The whey acidic protein

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

The Mammary gland : development, regulation, and function

1987 • 396 citations

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion.

1985 • 279 citations

Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice

1987 • 273 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Complex hormonal regulation of rat casein gene expression.

1982 • 204 citations

Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis.

1991 • 196 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk

1987 • 194 citations

Mouse whey acidic protein is a novel member of the family of ‘four-disulfide core’ proteins

1982 • 193 citations

Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

1991 • 192 citations

High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice.

1990 • 179 citations

A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.

1988 • 177 citations

Comparison of the whey acidic protein genra of the rat and mouse

1984 • 176 citations

High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine.

1991 • 147 citations

Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.

1991 • 143 citations

Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases

1986 • 140 citations

A novel regulatory mechanism for whey acidic protein gene expression.

1989 • 137 citations

Molecular cloning and characterization of the Endo B cytokeratin expressed in preimplantation mouse embryos.

1986 • 136 citations

Characterization and Cloning of the mRNAs Specific for the Lactating Mouse Mammary Gland

1982 • 134 citations

Comparison of the Regulation of the Whey Acidic Protein Gene with that of a Hybrid Gene Containing the Whey Acidic Protein Gene Promoter in Transgenic Mice

1988 • 121 citations

A camel milk whey protein rich in half‐cystine

1986 • 110 citations

Bovine AlphaS1-Casein Gene Sequences Direct High Level Expression of Active Human Urokinase in Mouse Milk

1990 • 106 citations

Tissue-specific expression of the rat β-casein gene in transgenic mice

1988 • 102 citations

Efficient tissue‐specific expression of bovine α‐lactalbumin in transgenic mice

1989 • 96 citations

Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein

1982 • 91 citations

Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.

1988 • 87 citations

Tissue-specific, high level expression of the rat whey acidic protien gene in transgenic mice

1990 • 84 citations

Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level.

1988 • 83 citations

A Mammary-Specific Promoter Directs Expression of Growth Hormone not only to the Mammary Gland, but also to Bergman Glia Cells in Transgenic Mice

1991 • 82 citations

Molecular cloning of a cDNA sequence for rat malic enzyme. Direct evidence for induction in vivo of rat liver malic enzyme mRNA by thyroid hormone.

1983 • 79 citations

Complete sequence analysis of cDNA clones encoding rat whey phosphoprotein: homology to a protease inhibitor.

1982 • 74 citations

Nuclear proteins form lactating mammary glands bind to the promoter of a milk protein gene

1987 • 73 citations

Developmental regulation of mammary-derived growth inhibitor expression in bovine mammary tissue.

1990 • 72 citations

Recent data on the structure of rabbit milk protein genes and on the mechanism of the hormonal control of their expression

1988 • 68 citations

Biochemical characterization of a novel whey protein from murine milk.

1981 • 63 citations

Production of the mouse whey acidic protein in transgenic pigs during lactation

1991 • 54 citations

Expression of the whey acidic protein in transgenic pigs impairs mammary development

1992 • 53 citations

Breast Cancer Protein PS2 Synthesis in Mammary Gland of Transgenic Mice and Secretion into Milk

1989 • 52 citations

Rabbit Whey Acidic Protein Concentration in Milk, Serum, Mammary Gland Extract, and Culture Medium

1991 • 48 citations

Complementary DNA Cloning and Regulation of Expression of the Messenger RNA Encoding a Pregnancy-Associated Porcine Uterine Protein Related to Human Antileukoproteinase

1990 • 43 citations

Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids

1990 • 40 citations

Purification and Partial Characterization of a Unique Group of Phosphoproteins from Rat Milk Whey

1978 • 39 citations

Expression of human growth hormone in the milk of transgenic mice

1991 • 38 citations

Transgenic mice carrying the guinea-pig α-lactalbumin gene transcribe milk protein genes in their sebaceous glands during lactation

1991 • 36 citations

Sequence of the rabbit whey acidic protein cDNA

1988 • 35 citations

Functional human CD4 protein produced in milk of transgenic mice.

1989 • 31 citations

Complete sequence of the rabbit whey acidic protein gene

1990 • 25 citations

Low molecular weight serine proteinase inhibitors of human articular cartilage. Isolation, Characterization, and Biosynthesis

1990 • 16 citations

Antileukoprotease, its role in the human lung.

1988 • 10 citations

In vitro transcription of the mouse whey acidic protein promoter is affected by upstream sequences

1989 • 9 citations

Mammary gland whey acidic protein: ontogeny and changing patterns of steroid sensitivity

1989 • 4 citations