathogenicity, and Ecology of Bacterial Plasmids

1981 • 165 citations

Replication of a bacterial plasmid and an episome in Escherichia coli

1970 • 146 citations

A runaway-replication mutant of plasmid R1drd-19: Temperature-dependent loss of copy number control

1978 • 132 citations

Indices of Discriminability

1973 • 128 citations

Post-transcriptional control of expression of the repA gene of plasmid R1 mediated by a small RNA molecule.

1983 • 126 citations

Plasmid R6K DNA replication

1982 • 124 citations

Nucleotide sequence of the region of an origin of replication of the antibiotic resistance plasmid R6K.

1979 • 121 citations

Vegetative bacteriophage λ DNA

1967 • 110 citations

Round of Replication Mutant of a Drug Resistance Factor

1974 • 110 citations

Replication of R-factor R1 in Scherichia coli K-12 at different growth rates

1975 • 108 citations

Role of Nine Repeating Sequences of the Mini-F Genome for Expression of F-Specific Incompatibility Phenotype and Copy Number Control

1983 • 106 citations

A single base-pair alteration is responsible for the DNA overproduction phenotype of a plasmid copy-number mutant

1981 • 99 citations

Molecular genetics of broad host range plasmid RK2

1981 • 95 citations

Direct repeats of the F plasmid incC region express F incompatibility

1981 • 94 citations

Control of Plasmid R1 Replication: Functions Involved in Replication, Copy Number Control, Incompatibility, and Switch-off of Replication

1980 • 94 citations

Requirement of a plasmid-encoded protein for replication in vitro of plasmid R6K.

1978 • 94 citations

Relationship between chromosome replication and F′lac episome replication in Escherichia coli

1973 • 93 citations

Plasmid R6K DNA replication

1982 • 91 citations

The sites of action of the two copy number control functions of plasmid R1

1982 • 89 citations

Role of RNA transcripts in replication incompatibility and copy number control in antibiotic resistance plasmid derivatives

1981 • 88 citations

Isolation and characterization of the minimal fragment required for autonomous replication (“Basic replicon”) of a copy mutant (pKN102) of the antibiotic resistance factor R1

1978 • 87 citations

Bacterial Episomes and Plasmids.

1970 • 86 citations

Definition of oriR, the minimum DNA segment essential for initiation of R1 plasmid replication in vitro.

1983 • 78 citations

Replication of plasmid pT181 DNA in vitro: requirement for a plasmid-encoded product.

1981 • 69 citations

REGULATION OF INITIATION OF DNA REPLICATION

1979 • 68 citations

Isolation and characterization of new copy mutants of plasmid R1, and identification of a polypeptide involved in copy number control

1981 • 64 citations

Partitioning of plasmid R1 in Escherichia coli

1980 • 62 citations

Chromosome replication in Escherichia coli

1967 • 61 citations

Genetic structure and regulation of a replicon of plasmid λdv

1976 • 60 citations

Replication of antibiotic resistance plasmid R6K DNA in vitro

1978 • 59 citations

Replication control functions of plasmid R1 act as inhibitors of expression of a gene required for replication

1981 • 56 citations

Plasmid R1 DNA replication dependent on protein synthesis in cell-free extracts of E. coli

1981 • 53 citations

Replication control mutations of plasmid R6-5 and their effects on interactions of the RNA-I control element with its target

1983 • 53 citations

Selection and timing of replication of plasmids R1drd-19 and F′lac in Escherichia coli

1978 • 52 citations

Regulated expression of a gene important for replication of plasmid F in E. coli.

1984 • 51 citations

R6K Plasmid Replication: Influence of Chromosomal Genotype in Minicell-Producing Strains of Escherichia coli K-12

1974 • 51 citations

Release of initiation control by a mutational alteration in the R6K pi protein required for plasmid DNA replication.

1983 • 50 citations

Replication Control and Switch-Off Function as Observed with a Mini-F Factor Plasmid

1981 • 44 citations

Molecular cloning and functional characterization of a copy number control gene (copB) of plasmid R1

1982 • 42 citations

Suppression of an Escherichia coli dnaA mutation by the integrated R factor R100.1: origin of chromosome replication during exponential growth

1977 • 41 citations

The nucleotide sequence of the region surrounding the replication origin of an R100 resistance factor derivative

1979 • 41 citations

Initiation site of deoxyribonucleotide polymerization at the replication origin of the Escherichia coli chromosome

1983 • 40 citations

Conditional change of DNA replication control in an RNA polymerase mutant of Escherichia coli

1983 • 38 citations

Isolation and characterization of Escherichia coli chromosomal mutants affecting plasmid copy number

1976 • 38 citations

Synthesis and decay of λ DNA replication proteins in minicells

1980 • 38 citations

Control of Plasmid R1 Replication: Kinetics of Replication in Shifts Between Different Copy Number Levels

1980 • 37 citations

Purification of bacteriophage λO protein that specifically binds to the origin of replication

1981 • 33 citations

DNA Cloning and the Analysis of Plasmid Structure and Function

1978 • 31 citations

Intracellular pools of bacteriophage λ deoxyribonucleic acid

1970 • 30 citations

A novel type of E. coli mutants with increased chromosomal copy number

1983 • 29 citations

Role of an autorepression system in the control of λdv plasmid copy number and incompatibility

1980 • 28 citations

Kinetics of minichromosome replication in Escherichia coli B/r

1982 • 26 citations

Control of plasmid replication: A synthesis occasioned by the recent EMBO Workshop “replication of prokaryotic DNA,” held at de Eemhof, The Netherlands, May 1982 (organizers: Veltkamp and Weisbeek)

1983 • 26 citations

Gene dosage studies with pleiotropic mutants of Serratia marcescens superactive in the synthesis of marcescin A and certain other exocellular proteins

1973 • 26 citations

Replication properties of plasmid R6K

1981 • 25 citations

Evidence that F′ lac replicates asynchronously during the cell cycle of Escherichia coli B/r

1978 • 18 citations

Replication of plasmid R1: Meselson-Stahl density shift experiments revisited

1983 • 14 citations

Replication Signals in Prokaryotic DNA

1981 • 12 citations

Bacterial Episomes and Plasmids (a Ciba Foundation Symposium)

1970 • 7 citations

INTERACTION OF BACTERIOPHAGE LAMBDA O PROTEIN WITH THE LAMBDA ORIGIN SEQUENCE

1981 • 6 citations

Copy Number Control and Incompatibility of incFII R Plasmids

1981 • 6 citations