In vitro aging

Statistical methods

1967 • 19,533 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

Cellular senescence and DNA synthesis

1973 • 537 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

Altered Enzymes in Ageing Human Fibroblasts

1972 • 408 citations

VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS

1974 • 272 citations

The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro

1966 • 271 citations

DNA endoreduplication and polyteny understood as evolutionary strategies

1976 • 241 citations

ROLE OF CHROMOSOMES IN CANCEROGENESIS, AS STUDIED IN SERIAL TISSUE CULTURE OF MAMMALIAN CELLS

1958 • 220 citations

Intrinsic Mutagenesis: A Genetic Basis of Ageing

1974 • 180 citations

Ultrastructural changes accompanying the aging of human diploid cells in culture

1972 • 178 citations

ROLE OF CHROMOSOMES IN CANCEROGENESIS, AS STUDIED IN SERIAL TISSUE CULTURE OF MAMMALIAN CELLS

1958 • 176 citations

Viability of human diploid cells as a function ofin vitro age

1969 • 175 citations

Genealogies of clones of diploid fibroblasts

1974 • 165 citations

Proliferative capacity and DNA content of aging human diploid cells in culture: A cytophotometric and autoradiographic analysis

1974 • 141 citations

Increased nuclear sizes in senescent human diploid fibroblast cultures

1976 • 114 citations

The ageing, growth and death of cells

1974 • 105 citations

Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.

1975 • 96 citations

Early Chromosomal Changes in SV<sub>40</sub>-Infected Human Fibroblast Cultures

1964 • 95 citations

Aging in vitro

1974 • 89 citations

Altered rate of DNA replication in ageing human fibroblast cultures

1974 • 80 citations

Chromosome changes during the in vitro ageing of MRC-5 human fibroblasts

1975 • 77 citations

Cell Impairment in Aging and Development

1975 • 76 citations

Regulatory mechanism of cell division

1973 • 74 citations

Age-dependent excision repair of damaged thymine from γ-irradiated DNA by isolated nuclei from human fibroblasts

1975 • 72 citations

Chromosome methodologies in mutation testing

1972 • 68 citations

Endoreduplication in Human Fibroblast Cultures

1965 • 65 citations

Characterization of fractionated human diploid fibroblast cell populations

1976 • 54 citations

Chromatin template activity during aging in WI38 cells

1975 • 53 citations

Protein alterations in aging WI38 cells as determined by proteolytic susceptibility

1975 • 51 citations

Induction of endoreduplication in cultured mammalian cells by some chemical mutagens.

1974 • 49 citations

The Gardner syndrome: increased tetraploidy in cultured skin fibroblast.

1976 • 45 citations

Detection of mycoplasma in cell cultures

1975 • 44 citations

Possible mechanisms of endoreduplication induction

1975 • 41 citations

Increased degradation rates of protein in aging human fibroblasts and in cells treated with an amino acid analog

1976 • 35 citations

Polyploidy and endoreduplication in human leucocyte cultures treated with β-mercaptoethanol

1963 • 29 citations

Changes in Megakaryocyte Development Following Thrombocytopenia

1974 • 25 citations

Adaptation of mammalian cells to cold

1965 • 25 citations

Synthesis of DNA-binding protein in WI-38 cells stimulated to synthesize DNA by medium replacement

1974 • 24 citations

Spontaneous Chromosome Aberrations in Human Tissue Culture Cells

1961 • 21 citations

ENDOREDUPLICATION AND DISEASE

1965 • 19 citations

Endoreduplication in cultured mammalian cells treated with 4-nitroquinoline 1-oxide

1973 • 16 citations

A study of the cytogenetics of the human cell strain WI-38

1973 • 14 citations

Dose Rate, Mitotic Cycle Duration, and Sensitivity of Cell Transitions from G1 → S and G2 → M to Protracted Gamma Radiation in Root Meristems

1975 • 11 citations

Endoreduplication induced by hydroxylamine sulfate in Zea mays root tip nuclei

1974 • 9 citations

Concanavalin a induces endoreduplication in cultured mammalian cells

1975 • 4 citations